News & Publications
Bowman Lab in J Phys Chem B.
April 2024
G Protein Activation Occurs via a Largely Universal Mechanism
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Black Lab and Chang Lab in Nat Commun.
March 2024
Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling
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Black Lab in Science.
March 2024
Efficient formation of single-copy human artificial chromosomes
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Black Lab in Elife.
March 2024
Structural basis for the phase separation of the chromosome passenger complex
Read more.
Bernstein Lab in DNA Repair.
March 2024
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site
Read more.
Taabazuing Lab in Cells.
February 2024
Harnessing Pyroptosis for Cancer Immunotherapy
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Tolbert Lab in Sci Adv.
February 2024
Enterovirus evolution reveals the mechanism of an RNA-targeted antiviral and determinants of viral replication
Read more.
Bowman Lab in Protein Sci.
February 2024
Toward physics-based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants
Read more.
Burslem Lab in RSC Chem Biol.
February 2024
Sortase mediated protein ubiquitination with defined chain length and topology
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Shorter Lab in PLos Genet.
February 2024
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
Read more.
Bernstein Lab in DNA Repair
February 2024
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site
Read more.
Zhou Lab in J Am Chem Soc.
January 2024
Unusual Base Pair between Two 2‑Thiouridines and Its Implication for Nonenzymatic RNA Copying
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Bowman Lab in J Chem Theory Comput.
January 2024
PopShift: A Thermodynamically Sound Approach to Estimate Binding Free Energies by Accounting for Ligand-Induced Population Shifts from a Ligand-Free Markov State Model
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Kohli Lab in Elife.
January 2024
Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors
Read more.
Taabazuing Lab in Elife.
January 2024
Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS
Read more.
Chang Lab in Nat Commun.
January 2024
Sustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins
Read more.
Marmorstein Lab in J Struct Biol.
January 2024
Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation
Read more.
Murakami and Chang Labs in Curr Opin Struct Biol.
January 2024
Combining per-particle cryo-ET and cryo-EM single particle analysis to elucidate heterogeneous DNA-protein organization
Read more.
Tolbert Lab in Viruses.
December 2023
The Repurposing of Cellular Proteins during Enterovirus A71 Infection
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Taabazuing Lab in Cell Rep.
December 2023
The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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Moiseenkova-Bell Lab in Structure.
December 2023
Structural mechanism of TRPV5 inhibition by econazole
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Sgourakis Lab in Nat Commun.
December 2023
Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition
Read more.
Sgourakis Lab in Sci Immunol.
December 2023
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion
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Burslem Lab in Chem Commun.
November 2023
Lead-oriented synthesis of epigenetic relevant scaffolds
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Black Lab in Sci Adv.
November 2023
Centromere innovations within a mouse species
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Cherry Lab in Mol Cell.
November 2023
The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
Read more.
Timperman Lab in Lab Chip.
November 2023
Measuring the electrophoretic mobility and size of single particles using microfluidic transverse AC electrophoresis (TrACE)
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Burslem and Sellmyer Labs in Nat Commun.
November 2023
Regulation of eDHFR-tagged proteins with trimethoprim PROTACs
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Cherry Lab in Mol Cell.
November 2023
1The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
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Sellmyer Lab in Mol Ther.
November 2023
A genetically-encoded protein tag for control and quantitative imaging of CAR T cell therapy
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Sgourakis Lab in Nat Commun.
October 2023
HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes
Read more.
Rhoades & Petersson Labs in Biomolecules.
October 2023
The Effects of Lipids on α-Synuclein Aggregation In Vitro
Read more.
Moiseenkova-Bell Lab in Commun Biol.
September 2023
Intrinsically disordered regions in TRPV2 mediate protein-protein interactions
Read more.
Rhoades Lab in Mol Biol Cell.
September 2023
The C-terminus of α-Synuclein regulates its dynamic cellular internalization by Neurexin 1β
Read more.
Burslem and Vinogradov Labs in Int J Radiat Oncol Biol Phys.
September 2023
Direct Measurements of FLASH-Induced Changes in Intracellular Oxygenation
Read more.
Shorter Lab in Mol Cell.
August 2023
Tuning Hsp104 specificity to selectively detoxify α-synuclein
Read more.
Black Lab in Curr Biol.
August 2023
Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly
Read more.
Chang Lab in Nat Commun.
August 2023
Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography
Read more.
Sgourakis and Burslem Labs in J Biol Chem.
August 2023
A Chicken Tapasin ortholog can chaperone empty HLA-B*37:01 molecules independent of other peptide-loading components
Read more.
