Science Signaling | July 7, 2015
Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation
By Karthik Raju, Paschalis-Thomas Doulias, Perry Evans, Elizabeth N. Krizman, Joshua G. Jackson, Oksana Horyn, Yevgeny Daikhin, Ilana Nissim, Marc Yudkoff, Itzhak Nissim, Kim A. Sharp, Michael B. Robinson, and Harry Ischiropoulos
Science Signaling 8(384):ra68
A paper from the lab of Eiko Nakamaru-Ogiso titled Apoptosis Inducing Factor (AIF) and its family member, AMID, are rotenone-sensitive NADH: ubiquinone oxidoreductases (NDH-2) has been published online in the Journal of Biological Chemistry.
A paper from Ben Black's lab has been published in the May 8, 2015 issue of Science: CENP-C reshapes and stablizes CENP-A nucleosomes at the centromere. PubMed ID: 25954010
Josh Wand was elected as a Fellow of the American Physical Society.
Ben Garcia received a Scholar Award from the Leukemia and Lymphoma Society. This award is given to investigators in the early phase of their careers to help support their research in better understanding and diagnosing cancer in the blood and lymph system, along with developing new options for prevention and treatment.
Jim Shorter and colleagues investigate the importance of the N-terminal domain of Hsp104 in dissolving prions and misfolded conformers that cause disease. This research may lead to new therapies for brain disorders and has recently been published in Molecular Cell. PennNews Release
View the 2014 Departmental and Johnson Foundation holiday card. Get a grip on entropy in 2015!
Jim Shorter received a grant from the ALS Association and the Muscular Dystrophy Association for research aimed at finding potential therapies for ALS or Lou Gehrig’s disease. This award was made possible in part by Major League Baseball’s “Ice Bucket Challenge”
The Perelman School of Medicine Class of 2017 has selected Mitch Lewis for one of the Preclinical Teaching Awards. This award, given by second year medical students, recognizes faculty that rise above the call of duty in their dedication to preclinical education.
The Department and BMB Graduate Group Retreat was held November 20-21, 2014 at Skytop Lodge in the Pocono Mountains. Photos from the event can be found here.
A collaborative study between University of Pennsylvania and The Children's Hospital of Philadelphia has been published online in Cancer Cell. The authors look for more effective treatments against childhood cancers by targeting mutations of the ALK gene. Mark Lemmon and his lab worked with Yaël P. Mossé of CHOP and Ravi Radhakrishnan of the Department of Bioengineering on the project.
PENNMedicine profiled Les Dutton in its Fall 2014 issue. The article entitled "Man of Many (P)arts" highlights his science and his artwork.
Jeremy Wilusz's work describing how a cell “decides” to make circular RNAs was recently published in Genes and Development and highlighted on the Penn Medicine News Blog site.
Journal of the American Chemical Society | October 8, 2014
Photochemical tyrosine oxidation in the structurally well-deﬁned α3Y protein: Proton-coupled electron transfer and a long-lived tyrosine radical
By Starla D. Glover, Christine Jorge, Li Liang, Kathleen G. Valentine, Leif Hammarström, and Cecilia Tommos
Journal of the American Chemical Society 136:14039-14051.
Journal of Molecular Biology | October 23, 2014
Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3
By Veronica R. Moorman, Kathleen G. Valentine, Sabrina Bédard, Vignesh Kasinath, Jakob Dogan, Fiona M. Love, A. Joshua Wand (2014)
Journal of Molecular Biology 426:3520–3538.
This year's recipient of the ASBMB Mildred Cohn Award in Biological Chemistry is Judith Klinman from the University of California, Berkeley. Previous recipients were Lila Gierasch and Jennifer Doudna. The award was established to honor the pioneering scientific accomplishments and the spirit of the late Professor Cohn. More information.
Ben Garcia's article on ‘A quantitative atlas of histone modification signatures from human cancer cells’ has won the BioMed Central Molecular and Cellular Sciences category Research Award and will now be shortlisted for the prestigious BioMed Central Research Award
Ben Garcia recently won two awards: The 2014 Pittsburgh Conference Achievement Award, sponsored by the Society for Analytical Chemists of Pittsburgh (SACP) and The Arthur F. Findeis Award for Achievements by a Young Analytical Scientist, sponsored by the American Chemical Society (ACS).
Kristen Lynch has been promoted to Professor of Biochemistry and Biophysics effective July 1, 2104.
Two new faculty members have recently joined the Department:
Ronen Marmorstein has been appointed Professor of Biochemistry and Biophysics.
Jeremy Wilusz has been appointed Assistant Professor of Biochemistry and Biophysics.
