BIOM 600
Cell Biology and Biochemistry
Fall 2005
Director: Michael Ostap (573-9758)
Office: B40 Anatomy Chemistry
Co-directors:
Theme I: Mark Lemmon (898-3072)/Mickey Marks (898-3204)
Theme II: Kevin Foskett (898-1354)
Theme III: Michael Ostap (573-9758)
Theme IV: Morrie Birnbaum (898-5001)
Lectures ~ MWF 10:30-12:00 ~ Austrian Auditorium
Textbook : “Molecular Biology of the Cell” Eds. Alberts, et al. 4 th ed. (2002)
| M, 9/12 | Intro to Class; Purification, analysis, and manipulation of biomolecules | M. Ostap |
| W, 9/14 | Themes in Compartmentation/Structure of Membranes | M. Marks/M. Lemmon |
| F, 9/16 | Immunological Techniques | M. Marks |
| THEME I | CELL COMPARTMENTATION | |
| M, 9/19 | Cellular Quality Control | M. Marks |
| W, 9/21 | Mitochondria | A. Dancis |
| F, 9/23 | Protein Biogenesis | M. Lemmon |
| M, 9/26 | No Class - CAMB Retreat | |
| W, 9/28 | Protein Folding/ER Quality Control | R. Doms |
| F, 9/30 | Microscopy Techniques (Biochemistry quiz held after lecture at 12 noon; should take 20 minutes) | J. Murray |
| M, 10/3 | Basics of Vesicular Transport | M. Marks |
| W, 10/5 | Protein Sorting in the Vacuolar System | C. Burd |
| F, 10/7 | Protein Internalization and Degredation | C. Burd |
| M, 10/10 | Exocytosis and Regulated Secretion | M. Birnbaum |
| W, 10/12 | Nucleus | M. Matunis |
| F, 10/14 | EXAM # 1 - COVERS THEME I - 6PM-10PM IN DUNLOP AUDITORIUM | |
| M, 10/17 | Introduction to Kinetics | J. Jarrett |
| THEME II | MEMBRANES AND SOLUTE TRANSPORT | |
| W, 10/19 | Protein-Protein Interactions | M. Lemmon |
| F, 10/21 | Basics of Protein Structure and Folding | K. Sharp |
| M, 10/24 | Principles of Solute Transport | K. Foskett |
| W, 10/26 | Ion Channels #1 | T. Hoshi |
| F, 10/28 | Ion Channels #2 | T. Hoshi |
| M, 10/31 | Protein Interactions in Ion Channels | C. Deutsch |
| W, 11/2 | Integrated Functions of Ion Channels | K. Foskett |
| THEME III | CELL MOTILITY AND ADHESION | |
| F, 11/4 | Actin Cytoskeleton | M. Ostap |
| M, 11/7 | Actin-Based Motility | M. Ostap |
| W, 11/9 | Microtubules | E. Holzbaur |
| F, 11/11 | Microtubule Cytoskeleton | E. Holzbaur |
| M, 11/14 | Adhesion | D. Boettiger |
| W, 11/16 | Cell-extracellular Interactions | D. Boettiger |
| F, 11/18 | Mitosis and Cytokinesis | E. Bi |
| M, 11/21 | EXAM # 2 - COVERS THEMES II & III - 6PM-10PM IN DUNLOP AUDITORIUM | |
| THEME IV | SIGNAL TRANSDUCTION | |
| W, 11/23 | Introduction to Signal Transduction/Metabolism | M. Birnbaum/ M. Lemmon |
| F, 11/25 | Thanksgiving Break | |
| M, 11/28 | G-Proteins | D. Manning |
| W, 11/30 | Nuclear Receptor Signaling | M. Lazar |
| F, 12/2 | Phospholipases/Calcium Signaling | B. Wolf/ K. Foskett |
| M, 12/5 | Serine and Threonine Phosphorylation | F. Lee |
| W, 12/7 | Activation by Tyrosine Phosphorylation | B. Birnbaum |
| F, 12/9 | Cell Cycle | F. Luca |
| M, 12/12 | Apoptosis | X. Yang |
| W, 12/14 | Review Session with TAs (attendance optional) | |
| F, 12/16 | EXAM # 3 - COVERS THEME IV |