Kohli Lab in Nat Chem Biol.
June 2023
Direct enzymatic sequencing of 5-methylcytosine at single-base resolution
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Petersson Lab in J Am Chem Soc.
June 2023
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies
Read more.
Sgourakis and Burslem Labs in PNAS.
June 2023
Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes
Read more.
Yi-Wei Chang Selected as a Burroughs Wellcome Investigator in the Pathogenesis of Infectious Disease.
May 2023
Congratulations to Yi-Wei Chang for being named as a 2023 Burroughs Wellcome Investigator in the Pathogenesis of Infectious Disease!
Read more.
Nootan Pandey featured in Trends in Biochemical Sciences.
May 2023
Postdoc Nootan Pandey of the Black Lab has been highlighted by "Trends in Biochemical Sciences" for her abilities in scientific figure development.
Read more.
Marmorstein Lab in Nat Commun.
April 2023
Allosteric role of the citrate synthase homology domain of ATP citrate lyase
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Liu Lab in Genes Dev.
April 2023
Noncatalytic regulation of 18 S rRNA methyltransferase DIMT1 in acute myeloid leukemia
Read more.
Chang Lab in Proc Natl Acad Sci U S A.
April 2023
High-throughput cryo-ET structural pattern mining by unsupervised deep iterative subtomogram clustering
Read more.
Kohli & Petersson Labs in Protein Sci.
March 2023
FRETing About the Details: Case studies in the use of a genetically encoded fluorescent amino acid for distance-dependent energy transfer
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Chang Lab in J Mol Biol.
March 2023
Computational methods toward unbiased pattern mining and structure determination in cryo-electron tomography data
Read more.
Lynch Lab in Cell Rep.
March 2023
Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression
Read more.
Bowman Lab featured in Penn Medicine News.
March 2023
Recent work from the Bowman Lab has been featured by Penn Medicine News in their press release, "Penn Medicine Research Suggests More Cancers Can Be Treated with Drugs Than Previously Believed".
Read more.
Bowman Lab in Nat Commun.
March 2023
Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network
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Van Duyne/Gupta Lab in PLoS Pathog.
March 2023
Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization
Read more.
Burslem Lab in Front Physiol.
February 2023
Chemical probe mediated visualization of protein S-palmitoylation in patient tissue samples
Read more.
Cherry Lab in mBio.
February 2023
Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages
Read more.
Chang Lab in Methods Mol Biol.
February 2023
In Situ Structure Determination of Bacterial Surface Nanomachines Using Cryo-Electron Tomography
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Shorter Lab in J Biol Chem.
February 2023
A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
Read more.
Sgourakis and Burslem Labs in Sci Adv.
February 2023
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
Read more.
Kathy Liu Awarded 2023 Damon Runyon-Rachleff Innovation Award.
February 2023
Congratulations to Assistant Professor Kathy Fange Liu, PhD for receiving a 2023 Damon Runyon-Rachleff Innovation Award for her proposed research, "Y chromosome proteins in sex bias of cancers in non-reproductive organs."
Read more.
Murakami and Chang Labs in Mol Cell.
January 2023
Structural basis of a transcription pre-initiation complex on a divergent promoter
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Bowman Lab in Elife.
January 2023
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Read more.
Sgourakis Lab in Front. Immunol.
January 2023
Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules
Read more.
Marmorstein Lab in Structure.
December 2022
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase
Read more.
Vinogradov Lab featured in Penn Today & SPIE.
December 2022
Recent work from the Vinogradov Lab on oxygen consumption in the brain has been featured in articles published by Penn Today and SPIE.
Read more: Penn Today and SPIE.
Kohli Lab in ACS Chem Biol.
December 2022
Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A
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Rhoades Lab in J Biol Chem.
November 2022
The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches
Read more.
Vinogradov Lab in Neurophotonics.
November 2022
Real-time tracking of brain oxygen gradients and blood flow during functional activation
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Timperman Lab in Anal. Chem.
November 2022
Analyte Enrichment via Ion Concentration Polarization with Hydrogel Plugs Polymerized in PDMS Microchannels by a Facile and Comprehensive Method for Improved Polymerization
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Marmorstein Lab in J Biol Chem.
October 2022
The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity
Read more.
Lynch Lab in Elife.
October 2022
Alternative splicing of apoptosis genes promotes human T cell survival
Read more.
Natoya Peart in iScience.
October 2022
The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function
Read more.
Chang Lab in EMBO J.
