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Recent Publications

2009

  • Blair, I.A. (2009) Analysis of endogenous glutathione-adducts and their metabolites. Biomed Chromatogr In press; DOI 10.1002/bmc 1374 .
  • Middleton MK, Zukas AM, Rubinstein T, Kinder M, Wilson EH, Zhu P, Blair IA, Hunter CA, Puré E. (2009) 12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis. Infect Immun. 77(12):5690-5700 .
  • Rangiah K, Tippornwong M, Sangar V, Austin D, Tétreault M-P, Rustgi AK., Blair IA, Yu KH. (2009) Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer.  J. Proteome Res. 8(11):5153-64
  • Park JH, Mangal D, Frey AJ, Harvey RG, Blair IA, Penning TM. (2009) The aryl-hydrocarbon receptor (AhR) facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. J Biol Chem. J Biol Chem. 2009 284(43):29725-34 .
  • Lee SH, Blair IA. Targeted chiral lipidomics analysis of bioactive eicosanoid lipids in cellular systems. BMB Rep 42(7):401-410.
  • Zhu P, Jian W, Blair IA. (2009) A 4-oxo-2(e)-nonenal-derived glutathione-adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid. Free Rad Bio Med 47(7):953-61.
  • Wei C, Zhu P, Shah SJ, Blair IA. (2009) 15-Oxo-eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Mol Pharmacol 76(3):516-25. PMC2730384 [Available on 2010/09/01]
  • Weibel GL, Joshi MR, Wei C, Bates SR, Blair IA, Rothblat GH. 15(S)-lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism. J Lipid Res. 50, 2371–2376.
  • Mitchell LE, Morales M, Khartulyari S, Huang Y, Murphy K, Mei M, Von Feldt JM, Blair IA, Whitehead AS. Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data. Clin Biochem. 42(12):1275-81
  • Jian W, Lee SH, Williams MV, Blair IA. (2009) 5-Lipoxygenase-mediated Endogenous DNA Damage. J Biol Chem 284(25):16799-807.
  • Hahn CG, Banerjee A, Macdonald ML, Cho DS, Kamins J, Nie Z, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA. (2009) The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. PLoS ONE 4(4):e5251  PMC2666803
  • Ciccimaro E., Hanks S. K., Yu K. H., and Blair I. A. (2009) Absolute Quantification of Phosphorylation on the Kinase Activation Loop of Cellular Focal Adhesion Kinase by Stable Isotope Dilution Liquid Chromatography/Mass Spectrometry. Anal Chem 81(9):3304-3313. PMC2706532 [Available on 2010/05/01]
  • Weibel GL, Joshi MR, Alexander ET, Zhu P, Blair IA, Rothblat GH. (2009) Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arterioscler Thromb Vasc Biol. 29(6):837-42. PMC 2759530
  • Mesaros, C., Lee, S. H., Blair, I. A. (2009) Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 877(26):2736-45. PMC2745066 [Available on 2010/09/15].
  • Mangal D, Vudathala D, Park JH, Lee SH, Penning TM, Blair IA. (2009) Analysis of 7,8-Dihydro-8-oxo-2'-deoxy guanosine in Cellular DNA during Oxidative Stress. Chem Res Toxicol. 22(5):788-797. PMC2684441
  • Shah SJ, Yu KH, Sangar V, Parry SI, Blair IA. (2009) Identification and Quantification of Preterm Birth Biomarkers in Human Cervicovaginal Fluid by Liquid Chromatography/Tandem Mass Spectrometry. J Proteome Res.. 8(5):2407-2417. PMC2729452
  • Jin Y., Duan L., Lee S.H., Kloosterboer J., Blai I.A., and Penning T.M. (2009) Human cytosolic hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily catalyze reduction of conjugated steroids: implications for phase i and phase iii steroid hormone metabolism J Biol Chem 284(15):10013-10022. PMC2665056 (Avail. 0n 2010/04/10)
  • Matthews R.P., Lorent K., Mañoral-Mobias R., Huang Y., Gong W., Murray I.V.J., Blair I.A., and Pack M. (2009) TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase Development 136, 865-875.
  • Xu D, Penning TM, Blair IA, Harvey RG. (2009) Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer. J Org Chem. 16;74(2):597-604.
  • Yu, KH, Barry CG, Austin D, Busch C.M, Sangar V, Rustgi A.K, Blair I.A. Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery. J Proteome Res 8(3):1565-1576. PMC2652408
  • Ciccimaro E, Hanks SK, Blair IA. (2009) Quantification of Focal Adhesion Kinase Activation Loop Phosphorylation as a Biomarker of Src Activity. Mol Pharmacol. 75(3):658-66. PMC2684915 [Available on 2010/03/01]
  • Lu Z.-Y, Jensen LE, Huang Y, Kealey C, Blair IA, Whitehead A.S. (2009) The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells maintained under long-term low folate stress is mediated by the p38 MAPK pathway. Atherosclerosis 205(1):48-54. PMC2715998
  • Yang, I.-Y. Hashimoto K., de Wind N., Blair I.A., and Moriya M. (2009) Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells. J Biol Chem. 284(1):191-8. PMC2610493 [Available 2010/01/02]

