Department of Biochemistry and Biophysics

and the Graduate Group in Biochemistry and Molecular Biophysics


* Poster presenter
Names of students eligible for poster prizes are underlined

  1. Shroder, Deborah Y.*, Yujie Sun, Osamu Sato, Mitsuo Ikebe and Yale E. Goldman. Dynamics of myosin XI: the family speed demon.
  2. Doliba, Nicolai M.*, Qin Liu, Pan Cheng, Changhong Li, Chengyang Liu, Patrick Seale, Ali Naji, David F. Wilson and Franz M. Matschinsky. Chronic effects of fatty acids on insulin secretion, oxygen consumption, intracellular calcium signaling and gene expression profile in mouse and human pancreatic islets.
  3. Rivera-Santiago, Roland F.*, Grzegorz Rebowski, Malgorzata Boczkowska and Roberto Dominguez. Characterization of the C1-M-C2 region of cMyBP-C.
  4. Sheehan, Molly M.*, Christopher C. Moser and P. Leslie Dutton. Design of a highly stable protein platform for engineering enzymes.
  5. Ajith, Sandya*, Michael J. Mallory and Kristen W. Lynch. Control of CELF2 in T cell activation and its regulation of LEF1 alternative splicing.
  6. Goparaju, Geetha N., Bryan A. Fry, Christopher C. Moser, P. Leslie Dutton and Bohdana M. Discher*.  Design and characterization of a single chain amphiphilic maquette for membrane insertion and electron transfer.
  7. Sweeny, Elizabeth A.*, Zhongyuan Kan, Matthew A. Sochor and James Shorter. X-ray footprinting as a probe of Hsp104 solvation.
  8. Shankarling, Ganesh*, Brian S. Cole*, Michael J. Mallory and Kristen W. Lynch. Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T-cells.
  9. Zhao, Zhenyu*, Christopher C. Moser and P. Leslie Dutton. Construction of a proof-of-principle triad charge separating device in maquette.
  10. Martinez, Nicole M.* and Kristen W. Lynch. T cell activation and the JNK pathway: from signaling to splicing and back.
  11. Mancini, Joshua A.*, Goutham Kodali, Lee A. Solomon, Nicholas Roach, J.L. Ross Anderson, Jingjie Yu, Bruce R. Lichtenstein, Tatiana V. Esipova, Sergei A. Vinogradov, Pawel Wagner, Olga A. Mass, Jonathan Lindsey. Bohdana M. Discher, David L. Officer, Himadri Pakrasi, Christopher C. Moser and P. Leslie Dutton. Engineering light-harvesting maquettes both in vitro and in vivo.
  12. Guo, Lin*, Hejia Wang, Nikita Singh and James Shorter. Defining Kapβ2 as a protein disaggregase for ALS disease protein: FUS.
  13. Chen, Xing*, Jacob M. Goldberg, Nataline D. Meinhardt, Doron C. Greenbaum and E. James Petersson.  Thioamide-based fluorescent protease sensors.
  14. Moore, Jason O.*, Kathryn M. Ferguson and Mark A. Lemmon. Tie2 receptor dimerization mediated by its extracellular FNIII domains.
  15. Huwe, Peter J.*, Scott C. Bresler, Jin H. Park, Daniel A. Weiser, Yaël P. Mossé, Mark A. Lemmon and Ravi Radhakrishnan. Computational investigations of mutation-driven ALK kinase activation in neuroblastoma patients.
  16. Logsdon, Glennis A.*, Nikolina Sekulic and Ben E. Black.  Alterations of the CENP-A nucleosome by CENP-C.
  17. Rice, Cory T.*, Christopher F. Bryan, Michael Harkisheimer, David C. Schultz and Emmanuel Skordalakes. Structure of the human telomeric Stn1-Ten1 complex and its role at telomeres.
  18. O’Brien, Evan S.*, Nathaniel V. Nucci, Kathleen G. Valentine and  A. Joshua Wand. NMR structure of cytochrome c and interactions with cardiolipin in reverse micelles.
  19. Jorge, Christine*, Nathaniel V. Nucci, Gurnimrat Sidhu and A. Joshua Wand. Protein hydration in reverse micelles.
  20. Pinto, Anna Maria*, Jung-Min Oh, Lili Wan, Byung Ran So, Wei Wang, Michael G. Berg, Ihab Younis, Zhenxi Zhang, Christopher Venters, Zhi Wei and Gideon Dreyfuss. Bi-directional U1 snRNP regulation of 3’UTR length, oncogenes expression and cancer cell phenotype.
