Biochemistry and Molecular Biophysics Graduate Group

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Faculty Listed by Department

Biochemistry and Biophysics
Cancer Biology
Cell and Developmental Biology
Pathology and Laboratory Medicine
Radiation Oncology


Chemical and Biomolecular Engineering

School of Dental Medicine

School of Veterinary Medicine

Wistar Institute

Fox Chase Cancer Center


Department of Biochemistry & Biophysics

Ben E. Black, Ph.D. Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange

Bohdana M. Discher, Ph.D. Designing and interfacing proteins with membranes and electronic devices

Gideon Dreyfuss, Ph.D. Nuclear transport, hnRNP complexes, RNA-binding proteins, spinal muscular atrophy

P. Leslie Dutton, Ph.D. Oxido-reductase engineering; design and chemical synthesis of  redox proteins

S. Walter Englander, Ph.D. Protein folding; structure, structure change, and dynamics; H-exchange; NMR

Hua-Ying Fan, Ph.D. Regulation of chromatin structure and its impact on human diseases

Benjamin A. Garcia, Ph.D. Quantitative propeomics for understanding signaling pathways.

Roland G. Kallen, M.D., Ph.D. Structure, function, and regulation of expression of ion channels

Mark A. Lemmon, Ph.D. Biochemistry/biophysics of intermolecular interactions of growth factor receptor signaling

Mitchell Lewis, D.Phil. Gene regulation; protein crystallography; Structural basis of recognition

Paul A. Liebman, M.D. G-protein-receptor-arrestin mechanisms; visual signal  transduction.

Kristen W. Lynch, Ph.D. Mechanism and consequences of regulated alternative splicing

Ronen Marmorstein, Ph.D. Crystallography; biochemistry; transcription; cell-cycle; cancer

Hillary C.M. Nelson, Ph.D.,MPH

Kim A. Sharp, Ph.D. Theory of protein and nucleic acid structure and function

James Shorter, Ph.D. Regulation of beneficial or neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones, and small molecules

Cecilia Tommos, Ph.D. Protein radicals and electrochemistry; cation-x interactions; protein forced folding

Gregory D. Van Duyne, Ph.D. Structural biology; protein-protein interactions; x-ray  crystallography

Sergei A. Vinogradov, Ph.D. Functional macromolecules, optical imaging probes, porphyrin chemistry, dendrimer chemistry, oxygen microscopy and tomography

A. Joshua Wand, Ph.D. Protein structure and dynamics; molecular recognition and signal transduction; NMR spectroscopy

David F. Wilson, Ph.D. Integration of metabolism; oxidative phosphorylation; neuroregulation

Jeremy E. Wilusz, Ph.D., Regulation of noncoding RNA biogenesis and function


Department of Cancer Biology

Lewis A. Chodosh, M.D., Ph.D. Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging

Kathryn E. Wellen, Ph.D., Cancer cell metabolism, nutrient sensing

Xiaolu Yang, Ph.D. Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.

Department of Cell & Developmental Biology

Shelley L. Berger,  Ph.D. Role of adaptors in regulation of transcriptional activation in yeast and humans

Roberto Bonasio, Ph.D., Noncoding RNAs in chromatin biology and epigenetics

Maya Capelson, Ph.D., Role of NPC proteins in the regulation of gene expression.

Phong Tran, Ph.D. Cytoskeleton organization and cellular pattern formation

John W. Weisel, Ph.D. Structural studies of molecular/cellular mechanisms in blood clotting and fibrinolysis

Kenneth S. Zaret, Ph.D.,Investigating transcription factor interactions with chromatin

Department of Genetics

John I. Murray, Ph.D., Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy

Zhaolan (Joe) Zhou, Ph.D., Epigenetic control of genome function in brain development and disease

Department of Medicine

Charles S, Abrams, M.D. Phospholipid signaling in platelets & lymphocytes

Joel S. Bennett, M.D. Regulation of integrin function

Lawrence Brass, M.D., Ph.D. Molecular basis for intracellular signaling in vascular biology

Rahul M. Kohli, M.D., Ph.D. Investigating the enzymatic basis for diversity generation in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution

Mitchell A. Lazar, M.D., Ph.D., Transcriptional regulation of metabolism

Harvey Rubin, M.D., Ph.D. Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation and enzymology and cell biology of serine proteases and serine protease inhibitors

Department of Microbiology

Sara Cherry, Ph.D. Viral-host interactions and innate immunity

Department of Pathology & Laboratory Medicine

Yair Argon, Ph.D. Quality control of protein folding in the cell by molecular chaperones