October 2022
An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma
Read more.
Chang Lab in Microbiol Spectr.
October 2022
Bacterial Outer Membrane Polysaccharide Export (OPX) Proteins Occupy Three Structural Classes with Selective β-Barrel Porin Requirements for Polymer Secretion
Read more.
George Burslem Receives NIH Transformational Research Award.
October 2022
Department member George Burslem has been awarded an NIH Transformative Research Award, along with 7 other Penn scientists who received NIH grants. This award promotes cross-cutting, interdisciplinary science and is open to individuals and teams of investigators who propose research that could potentially create or challenge existing paradigms.
Read more.
Shorter Lab in Cell Reports.
September 2022
Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3
Read more.
Shorter Lab in JACS Au.
September 2022
Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses
Read more.
Bernstein Lab in PLoS Genet.
September 2022
Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer
Read more.
Liu Lab in Nat Commun.
September 2022
Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila
Read more.
Bernstein Lab in Mol. Cancer Ther.
September 2022
Targeting Therapeutic Resistance and Multinucleate Giant Cells in CCNE1-Amplified HR-Proficient Ovarian Cancer
Read more.
Vinogradov Lab in Inorg. Chem.
September 2022
Unusual Reactivity and Metal Affinity of Water-Soluble Dipyrrins
Read more.
Murakami and Moiseenkova-Bell Labs in J. Virol.
August 2022
Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP
Read more.
Black Lab in Sci Adv.
August 2022
Molecular basis of hUHRF1 allosteric activation for synergistic histone modification binding by PI5P
Read more.
Sellmyer Lab in CCR.
August 2022
Monitoring Therapeutic Response to Anti-Fibroblast Activation Protein (FAP) CAR T Cells using [18F]AlF-FAPI-74
Read more.
Congratulations Bowman Lab
August 2022
Congratulations to the Bowman Lab for being awarded an NSF grant.
Sellmyer Lab in AACR.
July 2022
Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation
Read more.
Marmorstein Lab in PNAS.
July 2022
Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity
Read more.
Congratulations Timothy Carter and Keegan Krick
July 2022
Congratulations to PhD candidates and department affiliates Timothy Carter and Keegan Krick on being appointed to the Genetics T32 training grant.
Vinogradov Lab in STAR Protocols.
June 2022
Measurement of Cerebral Oxygen Pressure in Living Mice by Two-Photon Phosphorescence Lifetime Microscopy
Read more.
Congratulations Jean Etersque
June 2022
Congratulations to PhD student, Jean Etersque, from the Sellmyer Lab on being awarded an F31 from the NIH.
Sgourakis and Burslem Labs in Nat Chem Biol.
June 2022
TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules
Read more.
Vinogradov Lab in Int J Radiat Oncol Biol Phys.
March 2022
Ultrafast Tracking of Oxygen Dynamics during Proton FLASH
Read more.
Dr. Chang named inaugural fellow by The EMBO Journal
March 2022
Congratulations Yi-Wei Chang, named international inaugural fellow with the Catalysts Program
Read more.
Martinez awarded inaugural fellowship
March 2022
Congratulations BMB student, Matthew Martinez, award inaugural Martin & Pamela Winter Infectious Disease Fellowship for early-career biomedical scientists
Read more.
Dr. Dreyfuss wins Lifetime Achievement Award
March 2022
Congratulations Gideon Dreyfuss for the 2022 Lifetime Achievement Award
Cherry Lab in Nature
February 2022
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
Read more.
Congratulations to Dr. Sara Cherry
January 2022
Dr. Cherry, secondary faculty in the Dept. of Biochemistry & Biophysics, was named to the 2021 Class of American Association for the Advancement of Science Fellows.
Murakami Lab in Molecular Cell
January 2022
Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II
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Cherry Lab in Cell Reports
December 2021
Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes
Read more.
Collaborative Paper from Black Lab in Nature Communications
November 2021
HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
Read more.
Black Lab in Cell Reports
November 2021
Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-A K124ub
Read more.
Marmorstein & Shorter Labs in Journal of Biological Chemistry
October 2021
N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate
Read more.
Brady, Marmorstein, & Burslem in Journal of Biological Chemistry
October 2021
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation
Read more.
Kohli Lab in Nature Chemical Biology
October 2021
Controllable genome editing with split-engineered base editors
Read more.
Kristen Lynch earns student mentoring award
October 2021
Congratulations to Dr. Lynch, recipient of the 2021 Michael P. Nusbaum Graduate Student Mentoring Award
Ben Black earn NIH Award
October 2021
Congratulations to Ben Black, PhD, recipient of the NIH Director's Transformative Research Award
Read more.