The Department premiered a short descriptive video that premiered at the Biophysical Society Meeting in San Francisco.
The Britton Chance tribute issue of Academic Radiology is pubished. The papers included in this issue were contributed following the International Symposium on Metabolic Imaging and Spectroscopy honoring the 100th birthday of Britton Chance.
The symposium, organized by Professors Lin Z. Li and Arjun Yodh, focused on scientific contributions and strategic reviews of methods to study cell and tissue function. It was held on the Penn campus in June of 2013.
Nucleic Acids Research
DAXX co-folds with H3.3/H4 using high local stability conferred by the H3.3 variant recognition residues
By Jamie E. DeNizio, Simon J. Elsässer, Ben E. Black (2014) Nucleic Acids Research 42(7):4318-4331.
Nucleic Acids Research 42(7):4318-4331.
A new portal on the Penn Medicine News Site brings together basic research finding and discoveries emerging from Penn Medicine's laboratories. These advances will impact the treatment of a wide varieties of diseases and provide the foundation on which many of medicine's next cures will be based. Highlighted in the RNA section is work done by the Gideon Dreyfuss, James Shorter, Kristin Lynch, and Yale Goldman.
Les Dutton won a 2013 John Scott Award. This award dates back to 1822 and has been given to men and women who, by their inventions, have contributed in some outstanding way to the “comfort, welfare, and happiness of mankind”. Les was chosen for his work on the “elementary processes of oxidation-reduction and the diverse biological events coupled to it.”
WHYY/Newsworks article by Faye Flam
Penn Medicine News Release
Renaissance Biochemist (Penn Medicine News Blog)
Rahul Kohli, and his team lead by BMB student Charlie Mo, won one of the first GlaxoSmithKline "Discovery Fast Track" Awards, designed to translate academic research into starting points for new potential medicines.
Department and BMB Graduate Group Retreat was held November 7 - 8, 2013 at Skytop Lodge in the Pocono Mountains. Photographs from the 2-day event are online.
Departmental photograph was taken on October 31.
Jim Shorter is the recipient of a prestigious research grant from the the Muscular Dystrophy Association (MDA) for his work on generating therapeutic disaggregases for amyotrophic lateral sclerosis (ALS). Read more
Mark Lemmon was awarded funding from the Samuel Waxman Cancer Research Foundation for his work focusing on HER family kinases and oncogene addiction in brain cancer.
Gideon Dreyfuss, Isaac Norris Professor of Biochemistry & BIophysics, and HHMI Investigator, has been elected to the Institute of Medicine. Membership in the IOM is considered to be one of the highest honors in biomedicine.
Les Dutton has won a 2013 John Scott Award. This award dates back to 1822 and has been given to men and women who, by their inventions, have contributed in some outstanding way to the “comfort, welfare, and happiness of mankind”. Les was chosen for his work on the “elementary processes of oxidation-reduction and the diverse biological events coupled to it.” The John Scott Award ceremony will be held in November 2013.
The International Symposium on Imaging and Metabolic Spectroscopy honoring the Centennial of Britton Chance's birth held at the University of Pennsylvania on June 18-19, 2013
Jim Shorter promoted to Associate Professor of Biochemistry and Biophysics effective July 1, 2013.
The life of Paul Mueller, who was Research Professor of Biochemistry and Biophysics from 1981 - 1992, was remembered at a "Meeting of the Friends of Paul Mueller" on Friday, May 10, 2013. Dr. Mueller was one of the pioneers of the field of lipid bilayers, as well as neuromorphic engineering, bioinspired smart electronics and biomimetic systems. Penn Alamanac Obituary
A Retrospective of Annemarie Weber by Clara Franzini-Armstrong published in ASBMB Today. (See page 16-18)
Jim Shorter won 2012 Michael S. Brown New Investigator Research Award, which recognizes emerging faculty engaged in innovative discoveries.
Rahul Kohli received a NIH Director’s New Innovator Award.
Annemarie Weber (1923-2012). Read more
Cell | July 6, 2012
U1 snRNP Determines mRNA Length and Regulates Isoform Expression
By Michael G. Berg, Larry N. Singh, Ihab Younis,Qiang Liu, Anna Maria Pinto, Daisuke Kaida, Zhenxi Zhang, Sungchan Cho, Scott Sherrill-Mix, Lili Wan, and Gideon Dreyfuss
Trends in Biochemical Sciences | June, 2012
Molecular Underpinnings of Centromere Identity and Maintenance
by Nikolina Sekulic and Ben Black
Mitch Lewis received a 2012 Christian R. and Mary F. Lindback Award for Distinguished Teaching, Penn's highest teaching honor.