banner link to Perelman School of Medicine Biochemistry and Biophysics
biochemistry and biophysics



Fuglestad B, Stetz MA, Belnavis Z, Wand AJ. Solution NMR investigation of the response of the lactose repressor core domain dimer to hydrostatic pressure. Biophys Chem. 2017 Dec; 231: 39-44.
PMID: 28249763

Simithy J, Sidoli S, Yuan ZF, Coradin M, Bhanu NV, Marchione DM, Klein BJ, Bazilevsky GA, McCullough CE, Magin RS, Kutateladze TG, Snyder NW, Marmorstein R, Garcia BA. Characterization of histone acylations links chromatin modifications with metabolism. Nat Commun. 2017 Oct 26;8(1):1141.
PMID: 29070843

Karch KR, Langelier MF, Pascal JM, Garcia BA. The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage. Mol Biosyst. 2017 Nov 21;13(12):2660-2671.
PMID: 29058739

Doliba NM, Liu Q, Li C, Chen P, Liu C, Naji A, Matschinsky FM. Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor. Mol Metab. 2017 Oct;6(10):1240-1253.
PMID: 29031723

Wilson DF. Oxidative phosphorylation: regulation and role in cellular and tissue metabolism. J Physiol. 2017 Dec 1;595(23):7023-7038.
PMID: 29023737

Magin RS, Deng S, Zhang H, Cooperman B, Marmorstein R. Probing the interaction between NatA and the ribosome for co-translational protein acetylation. PLoS One. 2017 Oct 10;12(10):e0186278.
PMID: 29016658

Emptage RP, Schoenberger MJ, Ferguson KM, Marmorstein R. Intramolecular autoinhibition of Checkpoint Kinase 1 is mediated by conserved basic motifs of the C-terminal Kinase Associated-1 domain. J Biol Chem. 2017 Sep 25.
PMID: 28972186

Oh JM, Di C, Venters CC, Guo J, Arai C, So BR, Pinto AM, Zhang Z, Wan L, Younis I, Dreyfuss G. U1 snRNP telescripting regulates a size-function-stratified human genome. Nat Struct Mol Biol. 2017 Nov;24(11):993-999.
PMID: 28967884

Kori Y, Sidoli S, Yuan ZF, Lund PJ, Zhao X, Garcia BA. Proteome-wide acetylation dynamics in human cells. Sci Rep. 2017 Aug 31;7(1):10296.
PMID: 28860605

Iwata-Otsubo A, Dawicki-McKenna JM, Akera T, Falk SJ, Chmátal L, Yang K, Sullivan BA, Schultz RM, Lampson MA, Black BE. Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis. Curr Biol. 2017 Aug 7;
PMID: 28756949

Wilson DF, Cember ATJ, Matschinsky FM. The thermodynamic basis of glucose-stimulated insulin release: a model of the core mechanism. Physiol Rep. 2017 Jun;5(12). pii: e13327.
PMID: 28655753

Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE. Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition. Nat Commun. 2017 Jun 9;8:15775.
PMID: 28598437

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 2017 Jul 21;357(6348):273-279. PMID: 28619716

Caro JA, Harpole KW, Kasinath V, Lim J, Granja J, Valentine KG, Sharp KA, Wand AJ. Entropy in molecular recognition by proteins. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6563-6568. PMID: 28584100

Gupta K, Sharp R, Yuan JB, Li H, Van Duyne GD. Coiled-coil interactions mediate serine integrase directionality. Nucleic Acids Res. 2017 Jul 7;45(12):7339-7353.
PMID: 28549184

Gazzara MR, Mallory MJ, Roytenberg R, Lindberg JP, Jha A, Lynch KW, Barash Y. Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes. Genome Res. 2017 Aug;27(8):1360-1370
PMID: 28512194

Jackrel ME, Shorter J. Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease. Front Neurosci. 2017 Feb 28;11:99. PubMed
PMID: 28293166

Kodali G, Mancini JA, Solomon LA, Episova TV, Roach N, Hobbs CJ, Wagner P, Mass OA, Aravindu K, Barnsley JE, Gordon KC, Officer DL, Dutton PL, Moser CC. Design and engineering of water-soluble light-harvesting protein maquettes. Chem Sci. 2017 Jan 1;8(1):316-324.
PMID: 28261441

Fuglestad B, Stetz MA, Belnavis Z, Wand AJ. Solution NMR investigation of the response of the lactose repressor core domain dimer to hydrostatic pressure. Biophys Chem. 2017 Dec;231:39-44.
PMID: 28249763

Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE. CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell. 2017 Jan 9;40(1):104-113.
PMID: 28073008

Stankovic A, Guo LY, Mata JF, Bodor DL, Cao XJ, Bailey AO, Shabanowitz J, Hunt DF, Garcia BA, Black BE, Jansen LE. A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly. Mol Cell. 2017 Jan 19;65(2):231-246.
PMID: 28017591


Smoak EM, Stein P, Schultz RM, Lampson MA, Black BE (2016) Long-term retention of CENP-A nucleosomes in mammalian oocytes underpins transgenerational inheritance of centromere identity. Curr Biol. 26(8):1110-1116. doi: 10.1016/j.cub.2016.02.061.

Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA (2016) A novel quantitative mass spectrometry platform for determining protein O-GlcNAcylation dynamics. Mol Cell Proteomics pii: mcp.O115.049627.

