Fall 2012 – Spring 2013
All seminars are Fridays at 4:00 p.m.
JF Library, 248 Antatomy-Chemistry Building
Refreshments served at 3:45 p.m.
Molecular switches I • click here to see full listing of past seminars
SEPTEMBER 7
Laboratory of Kristen Lynch | Biochemistry and Biophysics
Signal-induced changes in protein interactions to regulate splicing
Kristen Lynch and Chris Yarosh
SEPTEMBER 14
Laboratory of Ben Black | Biochemistry and Biophysics
Switching on new centromeres and the deviant nucleosomes that do it
Ben Black and Tanya Panchenko
SEPTEMBER 21
Laboratory of Roberto Dominguez | Physiology
Molecular switches of the actin cytoskeleton
Roberto Dominguez and David Kast
SEPTEMBER 28
Laboratory of Ben Garcia | Biochemistry and Biophysics
Quantitative proteomics for understanding the histone code
Ben Garcia and Barry Zee
OCTOBER 5
Laboratory of Kate Ferguson | Physiology
Extracellular control of receptor tyrosine kinases
Kate Ferguson and Jason Moore
OCTOBER 12
Laboratory of Franz Matschinsky | Biochemistry and Biophysics
Diverse tissue specific molecular switching of glucokinase
Franz Matschinsky and Bogumil Zelent
Repairing the glucokinase switch of pancreatic beta-cells in diabetic states
Nicolai Doliba
Membranes • click here to see full listing of past seminars
OCTOBER 19
Laboratory of Bohdana Discher | Biochemistry and Biophysics
The challenges of building bioenergetic membranes
Bohdana Discher and Bryan Fry
OCTOBER 26
Laboratory of Zhe Lu | Physiology
Conformational changes in the ligand-binding domain of ion channels
Zhe Lu, David Lin, and John Lewis
NOVEMBER 9
Laboratory of Michael Ostap | Physiology
How a molecular motor generates force when bound to lipid membranes. A single-molecule approach.
Michael Ostap and Serapion Pyrpassopoulos
NOVEMBER 16
Laboratory of Paul Janmey | Physiology
Polyphosphoinositides
Paul Janmey, David Slochower, and Eric Wang
NOVEMBER 30
Laboratory of Ravi Radhakrishnan | Bioengineering
Modeling membrane remodeling
Ravi Radhakrishnan, Ryan Bradley, Rick Tourdot, and N Ramakrishnan
DECEMBER 7
Laboratory of Tobias Baumgart | Chemistry
Biophysics of lipid and protein interactions and their modulation by membrane curvature
Tobias Baumgart and Benjamin Capraro
DECEMBER 14
Laboratory of Roberto Dominguez | Physiology
At the interface between the actin cytoskeleton and the plasma membrane
Roberto Dominguez and Adam Zwolak
JANUARY 11
Laboratory of Paul Axelsen | Pharmacology
Protein [mis]folding, lipid membranes, and amyloid fibril structure in Alzheimer's disease
Paul Axelsen and Alexandra Klinger
Molecular switches II • click here to see full listing of past seminars
JANUARY 25
Laboratory of Les Dutton | Biochemistry and Biophysics
Imagine all the switches
Les Dutton and Molly Sheehan
FEBRUARY 1 | SPECIAL EDITION | Reunion Hall, John Morgan Building
Paavo K.J. Kinnunen, Ph.D., Professor, Aalto University School of Science
Oxidized phospholipids, from biophysics to implications in clinical oncology
Thomas Heimburg, Ph.D.,Head, Membrane Biophysics Group, Niels Bohr Institute
Physical aspects of nerve pulse propagation, and of general and local anesthesia
FEBRUARY 15
Laboratory of Sergei Vinogradov | Biochemistry and Biophysics
Switching light by spin: coupling optical and magnetic imaging
Sergei Vinogradov and Tomo Mani
FEBRUARY 22
Laboratory of Gideon Dreyfuss | Biochemistry and Biophysics
Telescripting: A major new dimension of gene expression regulation
Lili Wan and Gideon Dreyfuss
Protein folding, assembly and disassembly • click here to see full listing of past seminars
MARCH 1
Laboratory of Walter Englander | Biochemistry and Biophysics
Protein folding and function measured by hydrogen exchange and mass spectrometry
Walter Englander, Evan O'Brien, Leland Mayne, Ben Walters
MARCH 8
Laboratory of Yair Argon | Pathology and Laboratory Medicine
The unfolded protein response
Yair Argon
MARCH 15
Laboratory of Ben Black | Biochemistry and Biophysics
Co-folding of the histone chaperone DAXX and H3.3/H4
Ben Black, Jamie DeNizio
MARCH 22
Laboratory of Mickey Marks | Pathology and Laboratory Medicine
PMEL and melanosome biogenesis: Regulatory checkpoints in the assembly of a functional amyloid
Mickey Marks
MARCH 29
Laboratory of Feng Gai | Chemistry
Can we make the folding energy landscape visible?
Feng Gai, Rob Culik, Chun-Wei Lin
APRIL 12
Laboratories of Kim Sharp and Josh Wand | Biochemistry and Biophysics
Switching on the conformational entropy meter
Kim Sharp, Josh Wand, Vignesh Kasinath
APRIL 19
Laboratory of Roland Dunbrack | Fox Chase Cancer Center
Modeling the structures of biological assemblies
Roland Dunbrack, Maxim Shapovalov
APRIL 26
Laboratory of Jim Shorter | Biochemistry and Biophysics
Plasticity and potentiation of protein disaggregases
Jim Shorter, Morgan DeSantis, Meredith Jackrel
Molecular switches III
APRIL 5
Laboratory of Takaski Yonetani | Biochemistry and Biophysics
Where is the molecular switch for high-and low-affinity states of Hb located? At the heme? No, it is in the globin! Integration of structure (structural allostery), structural dynamics (entropic allostery), thermodynamics, transient kinetics, and MD simulations of Hb
Takashi Yonetani
IN THE SECOND HALF HOUR
Discussion of 2013-2014 FRD led by Kristen Lynch
MAY 3
Laboratory of
Hua-Ying Fan
Hua-Ying Fan, Bob Lake, Erica Boetefuer
Structure, function and regulation of CSB chromatin remodeler: a multi-talented gymnast
MAY 10
Final TGIF / End of the year party
2013 The Trustees of the University of Pennsylvania