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BMB 508 Principles and Applications of Biophysics and Biochemistry

Course Directors: G. (Van Duyne & J. Wand)

Source Texts:
VH: Principles of physical biochemistry (2nd edition), van Holde, Johnson & Ho, PrenticE Hall – Useful foundation
B&T: Introduction to proteins structure (2nd edition), Branden & Tooze, Garland Publishing

Lectures: Monday & Wednesday, 1:30 pm to 3:00 pm ~ 255 Anatomy-Chemistry

1. Introduction W Sept 5 Wand/Sharp VH Ch 2; Structure independent
2. Interactions M Sept 10 Sharp VH Ch 3.1-3.3; physics
3. Interactions W Sept 12 Sharp interactions; thermo; stat mech
4. Ligand Binding M Sept 17 Sharp ligand binding; eq. folding; VH Ch 14
5. Denaturation, Folding W Sept 19 Sharp Santoro-Bolen
6. Calorimetry M Sept 24 Liebman VH Ch. 2.5
7. Sedimentation W Sept 26 Englander VH Ch 5.3
8. NMR Spectroscopy M Oct 1 Wand VH Ch 12 (limited)
9. NMR Spectroscopy W Oct 3 Wand
10. NMR Spectroscopy M Oct 8 Wand
11. Spectroscopy – EPR W Oct 10 Tommos
12. Spectroscopic probes M Oct 15 Vanderkooi VH Ch 7-10;Structural info. only
13. Spectroscopic probes W Oct 17 Vanderkooi VH 9
14. Mid-Term Examination M Oct 22
15. Imaging – Optical W Oct 24 Vinogradov
16. Imaging – MRI M Oct 29 Borthakur
17. Crystallography W Oct 31 Ferguson VH Ch 6; Incl. adv. protein structure
18. Crystallography M Nov 5 Ferguson B&T
19. Molecular analysis – modeling W Nov 7 Dunbrack
20. Adv. Protein Structure M Nov 12 Van Duyne
21. Adv. Nucleic Acids Structure W Nov 14 Van Duyne
22. Adv. Nucleic Acids Structure M Nov 19 Van Duyne
23. High order structure (incl. EM) M Nov 26 Weisel
24. Scattering methods W Nov 28 Dominguez
25. Protein chemistry M Dec 3 DeGrado
26. Protein design & engineering W Dec 5 DeGrado design principles
27. Protein design & engineering M Dec 10 DeGrado mutagenesis; dbl. mutant cycles
28. Final Examination W Dec 12