Blair Lab Home » Publications

Recent Publications

  • 2014
  • Worth AJ, Basu SS, Snyder NW, Mesaros C, Blair IA (2014) Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation supporting acetyl-coenzyme A levels. J Biol Chem [ 2014 Aug 12 Epub ahead of print] pii: jbc.M114. 591354
  • Snyder NW, Basu SS, Zhou Z, Worth AJ, and Blair IA. (2014) Stable isotope dilution liquid chromatography-mass spectrometry analysis of cellular and tissue medium- and ongchain acyl-coenzyme A thioesters. Rapid Commun Mass Spectrom 28, 1840–1848. NIHMSID606812
  • Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm BirthResearch. (2014) Maternal serum serpin B7 is associated with early spontaneous preterm birth. Am J Obstet Gynecol. 2014 Jun 19. pii: S0002-9378(14)00608-5. doi: 10.1016/j.ajog.2014.06.035. [Epub ahead of print]
  • Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation (2014) Cell Metab. 2014 Jul 2. pii: S1550-4131(14)00269-1. doi: 10.1016/j.cmet.2014.06.004
  • Huang M, Zhang L, Mesaros C, Zhang S, Blaha MA, Blair IA, Penning TM. (2014) Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells. (2014) Chem Res Toxicol 27(5):852-63. PMCID: PMC4028327
  • Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA. (2014) The aspartate metabolism pathway is differentiable in human hepatocellular carcinoma: transcriptomics and 13 C-isotope based metabolomics. NMR Biomed. 27(4):381-9. PMCID: PMC3962779 [Available on 2015/4/1]
  • Summers CM, Hammons AL, Arora J, Zhang S, Jochems J, Blair IA, Whitehead AS. Methotrexate modulates folate phenotype and inflammatory profile in EA.hy926 cells. Eur J Pharmacol. 732:60-7. (NIHMS580704)
  • 2013

  • Basu SS, Deutsch EC, Schmaier AA, Lynch DR, Blair IA. (2013) Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS. 5(24):3009-21. PMCID: PMC3912754 [Available on 2014/10/1]
  • Baldwin DA, Sarnowski CP, Reddy SA, Blair IA, Clapper M, Lazarus P, Li M, Muscat JE, Penning TM, Vachani A, Whitehead AS. (2013) Development of a genotyping microarray for studying the role of gene-environment interactions in risk for lung cancer. J Biomol Tech. 2013 Dec;24(4):198-217. PMCID:PMC3792704
  • Zhang L, Huang M, Blair IA, Penning TM. (2013) Interception of Benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGT) in Human Lung Cells. Chem Res Toxicol. 26(10):1570-8. PMCID: PMC3829198
  • Snyder NW, Revello SD, Liu X, Zhang S, Blair IA (2013) Cellular uptake and anti-proliferative effects of 11-oxo-eicosatetraenoic acid. J Lipid Res. 54(11):3070-7. PMCID: PMC3793611.
  • Tamae D, Byrns M, Marck B, Mostaghel EA, Nelson PS, Lange P, Lin D, Taplin ME, Balk S, Ellis W, True L, Vessella R, Montgomery B, Blair IA, Penning TM. (2013) Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum. J Steroid Biochem Mol Biol. 138C: 281-289. PMCID: PMC3866616 [Available on 2014/11/1]
  • Huang M, Blair IA, Penning TM. (2013) Identification of stable benzo[a]pyrene-7,8-dione-DNA adducts in human lung cells. Chem Res Toxicol. 26(5):685-92 PMCID: PMC3660951.
  • Lee I, Dodia C, Chatterjee S, Zagorski J, Mesaros C, Blair IA, Feinstein SI, Jain M, Fisher AB. (2013) A novel non-toxic inhibitor of the activation of NADPH oxidase (NOX2) reduces reactive oxygen species production in mouse lung. J Pharmacol Exp Ther. 345(2):284-96. PMCID: PMC3629794 [Available on 2014/5/1]
  • Strasser AA, Ashare RL, Kaufman M, Tang KZ, Mesaros C, Blair IA. The effect of menthol on cigarette smoking behaviors, biomarkers and subjective responses. Cancer Epidemiol Biomarkers Prev. 2013 Jan 18. [Epub ahead of print] PMCID: PMC3596436 [Available on 2014/3/1]
  • 2012

