1. The poster sessions will be held in Clothier Hall (see campus map for location)
  2. Easels, poster boards (40" X 60"), and push pins will be provided on site.
  3. All posters should be set up on Thursday morning between 8:45 and 9:30 a.m., and remain in place for all three sessions.
  4. Each poster will be assigned a specific session in which it is "presented" (e.g., II-4 indicates Session II, which is Thursday afternoon).
  5. Poster Session III is on Friday morning from 10:20 a.m. to 12:00 noon. All posters should be removed immediately after this session, between 12:00 noon and 12:30 p.m. Please break down your easel and take it and the poster board to the designated area near the food tables in Clothier. Please make sure that no pushpins are on the floor in your area and do not leave any pushpins on the poster boards, but return them to the setup table.
  6. The Department of Biochemistry and Biophysics will be awarding cash prizes for the top three posters with a graduate student as the first author. The posters will be judged by a small faculty committee and the awards presented in the Science Center on Friday afternoon, immediately following the last talk.

    7.  

    Poster Session I: Thursday, June 14: 12:30 – 2:30 p.m.

    Poster Session II: Thursday, June 14: 5:30 – 7:00 p.m.

    Poster Session III: Friday, June 15: 10:20 a.m. – 12:00 noon

    #I-1

    Capraro, Benjamin R. and Tobias Baumgart. Kinetic studies of endophilin-membrane interactions.
    #II-1

    Dersh, Devin C. and Yair Argon. Molecular chaperones in ER quality control.
    #III-1

    Chen, Helen, Wenyun Lu, Joshua Rabinowitz and Morris J. Birnbaum. Metabolic flux analysis in normal and obese liver.

    #I-2

    Crescenzi, Rachelle, Sanjana Reddy, Mohammed Haris, Hari Hariharan, Ravinder Reddy and Ari Borthakur. Glutamate alterations in a mouse model of tauopathy.
    #II-2

    Salimian, Kevan J., Tanya Panchenko, Dan Hasson, Peter E. Warburton and Ben E. Black. Genomic approaches for studying centromeric chromatin.
    #III-2

    Rice, Cory T. and Theresa M. Busch. The biological and molecular effects of photodynamic therapy on mesothelioma: a murine study of AB12 tumors.
    #I-3

    Zhang, Shaoqing, Dan W. Kulp, Chaim A. Schramm, Alessandro Senes and William F. DeGrado. Structural and sequence motifs in the helix-helix interactions.
    #II-3

    Seither, Katelyn M., Heather A. McMahon, Mimi Cushman, Geronda L. Montalvo, William F. DeGrado and James Shorter. Targeting Ab42 and Ab43 aggregation with aromatic foldamers and small molecules.
    #III-3

    Babiash, Eric S. and Gideon Dreyfuss. A minimal system for spliceosomal snRNP’s Sm core biogenesis.
    #I-4

    Ennist, Nathan M., Tammer A. Farid, Goutham Kodali and P. Leslie Dutton. Design and characterization of a multi-cofactor binding protein with implications for photoactivated charge separation.
    #II-4

    Rivera-Santiago, Roland F., Suk Namgoong and Roberto Dominguez. Structural and functional studies of complementary regions in actin nucleation.
    #III-4

    Tsai, Pei-Fang, Robert J. Lake and Hua-Ying Fan. Bookmarking the genome: the role of the transcription factors CBF1 in mitosis.
    #I-5

    Chiou, Ni-ting, Ganesh Shankarling and Kristen W. Lynch. Repression of NTC recruitment and exon splicing by an hnRNP network that alters spliceosomal interactions upstream of the 5’ splice site.
    #II-5

    Huoh, Yu-San and Kathryn M. Ferguson. The molecular basis of substrate recognition by the E3 ubiquiting ligase Pellino.
    #III-5

    Sekulic, Nikolina, Kushol Gupta, Gregory D. Van Dyne and Ben E. Black. SAXS and SANS on CENP-A nucleosome in solution.
    #I-6

