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CAMB 532 Human Physiology

         This course will present a survey of the physiology of most of the major organ systems. It will integrate knowledge of cellular and molecular mechanisms into an understanding of function at the tissue, organ and organism levels. It will begin with a brief review of membrane physiology, followed by electrophysiology and signaling in nerve. Then, after a brief outline of neural control systems and their role in homeostasis, it will present motility and muscle, the cardiovascular system, respiration, the renal system, selected topics from the endocrine system and the gastrointestinal system. As well as providing a basis of integrative physiology for students in fields such as bioengineering and pharmacology, it should be of interest to students of cellular and molecular biology and genetic engineering who will need to appreciate the roles of specific systems and molecules at higher levels of organization.

Required text:               Medical Physiology, updated edition, Walter F.
Boron and Emile L. Boulpaep, Elsevier-Saunders,
2005.

Format:                        Three 1.5 hour lectures per week.

Evaluation:                    Three non-cumulative multiple-choice exams,
                                    each covering about one third of the course.

Prerequisites:    Although not a formal prerequisite, a good foundation in cell biology at the level of BIOM 600 (or an equivalent upper level undergraduate course) is strongly recommended. A general understanding of the chemistry and biochemistry of macromolecules, and of basic molecular biology will also be assumed.

Fall 2007         Mon, Weds, Fri,  9:00-10:30am

Directors: Dr Martin Pring and Kevin Foskett

Sept 7

BRB 1412

Dr. Pring

Orientation

Membrane Electrophysiology & Nerve

Sept 10

BRB 253

Dr. Hoshi

Action Potentials

Sept 12

BRB 253

Dr. Hoshi

Voltage-gated Ion Channels

Sept 14

BRB 253

Dr. Hoshi

Synaptic Transmission and Ligand-gated Ion Channels

Sept 17

BRB 253

Dr. Thomas

Autonomic Nervous System

Muscle

Sept 19

BRB 253

Dr. Baylor

Skeletal Muscle Signaling

Sept 21

BRB 1412

Dr. Baylor

Cardiac Signaling

Sept 24

BRB 253

Dr. Ostap

Contractile Proteins

Sept 26

BRB 253

Dr. Ostap

Muscle Contraction

Sept 28

No Class

Oct 1

TBA

Mid-term 1

Cardiovascular System

Oct 3

BRB 253

Dr. Sweeney

Smooth Muscle

Oct 5

BRB 1412

Dr. Goldman

Organization; Arteries & Veins; the Microcirculation

Oct 8

BRB 253

Dr. Goldman

Electrophysiology and the EKG; the Heart as a Pump

Oct 10

BRB 1412

Dr. Goldman

Regulation of Arterial Pressure and Cardiac Output

Oct 12

BRB 253

Dr. Goldman

Special Circulations; Integrated Control

Respiration

Oct 15

BRB 253

Dr Grippi

Functional Anatomy and Respiratory Mechanics

Oct 17

BRB 253

Dr Grippi

Ventilation, Perfusion, and Gas Exchange

Oct 19

BRB 253

Dr Grippi

Oxygen and Carbon Dioxide Transport

Oct 22

BRB 253

Dr Grippi

Control of Respiration

Renal System

Oct 24

BRB 253

Dr. Civan

Introduction & Glomerular Filtration

Oct 26

BRB 253

Dr. Civan

Clearance, Blood Flow & K+ Regulation

Oct 29

BRB 253

Dr. Civan

Regulation of Na+ Excretion

Oct 31

BRB 253

Dr. Civan

Regulation of Acid Excretion

Nov 2

BRB 253

Dr. Civan

Regulation of Water Excretion

Nov 5

No Class

Nov 7

BRB 253

Mid-term 2

 

Nov 9

BRB 253

Dr Birnbaum

Organization of Endocrine Control

Nov 12

BRB 253

Dr Birnbaum

Endocrine Control of Growth

Nov 14

BRB 253

Dr Birnbaum

Thyroid and Adrenal Glands

Nov 16

BRB 253

Dr Birnbaum

Endocrine Control of Metabolism

Integration

Nov 19

BRB 253

Dr. Khurana

Physiological Responses to Exercise

Nov 21

No Class

Nov 23

Thanksgiving

Nov 26

BRB 253

Dr. Khurana

Response to Altitude and Temperature

Gastrointestinal System

Nov 28

BRB 253

Dr. Foskett

Organization of the System

Nov 30

BRB 253

Dr. Foskett

Mouth to Stomach

Dec 3

BRB 253

Dr. Foskett

Gastric Function

Dec 5

BRB 253

Dr. Foskett

Pancreas and Hepatobiliary System

Dec 7

BRB 253

Dr. Foskett

Intestinal Functions

Dec 10

No Class

Dec 12

No Class

Dec 14

BRB 253

Final

Human Physiology CAMB 532 Faculty

"J Kevin Foskett" <foskett@mail.med.upenn.edu>, "Martin Pring" <pringm@mail.med.upenn.edu>, "Toshinori Hoshi" <hoshi@mail.med.upenn.edu>, "Steven Thomas" <thomas@pharm.med.upenn.edu>, "Stephen Murray Baylor" <baylor@mail.med.upenn.edu>, "Michael Ostap" <ostap@mail.med.upenn.edu>, “H Lee Sweeney” <lsweeney@mail.med.upenn.edu>, "Yale E Goldman" <goldmany@mail.med.upenn.edu>, "Grippi, Michael" <Michael.Grippi@va.gov>, "Mortimer M Civan" <civan@mail.med.upenn.edu>, "Morris J Birnbaum" <birnbaum@mail.med.upenn.edu>, "Tejvir S Khurana" <tsk@mail.med.upenn.edu >

J Kevin Foskett

898-1354

foskett@mail.med.upenn.edu

Martin Pring

898-6870

pringm@mail.med.upenn.edu

Toshinori Hoshi

573-7305

hoshi@mail.med.upenn.edu

Steven Thomas

573-4950

thomas@pharm.med.upenn.edu

Stephen Baylor

898-5559

baylor@mail.med.upenn.edu

Michael Ostap

573-9758

ostap@mail.med.upenn.edu

H Lee Sweeney

898-8727

lsweeney@mail.med.upenn.edu

Yale E Goldman

898-4017

goldmany@mail.med.upenn.edu

Michael Grippi

215-823-4576

Michael.Grippi@va.gov

Mortimer M Civan

898-8773

civan@mail.med.upenn.edu

Morris J Birnbaum

898-5001

birnbaum@mail.med.upenn.edu

Tejvir S Khurana

573-2640

tsk@mail.med.upenn.edu