  21. Zelent, Bogumil*, Anne Raimondo, Amy Barrett, Carol W. Buettger, Pan Chen, Anna L. Gloyn and  Franz M. Matschinsky. Analysis of cooperative Interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence.
  22. Mo, Charlie Y.*, Dillon L. Birdwell and Rahul M. Kohli. Understanding and targeting the repressor-protease LexA, a regulator of bacterial stress and evolution.
  23. Yarosh, Christopher A.*, James M. Lipchock and Kristen W. Lynch. GSK3/TRAP150-mediated regulation of the multifunctional RNA-binding protein PSF.
  24. Zakharov, Pavel*,  Natalia Dashkevich, Fazly Ataullakhanov, Iain Cheeseman and Ekaterina L. Grishchuk. The kinetochore Ska1 complex enhances the ability of the Ndc80 complex to couple microtubule disassembly with force production.
  25. Sharp, Kim A.*, Vignesh Kasinath and A. Joshua Wand. Proteins have it all: magnets, heat and entropy.
  26. Stetz, Matthew A.*, Marie V. Carter, Jack Wee Lim, Kathleen G. Valentine and A. Joshua Wand. Revisiting allostery in the lac repressor protein.
  27. Kasinath, Vignesh*, Kim A. Sharp and A. Joshua Wand. Microscopic insights into the NMR relaxation based protein conformational entropy meter.
  28. Babiash, Eric S.* and Gideon Dreyfuss. Minimal SMN complexes.
  29. Artim, Stephen C.*, Jeannine M. Mendrola and Mark A. Lemmon. Kinase autoinhibition mechanisms in the insulin receptor kinase subfamily.
  30. Wilusz, Jeremy E.* Changing dogmas of RNA processing mechanisms.
  31. Schulte, Jane E.*, Conor S. O’Brien, Kelly E. O’Quin, Matthew A. Conte and Karen L. Carleton. The retinal homeobox gene Rx1 genetically controls opsin expression and contributes to the
    diversity of African cichlid fishes.
  32. Soo, Michael Y.* and James Shorter. Defining the Hsp104 folding reservoir.
  33. Dersh, Devin C.*, Stephanie Jones, Davide Eletto, John Christianson and Yair Argon. Aberrant glycosylation induces altered conformation and degradation of the ER-resident HSP90, GRP94.
  34. Li, Huiguang*, Young Hwang, Kushol Gupta, Frederic D. Bushman and Gregory D. Van Duyne. Crystal structure of pox-virus resolvase.
  35. Ugras, Scott E.* and Harry Ischiropoulos. Alpha synuclein aggregation and phosphorylation signaling in the brain.
  36. Wilson, David F.* Regulation of cellular metabolism: programming and maintaining metabolic homeostasis.
  37. Turegun, Bengi*, David J. Kast and Roberto Dominguez. Structural role of subunit Rtt102 in SWI/SNF chromatin-remodeling complexes.
  38. Speer, Kelsey F.*, Peter S. Klein and Mark A. Lemmon. Investigating the interactions of Wnt ligands with their cell surface receptors.
  39. Bialas, Christopher P.*, Goutham Kodali, Christopher C. Moser and P. Leslie Dutton. The engineering of non natural flavoproteins.
  40. Ricketts, M. Daniel* and Ronen Marmorstein. Molecular basis for histone H3.3-specific deposition by the HIRA/UBN1/CABIN1/ASF1a (HUCA) histone chaperone complex.
  41. Park, Jin H.*, Scott C. Bresler, Peter J. Huwe, Ravi Radhakrishnan, Yaël P. Mossé and Mark A. Lemmon. Regulation and inhibition of anaplastic lymphoma kinase.
  42. Meinhardt, Nataline D.*, Swapnil Kulkarni, Emily K. Schutsky, Hyunil Jo and Doron C. Greenbaum. Design of a-helical cysteine protease inhibitors.
  43. Remsberg, Jarrett R.*, Sean Armour, Zheng Sun, Zuo-Fei Yuan, Benjamin A. Garcia and Mitchell A. Lazar. The structural role and contribution of histone deacetylase 3 in the nuclear receptor corepressor complex.