2008

  • Lu Z.-Y., Morales M., Khartulyari S., Mei M., Murphy K.M., Stanislawska-Sachadyn A., Summers, C.M., Huang, Y. Von Feldt, J.M., Blair I.A., Mitchell L.E., Whitehead A.S. (2008) Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. Birth Defects Res A Clin Mol Teratol. 82(10):736-741.
  • Huang Y., Khartulyari S., Morales M.E., Stanislawska-Sachadyn A., Von Feldt J.M., Whitehead A.S., Blair I.A. (2008) Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 22(16):2403-12.
  • Blair, IA. (2008) DNA-adducts with lipid peroxidation products. J Biol Chem. 283(23):15545-9. PMC 2414303.
  • Park J.H., Gelhaus S., Vedantam S., Oliva A.L., Batra A., Blair I.A., Troxel A. B., Field J., Penning T.M. (2008) The Pattern of p53 Mutations Caused by PAH o-Quinones is Driven by 8-oxo-dGuo Formation while the Spectrum of Mutations is Determined by Biological Selection for Dominance. Chem Res Toxicol, 21(5), 1039–1049. PMCID: PMC2671329.
  • Park J.H., Mangal D., Tacka K.A., Quinn A.M., Harvey R.G., Blair I.A., Penning T.M. (2008) Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proc Natl Acad Sci USA 105(19):6846-51. PMC2383938
  • Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, Fitzgerald GA, Grosser T. (2008) Analysis of the zebrafish proteome during embryonic development. Mol Cell Proteomics. 7(5):981-94. PMC2401336
  • Xu D, Duan Y, Blair IA, Penning TM, and Harvey RG. (2008) Synthesis of Dibenzo[def,p]chrysene, Its Active Metabolites, and Their 13C-Labeled Analogues. Org Lett 10(6):1059-1062
  • Shultz CA, Palackal NT, Mangal D, Harvey RG, Blair IA, Penning TM. (2008) Fjord-region Benzo[g]chrysene-11,12-dihydrodiol and Benzo[c]phenanthrene-3,4-dihydrodiol as Substrates for Rat Liver Dihydrodiol Dehydrogenase (AKR1C9): Structural Basis for Stereochemical Preference. Chem Res Toxicol. 21(3):668-677 PMC2440589
  • Ran C, Dai Q, Ruan Q, Penning TM, Blair IA, Harvey RG. (2008) Strategies for Synthesis of Adducts of o-Quinone Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons with 2'-Deoxyribonucleosides J. Org. Chem., 73 (3), 992 -1003.
  • Zhu P, Oe T, and Blair IA. (2008) Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide. Rapid Commun Mass Spectrom. 22: 432-440.

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