    Sochor, Matthew A. and Mitchell Lewis. Re-wiring the lac operon: creating a hypoxanthine binding, self regulated switch to fight Lesch-Nyhan Disease.
    #II-6

    Dadosh, Tali, Lisa G. Lippert, Benjamin T. Diroll, Christopher B. Murray and Yale E. Goldman. Polarized emission of CdSe nanorods to probe three-dimensional structural dynamics of single motor protein molecules.
    #III-6

    Sheehan, Molly M., Lee A. Solomon, J.L. Ross Anderson, P. Leslie Dutton and Christopher C. Moser. Design and engineering of a molecular system for the study of ROS production in proteins.
    #I-7

    Sung, Julie C. and James Shorter. TNPO1 rescue of FUS toxicity in vivo.
    #II-7

    Ajith, Sandya, Michael J. Mallory, Jason Jackson and Kristen W. Lynch. Investigating the mechanism by which CELF2 regulates LEF1 alternative splicing.
    #III-7

    Park, Jin H., Yingting Liu, Ravi Radhakrishnan and Mark A. Lemmon. Structure studies of EGFR kinase domain with inhibitor.
    #I-8

    Akl, Adam, Ravi Amaravadi and David W. Speicher. Proteomics analysis of autophagy-related secretion in melanoma.

    #II-8

    Ricciuti, Alec J., Elizabeth A. Sweeny, Morgan E. DeSantis, Benjamin T. Walters, Zhong-Yuan Kan, Ian Dunn, Leland Mayne, James Shorter and S. Walter Englander. Hsp104 structure and dynamics throughout the hydrolysis cycle.
    #III-8

    Nucci, Nathaniel V., Igor Dodevski and A. Joshua Wand. Recent advances in NMR spectroscopy of encapsulated proteins in low viscosity fluids.
    #I-9

    Mani, Tomoyasu and Sergei A. Vinogradov. Magnetic field effects on phosphorescence: triplet states and radical pair dynamics.
    #II-9

    Soo, Michael Y., Aaron D. Gitler and James Shorter. Defining the Hsp104 folding reservoir.
    #III-9

    Nucci, Nathaniel V., Veronica R. Moorman, John M. Gledhill, Kathleen G. Valentine and A. Joshua Wand. Effects of confinement on the fast dynamics of ubiquitin.
    #I-10

    Slochower, David R., Peter J. Huwe, Ryan Bradley, Ravi Radhakrishnan and Paul A. Janmey. Molecular dynamics simulations of monolayers and membranes with phosphatidylinositol bisphosphate (PIP2).
    #II-10

    Montalvo, Geronda L., Yao Zhang and William F. DeGrado. de novo design of self-assembling foldamers that inhibit heparin-protein interactions.
    #III-10

    Wilson, David F., David K. Harrison and Sergei A. Vinogradov. Oxygen, pH, and oxidative phosphorylation.
    #I-11

    Li, Lin Z., He N. Xu, Shoko Nioka and Britton Chance. Mitochondrial redox state and its potential link to tumor metastatic potential.

    #II-11

    Solomon, Lee A., Goutham Kodali, Christopher C. Moser and P. Leslie Dutton. Physical chemical principles of holoprotein assembly.
    #III-11

    Smoak, Evan M., Samantha J. Falk, Michael A. Lampson and Ben E. Black. Dissecting the epigenetic propagation of the centromere: CENP-A during S-phase.
    #I-12

    Turegun, Bengi, David Kast and Roberto Dominguez. Arp7 and Arp9 heterodimerize to bind SWI-SNF chromatin-remodeling proteins.