    Snyder N, Khezam M, Mesaros AC, Worth A, and Blair IA. Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography- High Resolution Mass Spectrometry (UPLC-HRMS). J Vis Exp. 2012 Dec 20. In Press.
  • Hood ED, Greineder CF, Dodia C, Han J, Mesaros C, Shuvaev VV, Blair IA, Fisher AB, Muzykantov VR. (2012) Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo  J Control Release 163(2):161-9. PMCID:PMC3495982 [Available on 2013/10/28]
  • Hammons AL, Summers CM, Jochems J, Arora JS, Zhang S, Blair IA, Whitehead AS. (2012) Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions Eur J Pharmacol. 696(1-3):12-17
  • MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG. (2012) Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry for Targeted and Microdomain-Specific Protein Quantification in Human Postmortem Brain Tissue. Mol Cell Proteomics 11(12):1670-81. PMCID:PMC3518127 [Available on 2013/12/1]
  • Zhang L, Huang M, Blair IA, Penning TM (2012) Detoxication of Benzo[a]pyrene-7,8-dione by Sulfotransferases (SULT) in Human Lung Cells. J Biol Chem. 287(35):29909-20. PMCID: PMC3436139 [Available on 2013/8/24]
  • Ashare RL, Tang KZ, Mesaros AC, Blair IA, Leone FT, Strasser AA. (2012) Effects of 21 days of varenicline versus placebo on smoking behaviors and urges among non-treatment seeking smokers. J Psychopharmacol. (10):1383-90. PMCID: PMC3526838
  • Mesaros C, Arora JS, Wholer A, Vachani A, Blair IA (2012) 8-Oxo-2'-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress. Free Radic Biol Med. 53(3):610-7. (NIHMSID#379825)
  • Huang M, Liu X, Basu SS, Zhang L, Kushman ME, Harvey RG, Blair IA, Penning TM. (2012) Metabolism and Distribution of Benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in Human Lung Cells by Liquid Chromatography Tandem Mass Spectrometry: Detection of an Adenine B[a]P-7,8-dione Adduct. Chem Res Toxicol. 25(5):993-1003. PMCID PMC3358497 [Available on 2013/5/21]
  • Mesaros C., Blair I.A. (2012) Targeted Chiral Analysis of Bioactive Arachidonic Acid Metabolites Using Liquid-Chromatography-Mass Spectrometry. Metabolites 2(2):337-365 (open access journal)
  • Wehr AY, Hwang W-T, Blair IA, Yu KH. (2012) Relative Quantification of Serum Proteins from Pancreatic Ductal Adenocarcinoma Patients by Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry. J Proteome Res. 11(3) 1749-1758. PMCID: PMC3292696
  • Gelhaus SL, Gilad O, Hwang W-T, Penning TM, Blair IA. (2012)  Multidrug Resistance Protein (MRP) 4 Attenuates Benzo[a]Pyrene-Mediated DNA-adduct Formation in Human Bronchoalveolar H358 Cells. Toxicol Lett 209(1):58-66. PMCID: PMC3256298
  • Basu SS and Blair IA. (2012) Labeling by Essential Nutrients in Cell Culture (SILEC): a protocol to generate and utilize isotopically labeled coenzyme A standards. Nature Protocols 7(1):1-11. PMCID Journal in Progress
  • 2011