Petersson Lab in Chemical Science
August 2021
Genetic encoding of a highly photostable, long lifetime fluorescent amino acid for imaging in mammalian cells
Read more.
New Structural Biology Lab
October 2021
Vera Moiseenkova-Bell leads program providing accessible technology and intellectual support to the Penn community.
Read more.
Burslem Lab in RSC Medicinal Chemistry
August 2021
Photochemical synthesis of an epigenetic focused tetrahydroquinoline library. RSC Med Chem. 2021 Aug 25;12(10):1780-1786
Read more.
Liu Lab in Journal of Biological Chemistry
August 2021
Human DIMT1 generates N 26,6 A-dimethylation-containing small RNAs
Read more.
Shorter Lab in Journal of Molecular Biology
August 2021
Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease
Read more.
Moiseenkova-Bell Lab in Structure
August 2021
Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium
Read more.
Collaborative paper from Shorter and Marmorstein Labs in Nature
August 2021
DAXX represents a new type of protein-folding enabler
Read more.
Chang Lab in Nature Communications
August 2021
In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems
Read more.
Collaborative paper from Shorter Lab in Cell
August 2021
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
Read more.
Collaborative Paper from Moiseenkova-Bell Lab in Journal of Virology
August 2021
Context-Specific Function of the Engineered Peptide Domain of PHP.B
Read more.
Matt Gazzara awarded Blavatnik Family Fellowship
July 2021
Congratulations to Matt Gazzara, Barash and Lynch Lab member, recipient of a Blavatnik Family Fellowship in Biomedical Research
Read more.
Van Duyne Lab in Genome Biology
June 2021
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Read more.
Burslem Lab in Journal of Medicinal Chemistry
May 2021
Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres
Read more.
Sgourakis Lab in Nature Communications
May 2021
TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap
Read more.
Marmorstein & Peterson Labs in Structure
May 2021
Molecular mechanism of N-terminal acetylation by the ternary NatC complex
Read more.
Wilson and Matschinsky in Frontiers in Physiology
May 2021
Metabolic Homeostasis in Life as We Know It: Its Origin and Thermodynamic Basis
Read more.
Garcia Lab Collaborates on Paper in Molecular Cell
May 2021
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML
Read more.
Lynch, Cherry, and Barash Labs in PNAS
April 2021
Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia
Read more.
Murakami Lab in Science Advances
April 2021
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II
Read more.
Cherry Lab in Cell Reports
April 2021
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Read more.
Vinogradov Lab in Journal of Physical Chemistry A
April 2021
syn-Diarylphthalimidoporphyrins: Effects of Symmetry Breaking on Two-Photon Absorption and Linear Photophysical Properties
Read more.
Garcia Lab in Journal of Proteome Research
March 2021
Improved SILAC Quantification with Data-Independent Acquisition to Investigate Bortezomib-Induced Protein Degradation
Read more.
Heidi Elashal awarded NSF Fellowship
March 2021
Elashal, Liu Lab member and BMB Student, received NSF Grad Research Fellowship
Daniela Fera named a 2021 Cottrell Scholar
March 2021
Congratulations Daniela Fera, honored for making an impact on science, on students, and across academia.
Sharp Lab in Journal of Chemical Information and Modeling
March 2021
Computational Graphics Software for Interactive Docking and Visualization of Ligand-Protein Complementarity
Read more.
Burslem on ACS Chemical Biology Advisory Board
March 2021
Congratulations to George Burslem on being named a member of Early Career Advisory Board for ACS Chemical Biology
Daldal and Murakami Labs in Nature Communications
February 2021
Cryo-EM structures of engineered active bc 1-cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes
Read more.
Sgourakis Lab in Nature Communications
January 2021
Backbone-independent NMR resonance assignments of methyl probes in large proteins
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Sellmyer Lab in ACS Chemical Biology
January 2021
A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions.
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Gupta/Van Duyne Lab in Structure
December 2020
Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions.
Read more.
Vinogradov Lab in Journal of Physical Chemistry A
December 2020
Three-Photon Spectroscopy of Porphyrins
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Shorter Lab in Elife
December 2020
Therapeutic genetic variation revealed in diverse Hsp104 homologs
Read more.
Petersson & Rhoades Labs in Journal of the American Chemical Society
December 2020
Effects of Glutamate Arginylation on α-Synuclein: Studying an Unusual Post-Translational Modification through Semisynthesis
Read more.
