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GCB 531 Intro to Genome Science

GCB 531-001, Fall 2007 – Introduction to Genome Science

Course directors: Dr. Warren Ewens and Dr. John Hogenesch

Mondays and Wednesdays, 9-10:30 am, see below for lecture locations

This course serves as an introduction to the main laboratory and theoretical aspects of genomics and computational biology, and has been divided into several parts: genomes, informatics, genetics, systems biology approaches, DNA array technology, functional genomics, and proteomics.  In each of these sections we’ve sought to add an applications component which will help drive these themes home, and more importantly, help understand how these technologies can be applied to genome science. 

GCB531 Themes:

Lecture Schedule:

Date

Instructor

Topic

Location

10-Sep

Riethman

Chromosome structure

12-Sep

Riethman

Genome mapping and sequencing

1311 Blockley

17-Sep

Riethman

Vetebrate genome sequencing and assembly

B33 Anat-Chem

19-Sep

Ewens

General statistics

1311 Blockley

24-Sep

Riethman

Applications: TBA

251 BRB

26-Sep

Hannenhalli

Introduction to computer models and genomics

251 BRB

1-Oct

Hannenhalli

Computer models and genomics

B33 Anat-Chem

3-Oct

Spielman

Linkage analysis in humans / lod scores

251 BRB

8-Oct

Spielman

Linkage disequilibrium and haplotype blocks

251 BRB

10-Oct

Spielman

Complex genetic traits  and diseases

1311 Blockley

15-Oct

Fall break

17-Oct

Mid-term exam

251 BRB

22-Oct

Sniegowski

Molecular evolution I

B33 Anat-Chem

24-Oct

Sniegowski

Molecular evolution II

1311 Blockley

29-Oct

Eberwine

DNA Microarray Technology

B33 Anat-Chem

31-Oct

Ewens

Statistical analysis of microarrays

1311 Blockley

5-Nov

TBA

Applications: Cancer genomics

251 BRB

7-Nov

Kim

Computational analysis

1311 Blockley

12-Nov

Kim

Systems approaches in biology

251 BRB

14-Nov

Bucan

Functional genomics: forward genetic screens

251 BRB

19-Nov

Hogenesch

Functional genomics: reverse genetic screens

251 BRB

21-Nov

Hogenesch

Applications: Functional genomics of circadian rhythms

251 BRB

26-Nov

Speicher

Proteomics: Introduction

251 BRB

28-Nov

Greenbaum

Proteomics

251 BRB

3-Dec

Greenbaum

Proteomics Applications

251 BRB

5-Dec

Review

251 BRB