PHRM 623 Fundamentals of Pharmacology II
FUNDAMENTALS OF PHARMACOLOGY 623 (II)
2008
Time: Monday, Tuesday, Wednesday, and Thursday, 4:00–5:00 P.M.
Location: Pharmacology Seminar Room, M100 John Morgan
Course Director: David Manning (8-1775; manning@pharm.med.upenn.edu)
Blackboard site: https://courseweb.library.upenn.edu/
Starting Date: January 16, 2008
Day Date Lecture Lecturer
Wed 1/16 Pharmacokinetic Models: Drug Absorption Robinson
Thu 1/17 Pharmacokinetic Models: Drug Distribution "
Mon 1/21 No class (MLK Day)
Tue 1/22 Pharmacokinetic Models: Drug Elimination "
Wed 1/23 Emerging Methods of Drug Delivery Muzykantov
Thu 1/24 Pharmacokinetics problem set due Robinson
Mon 1/28 Phase I Metabolism: Cytochrome P450s Song
Tue 1/29 Phase I Metabolism "
Wed 1/30 Phase II Metabolism "
Thu 1/31 Phase II Metabolism "
Mon 2/4 Metabolism problem set due "
Tue 2/5 Review Robinson/Song
Wed 2/6 Principles of Toxicology Penning
Thu 2/7 Exam I
Mon 2/11 Redox Chemistry Ischiropoulos
Tue 2/12 Reox Chemistry in Toxicology "
Wed 2/13 Biotransformation of Xenobiotics Penning
Thu 2/14 Biotransformation of Xenobiotics "
Mon 2/18 Chemical carcinogenesis: DNA-adduct based Penning
mechanisms
Tue 2/19 Chemical Carcinogenesis: Non-DNA adduct "
based mechanisms
Wed 2/20 Neurodegenerative Disease Giasson
Thu 2/21 No Class
Mon 2/25 Toxicology Problem set Due Penning
Tue 2/26 Review Penning/others
Wed 2/27 No class
Thu 2/28 Exam 2
Mon 3/3 Molecular Forces Sharp
Tue 3/4 Molecular Thermodynamics "
Wed 3/5 Molecular Graphics "
Thu 3/6 Molecular Simulation "
Mon 3/10 SPRING BREAK
Tue 3/11 SPRING BREAK
Wed 3/12 SPRING BREAK
Thu 3/13 SPRING BREAK
Mon 3/17 Molecular Shape and Symmetry Kung
Tue 3/18 Molecular Structure Determination van Duyne
Wed 3/19 Docking and Scoring Mohan
Thu 3/20 Quantitative Structure Activity Relationships "
Mon 3/24 Review Sharp/Kung
Tue 3/25 No Class
Wed 3/26 Exam 3
Thu 3/27 System Biology Overview Blair
Mon 3/31 Proteomics and Lipidomics Methodology Blair
Tue 4/1 Bioinformatics Pizarro
Wed 4/2 Proteomics and Lipidomics of Cancer Blair
Thu 4/3 No Class
Mon 4/7 Proteomics of Neurodegenerative Disease Giasson
Tue 4/8 Genomics I Eberwine
Wed 4/9 Proteomics/metabolomics problem set due Blair
Thu 4/10 Genomics II Eberwine
Mon 4/14 Genomics III Hogenesch
Tue 4/15 Genomics Problem Set Due Eberwine/
Hogenesch
Wed 4/16 Pharmacogenetics I Whitehead
Thu 4/17 Pharmacogenetics II Whitehead
Mon 4/21 Pharmacogenetics III Whitehead
Tue 4/22 Pharmacogenetics IV Whitehead
Wed 4/23* Pharmacogenetics Problem Set Due Whitehead
Drug Development Pipeline Molinoff
Thu 4/24 Review of proteomics/pharmacogenetics Blair
Whitehead
Mon 4/28 Statistics I Troxel
Tue 4/29 Statistics II Troxel
Wed 4/30 Statistics III Troxel
Thu 5/1 No Class
Mon 5/5 Exam 4
*Class meets from 4-6 pm.
Directory of Lecturers:
Name Dept Phone Email
Ian Blair Pharmacology 573-9885 ian@spirit.gcrc.upenn.edu
Greg van Duyne Biochem & Biophysics 898-3058 vanduyne@mail.med.upenn.edu
Jim Eberwine Pharmacology 898-5437 eberwine@pharm.med.upenn.edu
Benoit Giasson Pharmacology 573-6012 giassonb@mail.med.upenn.edu
John Hogenesch Pharmacology 573-1154 hogenesc@mail.med.upenn.edu
Harry Ischiropoulos Pediatrics 590-5320 ischirop@mail.med.upenn.edu
Hank Kung Radiology 662-3096 kunghf@sunmac.spect.upenn.edu
Venkatraman Mohan Honeywell, Burdick 231-725-6281 venkatraman.mohan@Honeywell.com
and Jackson
Perry Molinoff Pharmacology 898-2832 molinoff@pobox.upenn.edu
Vladimir Muzykantov Pharmacology 898-9823 muzykant@mail.med.upenn.edu
Trevor Penning Pharmacology 898-9445 penning@pharm.med.upenn.edu
Angel Pizarro Pharm/ITMAT 573-3736 angel@mail.med.upenn.edu
Michael Robinson Pharmacology 590-2205 robinson@pharm.med.upenn.edu
Kim Sharp Biochem & Biophysics 573-3506 sharpk@mail.med.upenn.edu
Wenchao Song Pharmacology 573-6641 song@spirit.gcrc.upenn.edu
Andrea Troxel Biostatistics 573-0659 atroxel@mail.med.upenn.edu
Steven Whitehead Pharmacology 898-2332 aswhitehead@pharm.med.upenn.edu