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| Shelley L. Berger, Ph.D.
Wistar Institute Hilary Koprowski Professor of Gene Expression and Regulation Adjunct Professor of Genetics and Biology
Ph.D., 1987, University of Michigan 207 Wistar Institute |
An important current area in research on gene and genome regulation is the direct role of alterations in chromatin structure in regulation of genetic processes. In fact, several enzymes that covalently modify nucleosomal histones are previously known transcription factors (coactivators or adaptors), recruited to promoters by DNA-bound activators. We focus on the adaptor and acetyltransferase, Gcn5, in yeast and human cells, and study its role as a HAT and FAT (histone and factor acetyltransferase). Recent studies examine the relationship between different types of histone modifications (acetylation, phosphorylation and methylation) and their role in gene regulation. Our work also focuses on the p53 tumor suppressor and transcriptional activator, whose function is modulated by post-translational modifications, including acetylation. Selected Publications: S. L. Berger (2000) Gene regulation: local or global? Nature 408:412-415. Lo, W.-S, R. Trievel, J. Rojas, L. Duggan, J.-Y, Hsu, C. D. Allis, R. Marmorstein and S. L. Berger (2000) Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Molecular Cell 5:917-926. Belotserkovskaya, R., D. Sterner, M. Deng, M. Sayre, P. Lieberman and S. L. Berger (2000) Inhibition of TBP function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters. Mol. Cell. Biol. 20:634-647. Sterner, D. and S. L. Berger (2000) HATs and FATs: acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev. 64:435-59. Liu, L., D. Scolnick, R. Trievel, R. Marmorstein, T. Halazonetis and S. L. Berger (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell.Biol. 19:1202-09 |
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