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HOME » SEMINARS » FRIDAY RESEARCH DISCUSSIONS

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Fall 2012 – Spring 2013

All seminars are Fridays at 4:00 p.m.
JF Library, 248 Antatomy-Chemistry Building
Refreshments served at 3:45 p.m.

Molecular switches I • click here to see full listing of past seminars

SEPTEMBER 7
Laboratory of Kristen Lynch | Biochemistry and Biophysics
Signal-induced changes in protein interactions to regulate splicing
Kristen Lynch and Chris Yarosh

SEPTEMBER 14
Laboratory of Ben Black | Biochemistry and Biophysics
Switching on new centromeres and the deviant nucleosomes that do it
Ben Black and Tanya Panchenko

SEPTEMBER 21
Laboratory of Roberto Dominguez | Physiology
Molecular switches of the actin cytoskeleton
Roberto Dominguez and David Kast

SEPTEMBER 28
Laboratory of Ben Garcia | Biochemistry and Biophysics
Quantitative proteomics for understanding the histone code
Ben Garcia and Barry Zee

OCTOBER 5
Laboratory of Kate Ferguson | Physiology
Extracellular control of receptor tyrosine kinases
Kate Ferguson and Jason Moore

OCTOBER 12
Laboratory of Franz Matschinsky | Biochemistry and Biophysics
Diverse tissue specific molecular switching of glucokinase
Franz Matschinsky and Bogumil Zelent
Repairing the glucokinase switch of pancreatic beta-cells in diabetic states
Nicolai Doliba

Membranes • click here to see full listing of past seminars

OCTOBER 19
Laboratory of Bohdana Discher | Biochemistry and Biophysics
The challenges of building bioenergetic membranes
Bohdana Discher and Bryan Fry

OCTOBER 26
Laboratory of Zhe Lu | Physiology
Conformational changes in the ligand-binding domain of ion channels
Zhe Lu, David Lin, and John Lewis

NOVEMBER 9
Laboratory of Michael Ostap | Physiology
How a molecular motor generates force when bound to lipid membranes. A single-molecule approach.
Michael Ostap and Serapion Pyrpassopoulos

NOVEMBER 16
Laboratory of Paul Janmey | Physiology
Polyphosphoinositides
Paul Janmey, David Slochower, and Eric Wang

NOVEMBER 30
Laboratory of Ravi Radhakrishnan | Bioengineering
Modeling membrane remodeling
Ravi Radhakrishnan, Ryan Bradley, Rick Tourdot, and N Ramakrishnan

DECEMBER 7
Laboratory of Tobias Baumgart | Chemistry
Biophysics of lipid and protein interactions and their modulation by membrane curvature
Tobias Baumgart and Benjamin Capraro

DECEMBER 14
Laboratory of Roberto Dominguez | Physiology
At the interface between the actin cytoskeleton and the plasma membrane
Roberto Dominguez and Adam Zwolak

JANUARY 11
Laboratory of Paul Axelsen | Pharmacology
Protein [mis]folding, lipid membranes, and amyloid fibril structure in Alzheimer's disease
Paul Axelsen and Alexandra Klinger

Molecular switches II • click here to see full listing of past seminars

JANUARY 25
Laboratory of Les Dutton | Biochemistry and Biophysics
Imagine all the switches
Les Dutton and Molly Sheehan

FEBRUARY 1 | SPECIAL EDITION | Reunion Hall, John Morgan Building
Paavo K.J. Kinnunen, Ph.D., Professor, Aalto University School of Science
Oxidized phospholipids, from biophysics to implications in clinical oncology
Thomas Heimburg, Ph.D.,Head, Membrane Biophysics Group, Niels Bohr Institute
Physical aspects of nerve pulse propagation, and of general and local anesthesia

FEBRUARY 15
Laboratory of Sergei Vinogradov | Biochemistry and Biophysics
Switching light by spin: coupling optical and magnetic imaging
Sergei Vinogradov and Tomo Mani

FEBRUARY 22
Laboratory of Gideon Dreyfuss | Biochemistry and Biophysics
Telescripting: A major new dimension of gene expression regulation
Lili Wan and Gideon Dreyfuss

Protein folding, assembly and disassembly • click here to see full listing of past seminars

MARCH 1
Laboratory of Walter Englander | Biochemistry and Biophysics
Protein folding and function measured by hydrogen exchange and mass spectrometry
Walter Englander, Evan O'Brien, Leland Mayne, Ben Walters

MARCH 8
Laboratory of Yair Argon | Pathology and Laboratory Medicine
The unfolded protein response
Yair Argon

MARCH 15
Laboratory of Ben Black | Biochemistry and Biophysics
Co-folding of the histone chaperone DAXX and H3.3/H4
Ben Black, Jamie DeNizio

MARCH 22
Laboratory of Mickey Marks | Pathology and Laboratory Medicine
PMEL and melanosome biogenesis: Regulatory checkpoints in the assembly of a functional amyloid
Mickey Marks

MARCH 29
Laboratory of Feng Gai | Chemistry
Can we make the folding energy landscape visible?
Feng Gai, Rob Culik, Chun-Wei Lin

APRIL 12
Laboratories of Kim Sharp and Josh Wand | Biochemistry and Biophysics
Switching on the conformational entropy meter
Kim Sharp, Josh Wand, Vignesh Kasinath

APRIL 19
Laboratory of Roland Dunbrack | Fox Chase Cancer Center
Modeling the structures of biological assemblies
Roland Dunbrack, Maxim Shapovalov

APRIL 26
Laboratory of Jim Shorter | Biochemistry and Biophysics
Plasticity and potentiation of protein disaggregases
Jim Shorter, Morgan DeSantis, Meredith Jackrel

Molecular switches III

APRIL 5
Laboratory of Takaski Yonetani | Biochemistry and Biophysics
Where is the molecular switch for high-and low-affinity states of Hb located? At the heme? No, it is in the globin! Integration of structure (structural allostery), structural dynamics (entropic allostery), thermodynamics, transient kinetics, and MD simulations of Hb
Takashi Yonetani

IN THE SECOND HALF HOUR

Discussion of 2013-2014 FRD led by Kristen Lynch

MAY 3
Laboratory of Hua-Ying Fan
Hua-Ying Fan, Bob Lake, Erica Boetefuer
Structure, function and regulation of CSB chromatin remodeler: a multi-talented gymnast

MAY 10
Final TGIF / End of the year party

2013 The Trustees of the University of Pennsylvania