Biophysics of molecular recognition, seeking to understand how pharmacologically active molecules recognize their target sites of action, and how they accomplish their function after binding to their target site.
Tetraspanin protein structure and role in degenerative disease processes.
Photosynthetic and respiratory electron transport chains in bacteria: structure, function, regulation and biogenesis of cytochromes and cytochrome complexes
Methodology of scientific inquiry in biological research, theoretical foundations of biology, and applications of logical and probabilistic models in biology
Professor of Physiology
611B Clinical Research Building
tel: (215) 898-4017
fax: (215) 898-2653
Molecular mechanism of muscle contraction, mechanochemistry and structural biology
Investigating the enzymatic basis for diversity generation in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution
The Laboratory of Molecular Imaging is developing NMR and optical imaging probes for the detection and/or treatment of cancer and heart disease and for elucidating metabolism and physiology in animal models of human disease and in human subjects.
Laboratory of Molecular Imaging homepage
Research Professor of Pediatrics, Department of Pediatrics
510C Abramson Research Building
Investigation of the mechanism(s) regulating metabolic function in normal and diseased states.
Structure-function of aldo-keto reductases (genes and enzymes): roles in steroid hormone action and chemical carcinogenesis
Center of Excellence in Environmental Toxicology
Penning AKR Superfamily website
Computational biology; molecular origin of cancer, cancer therapeutics and drug delivery using theoretical and computational tools at the molecular and system level
Research Professor of Dermatology
240 Clinical Research Building
Understanding the structure, function and regulation of serine proteases from inflammatory cells. Establishing the mechanism protease inhibition by proteins of the serpin family.
Professor of Pediatrics
Research Institute, The Children's Hospital of Philadelphia
310 Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
Enzymology of blood coagulation: Molecular mechanisms underlying proteinase specificity, enzymic regulation and macromolecular function
MRI of tissue microstructure and function, mathematical modeling, image processing