  44. Welsh, John D.*, Timothy J. Stalker, Roman Voronov, Ryan W. Muthard, Maurizio Tomaiuolo, Scott L. Diamond and Lawrence F. Brass. Interplatelet molecular transport regulates platelet activation during thrombus formation in vivo.
  45. Ricciuti, Alec J.*, Benjamin T. Walters, Elizabeth A. Sweeny, Morgan E. DeSantis, Ian Dunn, Zhongyuan Kan, Leland C. Mayne, James Shorter and S. Walter Englander. Hsp104 quaternary structure, nucleotide binding energetics and M-domain dynamics elucidated via HX-MS.
  46. Lim, Jack Wee*, Matthew A. Stetz, Kyle W. Harpole, Vignesh Kasinath and A. Joshua Wand. Application of the entropy meter to protein systems.
  47. Culik, Robert M.*, Thomas Troxler, G. Andrew Woolley and Feng Gai. Using a phototrigger to modulate the folding of the Trp-cage miniprotein.
  48. Nucci, Nathaniel V., Kathleen G. Valentine and A. Joshua Wand*. High-resolution NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids.
  49. Valentine, Kathleen G.*, Guinivere Mathies, Sabrina Bédard, Nathaniel V. Nucci, Matthew A. Stetz, Igor Dodevski, Vignesh Kasinath, Thach Can, Robert Griffin and A. Joshua Wand.  Reverse micelles provide the platform for dynamic nuclear polarization enhancements in solution NMR of proteins.
  50. Harpole, Kyle W.*, Kathleen G. Valentine, Wolfgang Peti and A. Joshua Wand.  Probing the (thermo)dynamics of kinase-inhibitor binding.
  51. Moorman, Veronica R., Kathleen G. Valentine, Jakob Dogan, Sabrina Bédard*, Vignesh Kasinath, Fiona M. Love and A. Joshua Wand. Dynamic response of the RAS protein Cdc42Hs upon association with the binding domain of the effector protein PAK.
  52. Akl, Adam*, George Xu, Ravi Amaravadi and David W. Speicher. Novel molecular markers of intracellular autophagy dynamics in therapy-resistant melanoma.
  53. Nucci, Nathaniel V.*, Igor Dodevski, Kathleen G. Valentine, Gurnimrat Sidhu, Evan S. O’Brien, Evangelia A. Athanasoula, Connie Liao and A. Joshua Wand. A new ‘universal’ surfactant system for encapsulating proteins and RNA in reverse micelles with structural fidelity. 
  54. Nucci, Nathaniel V.*, Kathleen G. Valentine, Veronica R. Moorman, John M. Gledhill, Li Liang, John M. Franck, Adlin Scott, Song-I Han and A. Joshua Wand. The interplay of protein and solvent dynamics: revelations from NMR.
  55. Tariq, Amber*, Meredith E. Jackrel and James Shorter. Engineering Hsp104 to suppress alpha-synuclein toxicity in yeast.
  56. Ford, Alice F.*, Emily A. Scarborough and James Shorter. Mechanisms and modifiers of hnRNPA1 and hnRNPA2 misfolding and toxicity.
  57. Jorge, Christine, Kathleen G. Valentine, Li Liang, Starla Glover, Leif Hammarström and Cecilia Tommos*. There and back again – a radical chemist’s tale.
  58. Zaytsev, Anatoly V.*, Jeanne E. Mick, Boris Nikashin, Eugene Maslennikov, Fazly I. Ataullakhanov, Jennifer G. DeLuca and Ekaterina L. Grishchuk. NDC80 microtubule binding but not cooperativity decreases proportionally to the number of phosphorylated residues in NDC80 tail.
  59. Bagchi, Atrish*, Nicholas J. Bessman, Zhengyi (Neo) Wu, Zhongyuan Kan, S. Walter Englander, Mark A. Lemmon and Kathryn M. Ferguson. Towards understanding the allosteric activation of the Epidermal Growth Factor receptor.
  60. Falk, Samantha J.*, Lucie Y. Guo*, Nikolina Sekulic, Tomoyasu Mani, Sergei A. Vinogradov and Ben E. Black. CENP-C locks the CENP-A nucleosome into a conventionally shaped octameric histone core.
