Hydrogen-Deuterium exchange Mass Spectrometry (HX-MS)

This methodology is useful for measuring protein backbone dynamics and structure in purified proteins and complexes. Solvent accessibility is reflected in the ability of hydrogens in the structure to exchange with deuterium in solvent, as measured by mass spectrometry.

  • LTQ-Orbitrap equipped with customized chromatography for HX on front end.

Prices for the Penn Community* (FY 2017):

Initial training: $150/day – mandatory for first three days of use
Instrument use: $50/day


This instrument is located within the department at 1007 Stellar-Chance Laboratory


Leland Mayne



1007 Stellar-Chance Laboratories

Prices for the Penn Community*:

Initial training: $150/day**

Instrument use: $50/day


Download a billing form:

.docx or .pdf


includes all schools of Penn as well as HUP, CHOP, and Wistar


mandatory for first three days of use