Shorter Lab in Cell Reports
December 2020
TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease
Read more.
Lynch & Cherry Labs in Elife
December 2020
Viral-induced alternative splicing of host genes promotes influenza replication
Read more.
Petersson & Rhoades Labs in Chembiochem
December 2020
Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically-Labelled α-Synuclein with Site-specific Tyrosine Phosphorylation
Read more.
Kushol Gupta and the Johnson Foundation Biophysical and Structural Biology Core (JF-BSB) receive S10 Grant
November 2020
Congratulations Kushol Gupta and the Johnson Foundation Biophysical and Structural Biology Core (JF-BSB) for a successful S10 grant for a new multi-wavelength Beckman-Coulter Optima analytical ultracentrifuge (AUC). AUC has long been used to separate macromolecules in solution based on their hydrodynamic properties and to ascertain information about size and shape, accelerating study in all areas of basic biomedical research, from structural biology to the characterization of biologics and gene vectors. The Optima AUC will provide a state-of-the art advance in multi-wavelength technology, allowing investigators at Penn the ability to approach a range of questions not previously possible in complex systems, including mass and stoichiometry, shape, aggregation state and oligomerization, ligand binding, conjugation efficiency, and polydispersity. Importantly, this S10 award places Penn as one of the few academic centers providing core access to such instrumentation.
Cherry Lab in mBio
October 2020
DDX56 Binds to Chikungunya Virus RNA To Control Infection.
Read more.
Ben Black receives Penn Medicine Award
October 2020
Congratulations to Ben Black, PhD, recipient of Stanley Cohen Award for Excellence in Biomedical Research.
Read more.
Shorter Lab in Journal of American Chemical Society
September 2020
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers.
Read more.
Van Duyne Lab in Retrovirology
August 2020
Influence of the amino-terminal sequence on the structure and function of HIV integrate.
Read more.
Liu Lab in Journal of Biological Chemistry
July 2020
Structural and Catalytic Roles of the Human 18S rRNA Methyltransferases DIMT1 in Ribosome Assembly and Translation.
Read more.
Shorter Lab in eLife
June 2020
Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations.
Read more.
Collaborative paper between Murakami lab and Dominguez lab in Science Advances
June 2020
Cryo-EM Structure of NPF-bound Human Arp2/3 Complex and Activation Mechanism. Read more.
Lynch Lab in RNA
June 2020
Meta-Analysis of Transcriptomic Variation in T cell Populations Reveals both Variable and Consistent Signatures of Gene Expression and Splicing.
Read more.
Liu Lab in PNAS
April 2020
Coordination of mRNA and tRNA Methylations by TRMT10A.
Read more.
Lynch Lab in Nucleic Acids Research
April 2020
Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells.
Read more.
Shorter Lab studies on YouTube
April 2020
Janet Iwasa's animation of ClpP mechanism based on work from the Shorter Lab.
See more.
Vera Moiseenkova-Bell Biophysical Society Profile
April 2020
Moiseenkova-Bell shares highlights of her professional and personal background.
Read more.
Englander and Shorter Labs in PNAS
April 2020
Structural and kinetic basis for the regulation and potentiation of Hsp104 function.
Read more.
Black Lab in Science
April 2020
Structural basis for allosteric PARP-1 retention on DNA breaks.
Read more.
Kohli Lab in Angewandte Chemie
April 2020
Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation.
Read more.
Matschinsky receives Rolf Luft Award
February 2020
Congratulations Franz M. Matschinsky, MD for receiving the 2020 Rolf Luft Award from the Karolinska Institute for outstanding scientific contribution in endocrinology and diabetes.
Read more.
Garcia lab in Nature Communications
February 2020
A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry.
Read more.
Marmorstein lab in Nature Communications
February 2020
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. Read more.
Shorter and Englander labs in Journal of Biological Chemistry
February 2020
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.
Read more.
Vinogradov lab in Nanoscale
January 2020
In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing.
Read more.
Moiseenkova-Bell lab in Cell Calcium
January 2020
Structural insights into the gating mechanisms of TRPV channels.
Read more.
Marmorstein lab in Nature Structural & Molecular Biology
January 2020
Molecular basis for acetyl-CoA production by ATP-citrate lyase.
Read more.
Dreyfuss lab in Nature Communications
January 2020
U1 snRNP regulates cancer cell migration and invasion in vitro.
Read more.