  • Gelhaus SL, Mesaros AC, and Blair IA. (2011) Cellular lipid extraction for targeted stable isotope dilution liquid chromatography-mass spectrometry analysis. J. Vis. Exp. (57), e3399, DOI: 10.3791/3399
  • Speed, N. K. and Blair, I.A. (2011) Cyclooxygenase- and lipoxygenase-mediated DNA damage. Cancer Metastasis Rev. 30:437-447. PMCID: PMC3237763.
  • Lu D, Harvey RG, Blair IA, Penning TM. (2011) Quantitation of Benzo[a]pyrene Metabolic Profiles in Human Bronchoalveolar (H358) Cells by Stable Isotope Dilution Liquid Chromatography-Atmospheric Chemical Ionization Mass Spectrometry. Chem Res Toxicol. 24(11):1905-14. PMCID Journal in Progress
  • Basu SS anf Blair IA. (2011) Rotenone-Mediated Changes in Intracellular Coenzyme A Thioester Levels: Implications for Mitochondrial Dysfunction. Chem. Res. Toxicol. 24(10):1630-2. PMCID: PMC3196242
  • Liu X, Zhang S, Arora JS, Snyder NW, Shah SJ, and Blair IA. (2011) 11-Oxo-Eicosatetraenoic Acid is a Cyclooxygenase-2/15-Hydroxyprostaglandin Dehydrogenase-Derived Anti-Proliferative Eicosanoid. Chem Res Toxicol 24(12):2227-36. PMCID: PMC3242474
  • Zhang L, Jin Y, Chen M, Huang M, Harvey RG, Blair IA, Penning TM (2011)  Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyl transferases (COMT) via O-methylation of PAH catechols  J Biol Chem. 286(29):25644-54. PMCID: PMC3138279
  • DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475(7354):106–109. PMCID: PMC340447
  • Jin Y, Mesaros CA, Blair IA, Penning TM.  Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the aldo-keto reductase (AKR) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway. Biochem J 437(1):53-61
  • Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, Blair IA, Potter DA.  (2011) CYP3A4 mediates growth of ER+ breast cancer cells, in part, by nuclear translocation of phospho-Stat3 through biosynthesis of ({+/-})-14,15-EET. Biol Chem. 2286(20):17543-59. PMCID: PMC3093829
  • Wehr AY, Furth EE, Sangar V, Blair IA, Yu KH. (2011) Analysis of the Human Pancreatic Stellate Cell Secreted Proteome. Pancreas 40(4):557-66. PMCID: PMC3086313.
  • Mitra R, Lee J, Jo J, Milani M, McClintick JN, Edenberg HJ, Kesler KA, Rieger KM, Badve S, Cummings OW, Mohiuddin A, Thomas DG, Luo X, Juliar BE, Li L, Mesaros C, Blair IA, Srirangam A, Kratzke R, McDonald CJ, Kim J, Potter DA. (2011) Prediction of Postoperative Recurrence-Free Survival in Non-small Cell Lung Cancer by Using an Internationally Validated Gene Expression Model. Clin Cancer Res. 17(9):2934-2946. PMCID: PMC3086939
  • Rangiah K, Sumit, S, Vachani A, Ciccimaro E, Blair IA. (2011) Liquid chromatography/mass spectrometry of pre‐ionized Liquid chromatography/mass spectrometry of pre‐ionized in serum from postmenopausal women. Rapid Commun. Mass Spectrom 25(9):1297-307.
  • Rangiah K, Hwang WT, Mesaros AC, Vachani A, and Blair IA. (2011) Nicotine exposure and metabolizer phenotypes from analysis of urinary nicotine and its fifteen metabolites by liquid chromatography-mass spectrometry.  Bioanalysis 3(7):745-61. PMCID: PMC3134267
  • Arora JS, Oe T, Blair IA. (2011) Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(E)-nonenal. J. Label Compd. Radiopharm 2011, 54 247–251
  • Basu, S. S.; Mesaros, C.; Gelhaus, S. L.; Blair, I. A. (2011) Stable Isotope Labeling by Essential Nutrients in Cell Culture (SILEC) for the Preparation of Labeled Coenzyme A Thioesters. Anal Chem 83(4):1363-9. PMCID: PMC3048769
  • Bhat SH, Gelhaus SL, Mesaros AC, Vachani A, Blair IA. (2011) A new liquid chromatography/ mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine. Rapid Commun Mass Spectrom 25, 115–121. PMCID: PMC3348551
  • Johnson TV, Gupta PK, Vudathala DK, Blair IA, Tanna AP. (2011) Thermal stability of bimatoprost, latanoprost, and travoprost under simulated daily use. J Ocul Pharmacol Ther. 27(1):51-9. PMCID: PMC3038126.
  • Fong KP, Barry C, Tran AN, Traxler EA, Wannemacher KM, Tang HY, Speicher KD, Blair IA, Speicher DW, Grosser T, Brass LF. (2011) Deciphering the human platelet sheddome. Blood. 117(1):e15-26. PMCID: PMC3037762
  • Gelhaus SL, Harvey RG, Penning TM and Blair IA. (2011) Regulation of Benzo[a]pyrene-Mediated DNA-and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells. Chem Res Toxicol. 24(1):89-98. PMCID: PMC3021323.
  • 2010