    #II-12

    Fry, Bryan A., Geetha N. Goparaju, Himanshu Saraf, Gregory R. Wiedman, Christopher C. Moser, P. Leslie Dutton and Bohdana M. Discher. Engineering electron transport in synthetic amphiphilic transmembrane proteins.
    #III-12

    Rutherford, Karen, Kushol Gupta and Gregory D. Van Duyne. Structural characterization of a large serine recombinase.
    #I-13

    Castellano, Laura M., Veronica Holmes, Drew Weissman and James Shorter. Fighting HIV infection by defining mechanisms to disaggregate SEVI amyloid fibrils.
    #II-13

    Getchell, Samuel E., Heather Martin, Elizabeth Yeh, Ann Vernon Grey, Jason Jung and Lewis A. Chodosh. Biochemistry of Hunk kinase.
    #III-13

    Zelent, Bogumil, Carol W. Buettger, Pan Chen, Charles A. Stanley, A. Joshua Wand and Franz M. Matschinsky. Glucokinase stability as influenced by the substrate glucose and the osmolites glycerol and urea.
    #I-14

    Sweeny, Elizabeth A., Beatrice Razzo, Kushol Gupta, Matthew A. Sochor, Gregory D. Van Duyne and James Shorter. Structure and mechanism of Hsp104.

    #II-14

    Wu, Neo (Zhengyi) and Mark A. Lemmon. EGFR-mediated ensemble of signaling molecules.
    #III-14

    Walters, Benjamin T., Leland Mayne and S. Walter Englander. The folding pathway and structural dynamics of maltose binding protein.
    #I-15

    Jackrel, Meredith E. and James Shorter. Engineering Hsp104 to disaggregate diverse substrates.
    #II-15

    Ohnishi, Tomoko, S. Tsuyoshi Ohnishi, Kyoko Shinzawa-Itoh, Shinya Yoshikawa and Ralph T. Weber. EPR detection of two protein-associated ubiquinone components (SQ-Nf and SQ-Ns) in the membrane in situ and in proteoliposomes of isolated bovine heart complex I.
    #III-15

    Yarosh, Christopher, A., James Lipchock and Kristen W. Lynch. Investigating the regulation of PSF in signal-induced T cell alternative splicing.
    #I-16

    Martínez-Rivera, Melissa C., Bruce W. Berry and Cecilia Tommos. Electrochemical studies of a tyrosyl radical in a protein system.

    #II-16

    Kodali, Goutham, Tammer A. Farid, Lee A. Solomon, ... and P. Leslie Dutton. Single designed protein platform with multiple functionalities: oxidoreductase, oxygen transport, light-harvesting, and light activated electron transfer.
    #III-16

    Artim, Stephen C., Jeannine M. Mendrola and Mark A. Lemmon. Structural determination of TrkA and Ror2 receptor tyrosine kinases.
    #I-17

    Cho, Il-taeg, Pei-Fang Tsai, Robert J. Lake, Asjad Basheer and Hua-Ying Fan. ATP-dependent chromatin remodeling by the CSB protein and NAP1-like chaperones is crucial for transcription-coupled DNA repair and transcription.
    #II-17

    Martinez, Nicole M. and Kristen W. Lynch. Signal-induced alternative splicing regulation in T-cell activation.

    #III-17

    Wang, Hejia Henry and James Shorter. Defining how Kapb2 affects FUS aggregation.
    #I-18

    Mo, Charlie Y. and Rahul M. Kohli. Elucidating the substrate preference of the bacterial SOS regulator LexA.
    #II-18

    Goparaju, Geetha N., Ye Lu, Himanshu Saraf, P. Leslie Dutton, A.T. Charlie Johnson and Bohdana Discher. Artificial membrane protein maquettes for understanding natural oxidoreductases and designing functional surfaces.
    #III-18

    Li, Huiguang, Young Hwang, Kushol Gupta, Frederic D. Bushman and Gregory D. Van Duyne. Crystallization and preliminary X-ray analysis of poxvirus resolvase.
    #I-19

    Moore, Jason, Kathryn M. Ferguson and Mark A. Lemmon. Tie2 receptor dimerization is mediated by its extracellular FNIII domains.
    #II-19

    Cole, Brian S., Ganesh Shankarling and Kristen W. Lynch. Differential transcriptome occupancy of hnRNP L upon T cell stimulation revealed by computational genomics.
    #III-19

    Ballister, Edward R., Zachary Feldman, David M. Chenoweth and Michael A. Lampson. Rapamycin revisited: improving inducible dimerization.
    #I-20

    Smith, Sarah A., Alan Tong, Ni-ting Chiou and Kristen W. Lynch. Refining the ARS: activation-responsive splicing regulation by hnRNP L and hnRNP LL.

