PHRM 623 Fundamentals of Pharmacology
FUNDAMENTALS OF PHARMACOLOGY 623 (II)
Spring 2007
Time: Monday, Tuesday, Wednesday, and Thursday, 4:00–5:00 P.M.
Location: Pharmacology Seminar Room, M100 John Morgan
Course Director: Jeffrey Field (8-1912; field@pharm.med.upenn.edu)
Starting Date: January 8, 2007
Day Date Lecture Lecturer
Pharmacokinetics and Drug Metabolism
Mon 1/8 The Drug Development Pipeline Molinoff
Tue 1/9 Pharmacokinetics/ Absorption Robinson
Wed 1/10 Pharmacokinetics/Distribution "
Thu 1/11 Pharmacokinetics/Metabolism "
Mon 1/15 No class (MLK Day)
Tue 1/16 Pharmacokinetics problem set due Robinson
Wed 1/17 Emerging Methods of Drug Delivery Muzykantov
Thu 1/18 Phase I Metabolism: Cytochrome P450s Song
Mon 1/22 Phase I Metabolism "
Tues 1/23 Phase II Metabolism "
Wed 1/24 Phase II Metabolism "
Thu 1/25 Metabolism problem set due "
Mon 1/29 Review (Robinson, Song)
Tues 1/30 Exam I
Principles of Toxicology
Wed 1/31 Principles of Toxicology Penning
Thurs 2/1 Biotransformation of Xenobiotics "
Mon 2/5 Biotransformation of Xenobiotics "
Tues 2/6 Nucleic Acid-Based Mechanisms Penning
Wed 2/7 Toxicology Problem set Due Penning
Thurs 2/8 Neurodegenerative Disease Giasson
Mon 2/12 No class
Tues 2/13 Redox Chemistry Ischiropoulos
Wed 2/14 Redox Chemistry in Toxiciology "
Thu 2/16 Review (Penning, others)
Mon 2/19 No class (Presidents' Day)
Tue 2/20 Exam 2
Rational Drug design
Wed 2/21 Molecular Shape and Symmetry Kung
Thu 2/22 Molecular Structure Determination van Duyne
Mon 2/26 Molecular Forces Axelsen
Tue 2/27 Molecular Thermodynamics "
Wed 2/28 Molecular Graphics "
Thu 3/1 Molecular Simulation "
Mon 3/5 SPRING BREAK
Tue 3/6 SPRING BREAK
Wed 3/7 SPRING BREAK
Thu 3/8 SPRING BREAK
Mon 3/12 Docking and Scoring Mohan
Tue 3/13 Quantitative Structure Activity Relationships "
Wed 3/14 No class Axelsen
Thu 3/15 No class "
Fri 3/16 Review (Axelsen, Kung) "
Mon 3/19 Exam 3
Systems Pharmacology
Tue 3/20 System Biology Overview Blair
Wed 3/21 Statistics 1 Troxel
Thu 3/22 Statistics 2 Troxel
Fri 3/23 Computer Tutorial Axelsen
Mon 3/26 Bioinformatics Pizarro
Tue 3/27 Proteomics and Lipidomics Methodology Blair
Wed 3/28 Proteomics and Lipidomics of Cancer Blair
Thu 3/29 Proteomics of Cardiovascular Disease Grosser
Mon 4/2 Proteomics of Neurodegenerative Disease Giasson
Tue 4/3 Proteomics/metabonomics problem set due Blair
Wed 4/4 Genomics I Eberwine
Thu 4/5 Genomics II Eberwine
Mon 4/9 Genomics III Hogenesch
Tue 4/10 Genomics problems/Review Eberwine/Hogenesch
Wed 4/11 Pharmacogenetics I Whitehead
Thu 4/12 Pharmacogenetics II "
Mon 4/16 Pharmacogenetics III "
Tue 4/17 Pharmacogenetics IV "
Wed 4/18 Pharmacogenomics problem set due
Thu 4/19 Review proteo/Pharmacogen Whitehead/Blair
Mon 4/23 Exam 4
Directory of Lecturers
Name Dept Phone Email
Dr. Paul Axelsen Pharmacology 898-9238 Axe@pharm.med.upenn.edu
Dr. Ian Blair Pharmacology 573-9885 ian@spirit.gcrc.upenn.edu
Dr. Jim Eberwine Pharmacology 898-5437 eberwine@pharm.med.upenn.edu
Dr. Jeffrey Field Pharmacology 898-1912 Field@pharm.med.upenn.edu
Dr. Tilo Grosser Pharm/ITMAT 573-7600 tilo@spirit.gcrc.upenn.edu
Dr. Benoit Giasson Pharmacology 573-6012 giassonb@mail.med.upenn.edu
Dr. John Hogenesch Pharmacology 573-1154 hogenesc@mail.med.upenn.edu
Dr. Harry Ischiropoulos Pediatrics 590-5320 ischirop@mail.med.upenn.edu
Dr. Hank Kung Radiology 662-3096 kunghf@sunmac.spect.upenn.edu
Dr. Venkatraman Mohan Sceata Technology 609 897 7960 vmohan@comcast.net
Dr. Perry Molinoff Pharmacology molinoff@pobox.upenn.edu
Dr. Vladimir Muzykantov Pharmacology 898-9823 muzykant@mail.med.upenn.edu
Dr. Trevor Penning Pharmacology 898-9445 Penning@pharm.med.upenn.edu
Angel Pizarro Pharm/ITMAT 573-3736 angel@mail.med.upenn.edu
Dr. Michael Robinson Pharmacology 590-2205 robinson@pharm.med.upenn.edu
Dr. Greg van Duyne Biochem & Biophysics 898-3058 vanduyne@mail.med.upenn.edu
Dr. Wenchao Song Pharmacology 573-6641 Song@spirit.gcrc.upenn.edu
Dr. Andrea B. Troxel Biostatistics 573-0659 atroxel@mail.med.upenn.edu
Dr. Steven Whitehead Pharmacology 898-2332 aswhitehead@pharm.med.upenn.edu