  • Mesaros C, Lee SH, Blair IA. (2010) Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography /electron capture atmospheric pressure chemical ionization mass spectrometry using [(13)C]-analog internal standards. Rapid Commun. Mass Spectrom 24(22):3237-47. PMCID: PMC3348553

  • Kinder M, Thompson JE, Wei C, Shelat SG, Blair IA, Carroll M, Puré E. Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling. Exp Hematol 38(11):1036-1046.e1-4. PMCID: PMC2963586
  • Summers C. M., Mitchell L.E., Stanislawska-Sachadyn A., Baido S.F., Blair I.A., Von Feldt J.M., Whitehead A.S. (2010) Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. Birth Defects Res A Clin Mol Teratol 88(8):679-88
  • Cooper PR, Mesaros AC, Zhang J, Christmas P, Stark CM, Douaidy K, Mittelman MA, Soberman RJ, Blair IA, Panettieri, Jr. RA. (2010) 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PLoS ONE 5(4):e10235. PMCID: PMC2857875
  • Kinder M, Wei C, Shelat SG, Kundu M, Zhao L, Blair IA, Puré R. (2010) Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism, Blood 115(24):5012-22. PMCID: PMC2890149
  • Blair, IA. (2010) Analysis of Estrogens in Serum and Plasma from Postmenopausal Women: Past Present, and Future. Steroids 75(4-5): 297-306. PMCID: PMC2840185
  • Mesaros C, Gugiu BG, Zhou R, Lee SH, Choi J, Laird J, Blair IA, Salomon RG. (2010) A 13-Oxo-9,10-epoxytridecenoate Phospholipid Analogue of the Genotoxic 4,5-Epoxy-2E- decenal: Detection in Vivo, Chemical Synthesis, and Adduction with DNA. Chem Res Toxicol 23, 516-527. PMCID: PMC2848942
  • Ciccimaro E, & Blair IA. (2010) Stable isotope-dilution LC-MS for quantitative biomarker analysis. Bioanalysis 2(2) 311-341. PMCID: PMC2843934
  • Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA. (2010) Liquid-chromatography mass spectrometry (LC-MS) of steroid hormone metabolites and its applications. J. Steroid Biochem Mol Biol 121:546-555. PMCID: PMC2894289
  • Blair, I.A. (2010) Analysis of endogenous glutathione-adducts and their metabolites. Biomed Chromatogr 24:29-38.
  • Byrns MC, Duan L, Lee SH, Blair IA, Penning TM. (2010) Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. J. Steroid Biochem Mol Biol 118(3): 177-187. PMCID: PMC2819162

2009

    Middleton MK, Zukas AM, Rubinstein T, Kinder M, Wilson EH, Zhu P, Blair IA, Hunter CA, Puré E. (2009) 12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis. Infect Immun. Infect Immun. 77(12):5690-5700. PMCID: PMC2786478