F. Bradley Johnson, M.D., Ph.D., Telomeres, chromatin, DNA repair and their interface with cell senescence and aging

Virginia M.-Y. Lee, Ph.D. Pathobiology of Alzheimer's and Parkinson's disease

Michael S. Marks, Ph.D. Molecular mechanisms of intracellular protein transport and organelle biogenesis

X. Long Zheng, M.D., Ph.D. ADAMTS13 metalloprotease and microvascular thrombosis

Department of Pediatrics

Harry Ischiropoulos, Ph.D. Biological chemistry of nitric oxide; oxidative processes, protein aggregation and neurodegeneration

Department of Pharmacology

Paul H. Axelsen, M.D. Protein misfolding diseases and pathological protein-lipid interactions; rational drug design

Trevor M. Penning, Ph.D. Structure-function and gene regulation of the aldo-keto reductase superfamily

Aalim M Weljie, Ph.D., Circadian, sleep, environmental and cancer metabolism via metabolomics profiling

Department of Physiology

Joseph A. Baur, Ph.D. Molecular mechanisms of aging and caloric restriction

Roberto Dominguez, Ph.D. Actin cytoskeleton, protein phosphatase 1, structural biology

Kathryn M. Ferguson, Ph.D. Structural biology, growth factor receptor signaling, molecular mechanisms of protein-protein interactions

Ekaterina Grishchuk, Ph.D., Mechanisms that drive and control chromosome motions in mitosis

Yale E. Goldman,  M.D., Ph.D. Molecular motors and protein synthesis studied by single molecule biophysics

Paul Janmey, Ph.D. Cytoskeleton, biopolymer mechanics, phosphoinositides

Zhe Lu, M.D., Ph.D. Structure-function relationship of ion channels; molecular mechanisms of protein-protein interactions

E. Michael Ostap, Ph.D. Biochemistry of contractile proteins, biophysics of cell motility, and characterization of unconventional myosins

Benjamin L. Prosser, Ph.D. Mechano-signaling in the heart

Brian M. Salzberg, Ph.D. Multiple-site optical recording; excitation-secretion coupling; neural networks

Department of Radiation Oncology

Theresa Busch, Ph.D. Photodynamic therapy, tumor microenvironment

Department of Radiology

Jerry Glickson, Ph.D. Molecular imaging: NMR specroscopy and imaging of cancer; optical imaging of cancer; nanotechnology

Ravinder Reddy, Ph.D. Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques

Felix W. Wehrli, Ph.D. MRI of biomaterials microstructure, mathematical modeling, image processing



Department of Biology

Fevzi Daldal, Ph.D. Genetics, structure-function, regulation and biogenesis of cytochromes

Mark Goulian, Ph.D. Two-component signaling, bacterial regulatory circuits

Michael Lampson, Ph.D., Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinases

Department of Chemistry

Tobias Baumgart, Ph.D. Biomembrane function: thermodynamics, dynamics and mechanics

David Chenoweth, Ph.D. Development and application of synthetic methods for creating molecules that mimic or interact with biomolecules.

Feng Gai, Ph.D. Spectroscopic study of protein folding/missfolding

E. James Petersson, Ph.D.,Semi-synthesis of labeled proteins to probe and control conformation

Jeffery G. Saven, Ph.D. Theory, simulation and design of proteins and folding molecules

Department of Physics and Astronomy

Alison Sweeney, Ph.D.,



Department of Bioengineering

Ravi Radhakrishnan, Ph.D., Computational structural biology and systems biology; cell membrane mediated trafficking; targeted drug delivery; cancer signaling

Arjun Raj, Ph.D., Systems biology; developmental biology; non-coding RNA

Andrew Tsourkas, Ph.D., Developing molecular imaging probes to improve the disgnostic yield of non- or minimaly0invasive imaging procedures and diagnostic assays

Chemical and Biomolecular Engineering

Scott L. Diamond, Ph.D., Mechanobiology, gene transfer, blood systems biology, drug discovery, protease chemical-boiology

Matthew Lazzara, Ph.D., ErbB-mediated cell signaling


School of Dental Medicine

Kathleen Boesze-Battaglia, Ph.D. Tetraspanin protein structure and role in degenerative disease processes

School of Veterinary Medicine

John H. Wolfe, V.M.D., Ph.D. Glycoproteins; lysosomal enzymes; storage diseases; gene transfer into brain


Wistar Institute

Emmanuel Skordalakes, Ph.D. X-ray crystallography; telomere biology; cancer and aging

David Speicher, Ph.D. Cancer proteomics; structure-function of membrane associated proteins: protein chemistry and mass spectrometry


Fox Chase Cancer Center

Roland L. Dunbrack, Ph.D. Methods and applications of protein structure prediction

Heinrich Roder, Ph.D. NMR; protein folding mechanism; protein structure, dynamics and function