So BR, Wan L, Zhang Z, Li P, Babiash E, Duan J, Younis I, Dreyfuss G (2016) A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange. Nat Struct Mol Biol. 23(3):225-230. doi: 10.1038/nsmb.3167.

Falk SJ, Lee J, Sekulic N, Sennett MA, Lee TH, Black BE (2016) CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres. Nat Struct Mol Biol. 23(3):204-208. doi: 10.1038/nsmb.3175.

Han Y, Yuan ZF, Molden RC, Garcia BA (2016) Monitoring cellular phosphorylation signaling pathways into chromatin and down to the gene level. Mol Cell Proteomics. 15(3):834-853. doi: 10.1074/mcp.M115.053421.

Hu W, Kan ZY, Mayne L, Englander SW (2016) Cytochrome c folds through foldon-dependent native-like intermediates in an ordered pathway. Proc Natl Acad Sci USA. pii: 201522674.

Sharp KA (2016) Unpacking the origins of in-cell crowding. Proc Natl Acad Sci USA 2016 113(7):1684-1685. doi: 10.1073/pnas.1600098113.

Crawford DJ, Liu MY, Nabel CS, Cao XJ, Garcia BA, Kohli RM (2016) Tet2 catalyzes stepwise 5-methylcytosine oxidation by an iterative and de novo mechanism. J Am Chem Soc. 138(3):730-733. doi: 10.1021/jacs.5b10554.


Sochor MA, Vasireddy V, Drivas TG, Wojno A, Doung T, Shpylchak I, Bennicelli J, Chung D, Bennett J, Lewis M (2015) An autogenously regulated expression system for gene therapeutic ocular applications. Sci Rep. 5:17105. doi: 10.1038/srep17105.

Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD (2015) Structure of an RNA polymerase II preinitiation complex. Proc Natl Acad Sci USA. 112(44):13543-13548. doi: 10.1073/pnas.1518255112.

Kramer MC, Liang D, Tatomer DC, Gold B, March ZM, Cherry S, Wilusz JE (2015) Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins. Genes Dev. 29(20):2168-2182. doi: 10.1101/gad.270421.115.

Martinez NM, Agosto L, Qiu J, Mallory MJ, Gazzara MR, Barash Y, Fu XD, Lynch KW (2015) Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation. Genes Dev. 29(19):2054-2066.
doi: 10.1101/gad.267245.115.

Ricketts DM, Frederick B, Hoff H, Tang Y, Schultz DC, Singh Rai T, Grazia Vizioli M, Adams PD, Marmorstein R (2015) Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex. Nat Commun. 6:7711. doi: 10.1038/ncomms8711.

Logsdon GA, Barrey EJ, Bassett EA, DeNizio JE, Guo LY, Panchenko T, Dawicki-McKenna JM, Heun P, Black BE (2015) Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J Cell Biol. 208(5):521-531. doi: 10.1083/jcb.201412011.

Kasinath V, Fu Y, Sharp KA, Wand AJ (2015) A sharp thermal transition of fast aromatic-ring dynamics in ubiquitin. Angew Chem Int Ed Engl. 54(1):102-107. doi: 10.1002/anie.201408220. PMID:25476230

Castellano LM, Bart SM , Holmes VM, Weissman D, Shorter J (2015) Repurposing Hsp104 to antagonize seminal amyloid and counter HIV infection. Chemistry & Biology 22(8):1074–1086.

Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner F-G, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J (2015) A molecular tweezer antagonizes seminal amyloids and HIV infection. eLife eLife 2015;4:e05397

Raju K, Doulias P-T, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim Il, Yudkoff M, Nissim It, Sharp KA, Robinson MB, Ischiropoulos H (2015) Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. Sci Signal 8(384):ra68

Elguindy MM, Nakamaru-Osigo E (2015) Apoptosis Inducing Factor (AIF) and its family member, AMID, are rotenone-sensitive NADH: ubiquinone oxidoreductases (NDH-2). J Biol Chem 290(34):20815-20826. doi: 10.1074/jbc.M115.641498. Epub 2015 Jun 10.

Sweeny, EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, and Shorter J (2015) The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol Cell 57(5):836-849.

Falk SJ, Guo LY, Sekulic N, Smoak EM, Mani T, Logsdon GA, Gupta K, Jansen LET, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE (2015) CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science 348(6235):699-703.
PMID: 25954010

Mallory MJ, Allon SJ, Qiu J, Gazzara MR, Tapescu I, Martinez NM, Fu XD, Lynch KW (2015) Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling. Proc Natl Acad Sci USA 112(17):E2139-148.
PMID: 25870297


blank pixel

July 7 2015 Science SignalingJuly 7, 2015 issue of Science Signaling with cover image by Kim Sharp

October 8, 2014 issue of Journal of the American Chemical Society with cover story by Tommos lab

2014 Wand Lab cover JMB
October 23, 2014 issue of Journal of Molecular Biology with cover story by the Wand lab

Black_2014_NARVolume 42 (2014) of Nucleic Acids Research with cover story by the Black Lab

Cell July 6, 2012July 6, 2012 issue of Cell with cover story by Dreyfuss lab

Cell July 6, 2012June 2012 issue of Trends in Biochemical Sciences with cover story by the Black lab.

Nature Structural Biology Cover Feb 2011February 2012 issue of Nature Structural & Molecular Biology with cover story by Wand lab

Molecular Cell 2010January 29, 2010 issue of Molecular Cell with cover story by Lynch lab

Nature Chemical BiologyMay 2010 issue of Nature Chemical Biology with cover story by Wand lab