  • Rangiah K, Tippornwong M, Sangar V, Austin D, Tétreault M-P, Rustgi AK., Blair IA, Yu KH. (2009) Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer.  J. Proteome Res. 8(11):5153-64 . PMCID: PMC2783939
  • Park JH, Mangal D, Frey AJ, Harvey RG, Blair IA, Penning TM. (2009) The aryl-hydrocarbon receptor (AhR) facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. J Biol Chem. J Biol Chem. 2009 284(43):29725-34 . PMCID: PMC2785604
  • Lee SH, Blair IA. (2009) Targeted chiral lipidomics analysis of bioactive eicosanoid lipids in cellular systems. BMB Rep 42(7):401-410.
  • Zhu P, Jian W, Blair IA. (2009) A 4-oxo-2(e)-nonenal-derived glutathione-adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid. Free Rad Bio Med 47(7):953-61. PMCID: PMC2777738
  • Wei C, Zhu P, Shah SJ, Blair IA. (2009) 15-Oxo-eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Mol Pharmacol 76(3):516-25. PMCID: PMC2730384
  • Weibel GL, Joshi MR, Wei C, Bates SR, Blair IA, Rothblat GH. (2009) 15(S)-lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism. J Lipid Res 50(12):2371-6. PMCID: PMC2781309
  • Mitchell LE, Morales M, Khartulyari S, Huang Y, Murphy K, Mei M, Von Feldt JM, Blair IA, Whitehead AS. (2009) Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data. Clin Biochem. 42(12):1275-81
  • Jian W, Lee SH, Williams MV, Blair IA. (2009) 5-Lipoxygenase-mediated Endogenous DNA Damage. J Biol Chem 284(25):16799-807. PMCID: PMC2719316
  • Hahn CG, Banerjee A, Macdonald ML, Cho DS, Kamins J, Nie Z, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA. (2009) The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. PLoS ONE 4(4):e5251  PMCID: PMC2666803
  • Ciccimaro E., Hanks S. K., Yu K. H., and Blair I. A. (2009) Absolute Quantification of Phosphorylation on the Kinase Activation Loop of Cellular Focal Adhesion Kinase by Stable Isotope Dilution Liquid Chromatography/Mass Spectrometry. Anal Chem 81(9):3304-3313. PMCID: PMC2706532
  • Weibel GL, Joshi MR, Alexander ET, Zhu P, Blair IA, Rothblat GH. (2009) Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arterioscler Thromb Vasc Biol. 29(6):837-42. PMCID: PMC 2759530
  • Mesaros, C., Lee, S. H., Blair, I. A. (2009) Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 877(26):2736-45. PMCID: PMC2745066
  • Mangal D, Vudathala D, Park JH, Lee SH, Penning TM, Blair IA. (2009) Analysis of 7,8-Dihydro-8-oxo-2'-deoxy guanosine in Cellular DNA during Oxidative Stress. Chem Res Toxicol. 22(5):788-797. PMCID: PMC2684441
  • Shah SJ, Yu KH, Sangar V, Parry SI, Blair IA. (2009) Identification and Quantification of Preterm Birth Biomarkers in Human Cervicovaginal Fluid by Liquid Chromatography/Tandem Mass Spectrometry. J Proteome Res.. 8(5):2407-2417. PMCID: PMC2729452
  • Jin Y., Duan L., Lee S.H., Kloosterboer J., Blai I.A., and Penning T.M. (2009) Human cytosolic hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily catalyze reduction of conjugated steroids: implications for phase i and phase iii steroid hormone metabolism J Biol Chem 284(15):10013-10022. PMCID: PMC2665056
  • Matthews R.P., Lorent K., Mañoral-Mobias R., Huang Y., Gong W., Murray I.V.J., Blair I.A., and Pack M. (2009) TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase Development 136, 865-875. PMCID: PMC2685951
  • Xu D, Penning TM, Blair IA, Harvey RG. (2009) Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer. J Org Chem. 16;74(2):597-604.
  • Yu, KH, Barry CG, Austin D, Busch C.M, Sangar V, Rustgi A.K, Blair I.A. (2009) Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery. J Proteome Res 8(3):1565-1576. PMCID: PMC2652408
  • Ciccimaro E, Hanks SK, Blair IA. (2009) Quantification of Focal Adhesion Kinase Activation Loop Phosphorylation as a Biomarker of Src Activity. Mol Pharmacol. 75(3):658-66. PMCID: PMC2684915
  • Lu Z.-Y, Jensen LE, Huang Y, Kealey C, Blair IA, Whitehead A.S. (2009) The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells maintained under long-term low folate stress is mediated by the p38 MAPK pathway. Atherosclerosis 205(1):48-54. PMCID: PMC2715998 Supplementary Material
  • Yang, I.-Y. Hashimoto K., de Wind N., Blair I.A., and Moriya M. (2009) Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells. J Biol Chem. 284(1):191-8. PMCID: PMC2610493
  • Savitski AN, Mesaros C, Blair IA, Cohen NA, Kreindler JL. (2009) Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respir Res 10(1):120. PMCID: PMC2792224

