SERGEI A. VINOGRADOV, Ph.D.

Associate Professor of Biochemistry and Biophysics

1015 Stellar-Chance Bldg.
422 Curie Blvd.
Philadelphia, PA 19104
T: (215) 573-7524
F: (215) 573-3787
vinograd@mail.med.upenn.edu

Ph.D. Moscow State University (1995) Organic Chemistry

DESCRIPTION OF RESEARCH INTERESTS:

Dr. Vinogradov's research revolves around functional molecular systems related to biological objects by function or application. He uses methods of synthetic organic chemistry to design and construct molecules with predefined degree of active site encapsulation, photophysical properties and tunable energy and electron transfer pathways. The lab's special area of interest is construction of advanced probes for optical microscopy and imaging. They are developing methods for imaging of oxygen in biological tissues using phosphorescence quenching, including near infrared tomography by phosphorescence lifetime and two-photon microscopy of oxygen. These techniques are expected to provide useful tools for research in cancer, diabetes, ophthalmology and neuroscience. Two areas of chemistry are recurrent in their research: porphyrins and dendrimers. They study photophysics, acid/base properties and electrochemistry of aromatically π-extended porphyrins, addressing various structure-property relationships in this porphyrin family.