    #II-20

    Shroder, Deborah Y., John Beausang and Yale E. Goldman. Detecting conformational changes in myosin V.
    #III-20

    Tourdot, Richard, Jin Liu and Ravi Radhakrishnan. Mesoscale simulations of curvature inducing protein partitioning in the presence of mean curvature gradients.
    #I-21

    Nabel, Christopher S., Laura C. Wang and Rahul M. Kohli. The molecular basis for selective deamination of DNA over RNA by AID/APOBEC enzymes is determined by nucleotide sugar pucker and flexibility.
    #II-21

    Meinhardt, Nataline D., Swapnil Kulkarni, Hyunil Jo, Melanie Millholland, William F. DeGrado and Doron C. Greenbaum. Building specific inhibitors and activity-based probes of calpain by mimicking a natural protein alpha-helix interaction.

    #III-21

    Williams, Laura A., Travis Walton, Elicia Preston, Arjun Raj and John I. Murray. Understanding how transient global expression of FKH-4 and other similar transcription factors contributes to coordination of C. elegans embryogenesis.

    #I-22

    Nabel, Christopher S., Huijue Jia, Yu Ye, Li Shen, Hana Goldshmidt, James T. Stivers, Yi Zhang and Rahul M. Kohli. AID/APOBEC enzymes discriminate against bulky 5-substituted cytosines for deamination: implications for DNA demethylation.
    #II-22

    Bagchi, Atrish, Nicholas J. Bessman, Mark A. Lemmon and Kathryn M. Ferguson. Insights into EGFR activation and autoinhibition through an analysis of glioblastoma-linked somatic mutations in its extracellular domains.
    #III-22

    Huwe, Peter J. and Ravi Radhakrishnan. Understanding kinase activating ALK mutants in neuroblastoma patients.
    #I-23

    Howard, Kathleen P., Kei Saotome and Mary Alice Upshur. SDSL reveals cholesterol dependent conformational shift of influenza A M2 protein.

    #II-23

    Shi, Fumin and Mark A. Lemmon. Biophysical characterization of derailed-Wnt interaction.
    #III-23

    DeSantis, Morgan E., Elizabeth A. Sweeny and James Shorter. The role of the middle domain of Hsp104 in chaperone collaboration.
    #I-24

    Tang, Yong, Aastha Puri, M. Daniel Ricketts, Taranjit Singh Rai, Jason Hoffmann, Elise Hoi, Peter D. Adams, David C. Schultz and Ronen Marmorstein. Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.
    #II-24

    Stetz, Matthew A. and A. Joshua Wand. Preliminary NMR-based characterization of the lac repressor protein.
    #III-24

    Doliba, Nicolai M., Deborah Fenner, Wei Qin, Bogumil Zelent, Chengyang Liu, David F. Wilson, Ali Naji, Joseph Bass, Ramakanth Sarabu and Franz M. Matschinsky. Repair of diverse diabetic defects of beta-cells in man and mouse by pharmacological glucokinase activation.
    #I-25

    Eletto, Davide, Avinash Maganty, Daniela Eletto, Devin Dersh, Catherine Makarewich, Chhanda Biswas, Shirin Doroudgar, Christopher C. Glembotski and Yair Argon. Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.
    		 
    This Retreat is open to the public. Therefore, posters or presentations given at this event are public disclosures and may negatively impact the University of Pennsylvania’s ability to protect the work under intellectual property law. If you feel the work may be of commercial interest or plan to disclose it to Penn’s Center for Technology Transfer in the future, CTT encourages you to disclose it to their office at least one month prior to this event.