2008

  • Lu Z.-Y., Morales M., Khartulyari S., Mei M., Murphy K.M., Stanislawska-Sachadyn A., Summers, C.M., Huang, Y. Von Feldt, J.M., Blair I.A., Mitchell L.E., Whitehead A.S. (2008) Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. Birth Defects Res A Clin Mol Teratol. 82(10):736-741.
  • Huang Y., Khartulyari S., Morales M.E., Stanislawska-Sachadyn A., Von Feldt J.M., Whitehead A.S., Blair I.A. (2008) Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 22(16):2403-12.
  • Blair, IA. (2008) DNA-adducts with lipid peroxidation products. J Biol Chem. 283(23):15545-9. PMCID: PMC 2414303.
  • Park J.H., Gelhaus S., Vedantam S., Oliva A.L., Batra A., Blair I.A., Troxel A. B., Field J., Penning T.M. (2008) The Pattern of p53 Mutations Caused by PAH o-Quinones is Driven by 8-oxo-dGuo Formation while the Spectrum of Mutations is Determined by Biological Selection for Dominance. Chem Res Toxicol, 21(5), 10391049. PMCID: PMC2671329.
  • Park J.H., Mangal D., Tacka K.A., Quinn A.M., Harvey R.G., Blair I.A., Penning T.M. (2008) Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proc Natl Acad Sci USA 105(19):6846-51. PMCID: PMC2383938
  • Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, Fitzgerald GA, Grosser T. (2008) Analysis of the zebrafish proteome during embryonic development. Mol Cell Proteomics. 7(5):981-94. PMCID: PMC2401336
  • Xu D, Duan Y, Blair IA, Penning TM, and Harvey RG. (2008) Synthesis of Dibenzo[def,p]chrysene, Its Active Metabolites, and Their 13C-Labeled Analogues. Org Lett 10(6):1059-1062
  • Shultz CA, Palackal NT, Mangal D, Harvey RG, Blair IA, Penning TM. (2008) Fjord-region Benzo[g]chrysene-11,12-dihydrodiol and Benzo[c]phenanthrene-3,4-dihydrodiol as Substrates for Rat Liver Dihydrodiol Dehydrogenase (AKR1C9): Structural Basis for Stereochemical Preference. Chem Res Toxicol. 21(3):668-677 PMCID: PMC2440589
  • Ran C, Dai Q, Ruan Q, Penning TM, Blair IA, Harvey RG. (2008) Strategies for Synthesis of Adducts of o-Quinone Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons with 2'-Deoxyribonucleosides J. Org. Chem., 73 (3), 992 -1003.
  • Zhu P, Oe T, and Blair IA. (2008) Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide. Rapid Commun Mass Spectrom. 22: 432-440.

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