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The Blair Lab Members

Ian A. Blair, Ph.D.

Blair  

Ian Blair, Ph.D. Research in the Blair laboratory is heavily involved in the use of mass spectrometry for proteomics and DNA analysis.

Oxidative stress, carcinogenesis, and cardiovascular disease

The reactive oxygen species superoxide, peroxide, and hydroxyl radical, are generated constantly in vivo from ground state triplet oxygen. This occurs by a variety of endogenous processes including, normal mitochondrial aerobic respiration, phagocytosis of bacteria or virus-containing cells, and peroxisomal-mediated degradation of fatty acids. Catechols, which arise in vivo through the metabolism of drugs, environmental chemicals, and endogenous hormones, generate reactive oxygen species through redox cycling.

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Clementina Mesaros, Ph.D.

Mesaros  

Clementina Mesaros joined the Blair lab in September 2004. She received her Ph. D. in organic chemistry from CASE University, Cleveland. Her graduate research in Prof. Robert Salomon's lab, involved the total synthesis of several oxidized phosphoplipids and mechanistic studies of lipids oxidation. During her three years of post-doctoral training in the Blair lab, she worked on the synthesis of reactive bifunctional electrophiles derived from AA. Clementina was also involved in identification of a novel 4-oxo-2(E)-nonenal adduct with glutathione (TOG) as a biomarker of oxidative stress using LC/MS approaches. She developed an LC/MS method for quantification of epoxy-eicosatrienoic acids and dihyrdroxy eicosatrienoic acids in biological samples. Clementina is now a Senior Investigator in the Blair lab and she is working on developing LC/MS assays for urinary biomarkers of oxidative stress.

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Lili Guo, Ph.D.

 

Lili Guo joined the Blair lab in February, 2014. She received her Ph.D. in cell and molecular biology from the University of Pennsylvania in 2013. Under the supervision of Dr. Xiaolu Yang, her Ph.D. research focused on protein post-translational modifications (PTMs) and their roles in regulating misfolded proteins in neurodegenerative diseases. In the Blair Lab, Lili utilizes LS/MS/MS approaches to study the mechanistic effects of anti-cancer drugs on metabolic pathways, PTMs, and cellular bioenergetics with the aim of improving existing therapies and elucidating new therapeutic targets.  She is also involved in developing and improving LC/MS approaches to quantify protein biomarkers for several diseases.

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Nate Snyder, Ph.D.

 

Nathaniel W. Snyder graduated with honors from University of Maryland: College Park in 2009 with a B.S. in Biochemistry.  He received his Ph.D. in 2013 under the mentorship of Dr. Blair, and will complete a M.P.H. in 2014.  He previously held internships at the USDA in Beltsville, MD, the Genetic Alliance in Washington, D.C. as well as two training awards at NIH: NIAID in Bethesda, MD.  His thesis focused on endogenous lipid mediators of inflammation and cell proliferation.  Ongoing projects include using stable isotopes for quantitative and qualitative measurements of a wide range of biological molecules including acyl-CoAs, poly-unsaturated fatty acids, complex lipids, acyl-carnitines, organic acids, and amino acids.

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Qingqing Wang, Ph.D.

  Qingqing Wang joined the Blair lab in September 2013 as a visiting associate professor. She received her Ph.D. in pharmaceutical analysis from Beijing Institute of Pharmacology in China. Her Ph.D. research focused on quantification and drug-drug interaction of acetylcholinesterase (AChE) inhibitors. She then joined the pharmacology and toxicology lab in the Beijing Institute of Radiation Medicine. There she developed and tested LC/MS and ELISA based methods for quantitative and qualitative determinations of peptides, antisense oligonucleotides, siRNA, amino acids and small molecular drugs in complex biological fluids. Qingqing is currently working on developing pre-ionized derivative based stable isotope dilution methods for quantification of estrogens and androgens. She is also involved in developing LC/MS approaches for non-invasive serum biomarkers of oxidative stress

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Suhong Zhang, Ph.D.

 

Suhong Zhang joined the Blair Lab in July, 2009. He received his Ph.D. (Organic Chemistry) from University of New Orleans in 2006. His dissertation was focused on the Synthesis of Natural Compounds and DAT ligands. He then joined Dr. Dutta's lab as a postdoctoral fellow synthesizing dopamine D3 ligands at Wayne State University. He worked on pain-targeted drug development approximately for one year at Adolor Corporation, before he joined the Blair lab as a postdoctoral research fellow. His current research is the structural identification and quantitative analysis of DNA-adduct in biological fluids using LC/MS/MS system. Suhong is now a Research Associate in the Blair Lab and is studying covalent modifications to DNA by PAH quinines and 8-oxo-2'-deoxyguanosine levels produced due to oxidative DNA damage.

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Lisa Bottalico

  Lisa Bottalico joined the Blair Lab in October 2012. She is a doctoral candidate in the Pharmacology Graduate Group and a student in the Certificate Program in Environmental Health Sciences. Lisa graduated with honors from La Salle University (Philadelphia, PA) in 2005 with a B.A. in Biology and English. She subsequently held a three year internship at the US Army Medical Research Center for Chemical Defense (APG, MD). In the Blair Lab, Lisa will work to develop a breast cancer risk model based on estrogen metabolomics.

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Andrew Worth

 

Andrew joined the Blair lab in the summer of 2012 as a doctoral candidate in the Pharmacology Graduate Group .  He graduated from Gordon College in 2011 with a B.S. in chemistry and a minor in mathematics.  He previously held an internship at Novartis Institute for Biomedical Research.  His research will focus on determining the metabolic links between pesticide exposure, mitochondrial dysfunction, and subsequent neurodegeneration.

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