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Spring 2015

All seminars are Fridays at 4:00 p.m.
JF Library, 248 Antatomy-Chemistry Building
Refreshments served at 3:45 p.m.

DISEASES AND THERAPY

APRIL 17
Mitch Lazar and Jarrett Remsberg
Laboratory of Mitch Lazar | Department of Medicine
All HDACs are not created equal: Studies on the biochemistry and physiology of histone deacetylase 3

APRIL 24
Zhe Lu, Valentina Dimitrova, and Yajamana Ramu
Laboratory of Zhe Lu | Department of Physiology
Developing strategies for treating channelopathies

MAY 1
Andrew Tsourkas and Beth Higbee
Laboratory of Andrew Tsourkas | Department of Bioengineering
Engineering nanoparticles for imaging and therapeutic applications

David Speicher and Adam Kraya
Laboratory of David Speicher | The Wistar Institute
Probing the role of autophagy in melanoma progression and therapy

MAY 8
Mike Lampson and Evan Smoak
Laboratory of Mike Lampson | Department of Biology
Transgenerational inheritance of centromere identity in the mammalian germline

Mike Ostap and Michael Woody
Laboratory of Mike Ostap | Department of Physiology
Cardiac myosin: Correlating mechanical forces and biochemical kinetics

MAY 15
Jim Shorter, Korrie Mack, and Alice Ford
Laboratory of Jim Shorter | Department of Biochemistry & Biophysics
Mechanisms to counter proteotoxicity

MAY 22
End of year party

Past Topics and Seminars, Fall and Winter 2014-2015 - CLICK TITLE FOR COMPLETE LISTING

PROTEIN COMPLEXES AND THEIR FUNCTION

SEPTEMBER 19
Eric Babiash, Anna Maria Pinto
Laboratory of Gideon Dreyfuss | Biochemistry & Biophysics
Function and biogenesis of U1 snRNP: an overarching mRNA regulator

SEPTEMBER 26
Scott Ugras
Laboratory of Harry Ischiropoulos | Pediatrics
Alpha synuclein aggregation perturbs phosphorylation signaling

OCTOBER 3
Cory Rice
Laboratory of Emmanuel Skordalakes | Gene Expression and Regulation Program, Wistar Institute
CST dependent telomere length regulation

OCTOBER 10
Alec Ricciuti, Wenbing Hu
Laboratory of Walter Englander | Biochemistry & Biophysics
Protein interactions studied by HX MS (hydrogen exchange and mass spectrometry)

OCTOBER 17
Matt Stetz, Kyle Harpole
Laboratory of Josh Wand | Biochemistry & Biophysics
Proteins, conformational entropy and the magical complexity of allostery

OCTOBER 24
Robert Magin, Allison Haigney
Laboratory of Ronen Marmorstein | Biochemistry & Biophysics
Protein complexes and their function in protein acetylation

OCTOBER 31
Glennis Logsdon, Samantha Falk
Laboratory of Ben Black | Biochemistry & Biophysics
The CENP-A nucleosome, the proteins that bind to it, and the mechanisms of centromere establishment and maintenance

MODELING

NOVEMBER 7
David Speicher, Roland Rivera-Santiago
Laboratory of David Speicher | The Wistar Institute
Structural mass spectrometry using zero-length crosslinks

DECEMBER 5
Ravi Radhakrihnan (intro), Joe Jordan, Ryan Bradley , RIchard Tourdot
Laboratory of Ravi Radhakrishnan | Bioengineering
Minimal models across multiple scales – from proteins to cells – mechanisms, constraints, and predictive power

DECEMBER 12
Les Dutton (intro), Nate Ennist, Chris Bialas
Laboratory of Les Dutton | Biochemistry and Biophysics
Modeling solar-activated charge-separation in bird navigation and photosynthesis

JANUARY 9
Kim Sharp, Evan O'Brien
Laboratory of Kim Sharp | Biochemistry & Biophysics
Why we are obsessed with entropy: The origin of high affinity protein-ligand binding

JANUARY 16
Alison Sweeney, James Townsend, Tom Dodson
Laboratory of Alison Sweeney | Physics & Astronomy
Multi-scale molecular modeling: generating physical insights when experiments are hard or impossible

JANUARY 23
Paul Axelsen, Gözde Eskici
Laboratory of Paul Axelsen | Systems Pharmacology & Translational Therapeutics
Is the amyloid fibril good, bad, or just ugly?

JANUARY 30
Les Dutton, Josh Mancini, Zhenyu Zhao, Bryan Fry
Laboratory of Les Dutton | Biochemistry & Biophysics
Sunshine to Moonshine: manmade proteins for solar fuel

GENE REGULATION

FEBRUARY 13
Mark Goulian, Jeffrey Carey, and Srujana Samhita Yadavalli
Laboratory of Mark Goulian | Department of Biology
Two twists on two-component signaling

FEBRUARY 20
Ken Zaret and Meilin Fernandez
Laboratory of Ken Zaret | Department of Genetics
Mechanisms of transcription factor interactions with chromatin
Ronen Marmorstein and Dan Ricketts
Laboratory of Ronen Marmorstein | Department of Biochemistry & Biophysics
Role of ubinuclein-1 in histone H3.3-specific deposition by the HIRA histone chaperone complex

MARCH 6
Rahul Kohli, Emily Schutsky, and Monica Liu
Laboratory of Rahul Kohli | Department of Medicine
Cytosine modifying enzymes and the extended epigenome

MARCH 13
Kristen Lynch, Chris Yarosh, and Sandya Ajith
Laboratory of Kristen Lynch | Department of Biochemistry & Biophysics
Making RNA do what you want: regulation of alternative splicing

MARCH 20
Ben Garcia, Sam Wein, and Kelly Karch
Laboratory of Ben Garcia | Department of Biochemistry & Biophysics
Spectrometry for the masses: focus on epigenetics

MARCH 27
Brad Johnson, Sophie Song, and Becky Billmire
Laboratory of Brad Johnson | Department of Pathology & Lab Medicine
Replication- and transcription-dependent mechanisms that impact cell senescence

APRIL 3
Roberto Dominguez and Bengi Turegun
Laboratory of Roberto Dominguez | Department of Physiology
Actin-related proteins in the nucleus and their role in chromatin remodeling

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