  61. Ennist, Nathan M.*, Goutham Kodali, Tatiana V. Esipova, Sergei A. Vinogradov, Steven E. Stayrook, Christopher C. Moser and P. Leslie Dutton. Design of a 4-helix bundle protein for light-driven charge separation.
  62. Kotaru, Sravya*, Jason O. Moore, Mark A. Lemmon and Kathryn M. Ferguson. Potential regulation of Tie Receptor Tyrosine Kinase family signallng: Tie1-Tie2 hetero-oligomerisation.
  63. Sekulic, Nikolina*, Samantha J. Falk, Kushol Gupta, Sijie Wei, Tomoyasu Mani, Sergei A. Vinogradov, Tae-Hee Lee, Gregory D. Van Duyne and Ben E. Black. Nucleosome structural alterations conferred by CENP-A.
  64. Chen, Helen* and Morris J. Birnbaum. FoxO1 negatively regulates albumin production.
  65. Sims, Carrie A.*, Yuxia Guan, Hao Wang, Lance B. Becker and Joseph A. Baur. Mitochondrial dysfunction in sepsis and hemorrhagic shock.
  66. Smoak, Evan M.*, Jonathon A. Bell, Richard M. Schultz, Ben E. Black and Michael A. Lampson. Transgenerational maintenance of centromere identity.
  67. Sochor, Matthew A.* and Mitchell Lewis. The lac repressor in eukaryotes.
  68. Gajula, Kiran* and Rahul M. Kohli. Identifying functional determinants of the immune mutator enzyme, activation-induced deaminase by high-throughput structure-function analysis.
  69. Gupta, Kushol*, Lydia M. Contreras, Dorie Smith, Tao Huang, Lynn A. Spruce, Steven H. Seeholzer, Marlene Belfort and Gregory D. Van Duyne. Structural properties of an active, native group II intron ribonucleoprotein complex.
  70. Jordan, E. Joseph* and Ravi Radhakrishnan. Classification of kinase domain activating mutations.
  71. Lippert, Lisa G.*, Tali Dadosh, Weihong Qiu, Samara Reck-Peterson and Yale E. Goldman. Orientation changes of the yeast cytoplasmic dynein ring domain observed using four-angle tracking of position and polarization of avidin-functionalized CdSe nanorods.
  72. Tsai, Pei-Fang*, Robert J. Lake, Ju-Yeon Kim, Inchan Choi, Kyoung-Jae Won and Hua-Ying Fan. Bookmark the genome: the role of RBPJ in mitosis.
  73. Ohnishi, Tomoko* and S. Tsuyoshi Ohnishi. Involvement of two distinct protein-associated ubiquinone molecules in the proton-pumping mechanism in complex I (NADH-quinone oxidoreductase).
  74. Ziraldo, Solongo* and E. James Petersson. Development and application of semi-synthetic thioamide containing protein.
  75. Crescenzi, Rachelle*, Catherine M. DeBrosse, Ravi Prakash Nanga, Kevin D’Aquilla, Ari Borthakur, Hari Hariharan, Virginia M.-Y. Lee and Ravinder Reddy.  Glutamate changes in mouse models of tauopathy.
  76. Wu, Zhengyi (Neo)* and Mark A. Lemmon.  EGF receptor-mediated cell signaling network.
  77. DeBrosse, Catherine M.*, Mohammad Haris, Rachelle Crescenzi and Ravinder Reddy. CEST MRI of tumor protease activity.
  78. Marques, Bryan S.*, Nathaniel V. Nucci, Igor Dodevski, Kristina W.C. Wang, Evangelia A. Athanasoula, Christine Jorge and A. Joshua Wand. Measurement and control of pH in the aqueous interior of reverse micelles.
  79. Marques, Bryan S.*, Nathaniel V. Nucci and A. Joshua Wand. Site-resolved measurements of hydration dynamics in hen egg-white lysozyme.
  80. Bédard, Sabrina, Brian Fuglestad* and A. Joshua Wand. Improving fragment-based drug design using the confined space of reverse micelles.
This Retreat is open to the public. Therefore, posters or presentations given at this event are public disclosures and may negatively impact the University of Pennsylvania’s ability to protect the work under intellectual property law. If you feel the work may be of commercial interest or plan to disclose it to Penn’s Center for Technology Transfer in the future, CTT encourages you to disclose it to their office at least one month prior to this event.