Shorter lab in Molecular Cell
January 2020
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two DistinctTypes of ALS/FTD-Linked FUS Mutations.
Read more.
Lynch and Garcia labs in Genome Research
December 2019
Deep profiling and custom databases improve detection of proteoforms generated by alternative splicing.
Read more.
Murakami and Wilusz labs in PNAS
November 2019
The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation.
Read more.
Wilusz lab in Genes & Development
November 2019
The Integrator complex cleaves nascent mRNAs to attenuate transcription.
Read more.
Dreyfuss lab in Molecular Cell
November 2019
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells.
Read more.
Chang Named 2019 Packard Fellow
October 2019
Congratulations to Yi-Wei Chang for receiving the 2019 Packard Fellowship for Science and Engineering.
Read more.
Garcia lab in Nature
October 2019
Alcohol metabolism contributes to brain histone acetylation.
Read more.
Moiseenkova-Bell lab in Elife
September 2019
Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Read more.
Garcia lab in Scientific Reports
September 2019
A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins.
Read more.
Lynch lab in Cell Reports
September 2019
RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.
Read more.
Shorter lab in Cell Reports
August 2019
Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
Read more.
Garcia lab in Cancer Research
July 2019
Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors.
Read more.
Black lab in Cell
July 2019
Human Artificial Chromosomes that Bypass Centromeric DNA.
Read more.
Wilusz lab in Nucleic Acids Research
July 2019
An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3' ends.
Read more.
Dutton/Discher lab in PCCP
June 2019
Ultrafast flavin/tryptophan radical pair kinetics in a magnetically sensitive artificial protein. Read more.
Wilusz lab in Genes & Development
June 2019
Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors.
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Marmorstein and Petersson labs in Structure
May 2019
Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.
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Garcia lab in Genome Research
May 2019
One minute analysis of 200 histone posttranslational modifications by direct injection mass spectrometry.
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Sharp & Harvey labs in Biophysical Journal
April 2019
DNA Conformational Changes Play a Force-Generating Role during Bacteriophage Genome Packaging.
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Marmorstein & Black labs in JBC
April 2019
The HIRA histone chaperone complex subunit UBN1 harbors H3/H4 and DNA binding activity.
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Englander and Shorter labs in PNAS
March 2019
Walter Englander and Jim Shorter labs team up to use HX to determine dynamic behavior of Hsp104.
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Marmorstein lab in JBC
March 2019
ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis.
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Vinogradov lab in Cell Metabolism
January 2019
Sergei Vinogradov and lab develop a new faster oxygen sensor able to monitor oxygen metabolism deep in tissues.
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Garcia, Black, and Englander in Structure
November 2018
The Garcia, Black and Englander labs combine forces to achieve a high-resolution view of histone tail dynamics during nucleosome assembly.
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Shorter in Molecular Cell
August 2018
Jim Shorter and Nancy Bonini show PARP inhibitors limit TDP-43 aggregation.
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Marmorstein & Gupta in Nature Communications
August 2018
Ronen Marmorstein, Kushol Gupta and collaborators uncover the architecture of the HIRA complex required for accurate chromatin composition.
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Shorter in PNAS
June 2018
Jim Shorter helps identify more roles for amyloid fibrils in viral infection.
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Lynch Lab in Nature Communications
June 2018
Lynch Lab and colleagues identify new mechanism of splicing in the flu virus and human cells.
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Garcia awarded Biemann Medal
June 2018
Ben Garcia has been awarded the Biemann Medal by the American Society for Mass Spectrometry - one of the highest honors that the society awards, given in recognition of significant achievement in early stages of a career.
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Garcia in Cell Reports
June 2018
New LcRNAs identified in ants thanks to Mass Spectrometry and a collaborative effort between Ben Garcia and Roberto Bonasio.
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Wilusz in Genes & Development
May 2018
Congrats to the Wilusz Lab for their new paper showing how circular RNAs move to the cytoplasm.
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Shorter in Cell
April 2018
Jim Shorter and colleagues describe a new way to dissociate toxic protein aggregates. Read more.
Dutton & Moser in J. Royal Soc. Interface
April 2018
The Les Dutton and Chris Moser groups publish a new synthetic biliprotein design.
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Vinogradov & Garcia in PNAS
April 2018
Sergei Vinogradov, Ben Garcia and co-workers at Penn describe the impact of oxygen on the microbiome.
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Dean’s Innovation Award
July 2017
Congratulations to Ben Black, Professor in the department, for being the recipient of the inaugural Dean’s Innovation Award in recognition of his outstanding and creative research!