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BMB 618 Application of High Resolution NMR Spectroscopy to Problems in Structural Biology

SAMPLE COURSE SCHEDULE

Tuesdays, 1 – 2:30;  Thursdays, 2 – 3:30
255 Anatomy-Chemistry Building

Professor A. Joshua Wand
E-mail:                                                        wand@mail.med.upenn.edu
Telephone:                                                  573-7288

Lecture Topics

 Lecture   Topics

1  Introduction/Basic Concepts

2  Product Operators

3  Superoperators

4  nD NMR

5  Technical Details

6  Technical Details

7  Proteins

8  1H 2D & 3D Library

9  Sequential & MCD Assignment

10 Polarization Transfer/X-resolved

11 Triple resonance

12 Large protein strategies

13 Structure determination

14 Dynamics

Prerequisites: Rudimentary knowledge of NMR and protein structure; Basic matrix algebra and calculus and elementary quantum mechanics

Recommended Text:

J. Cavanagh, W. J. Fairbrother, A. G. Palmer, III, N. Skelton “Protein NMR Spectroscopy”, Academic Press, New York, 1996 ISBN: 0121644901 (more formal/technical)

or

M. Levitt, “Spin Dynamics: Basics of Nuclear Magnetic Resonance”, John Wiley & Sons, 2001 ISBN: 047148922