SERGEI A. VINOGRADOV, Ph.D.
Professor of Biochemistry and Biophysics
1013 Stellar-Chance Bldg.
422 Curie Blvd.
Philadelphia, PA 19104
T: (215) 573-7524
F: (215) 573-3787
Ph.D. Moscow State University (1995) Organic Chemistry
DESCRIPTION OF RESEARCH INTERESTS:
Dr. Vinogradov's laboratory is focused on the development of advanced probes for microscopy and imaging applications. On the fundamental level our interests encompass chemistry of porphyrins and other pyrrolic dyes, energy and electron transfer in multichromophoric systems, spectroscopy and imaging. Essentially, we are a group of synthetic and physical chemists developing new techniques for biomedical research. Over the past years the main focus of the lab has been optical imaging of oxygen in biological systems, including chemistry of imaging probes, phosphorescence lifetime imaging instrumentation, image reconstruction methods and a variety of applications of phosphorescence. Other bio-analytes of interests have been pH and metal ions. Currently the laboratory currently pursues interests in optical energy upconversion and magnetic field effects on luminescence in view of their applications in imaging. Dr. Vinogradov collaborates broadly with laboratories across the world whose interests include basic studies of cellular metabolism and applications in neuroscience, stem cell biology, cancer therapy, tissue engineering and ophthalmology.