Assistant Professor of Radiology

Ph.D., 2000, University of Pennsylvania (Biochemistry and Molecular Biophysics)

B1 Stellar-Chance Labs
Tel: (215) 898-2045
Fax: (215) 573-2113
Email: ari@mail.mmrrcc.upenn.edu

Borthakur MMRRCC Page

The goal of our research is to develop non-invasive and non-destructive techniques for the study of Alzheimer’s Disease and arthritis. We facilitate timely clinical diagnoses by inventing and improving MRI pulse sequences and hardware. Our multi-nuclear and relaxometric techniques are routinely applied in model systems as well as in clinical research. We maintain active partnerships with faculty from Pathology, Neurology, Orthopedic Surgery and Rheumatology departments and recruit doctoral candidates from Biophysics and Bioengineering graduate programs.

Selected Publications   

Borthakur A, Sochor M, Davatzikos C, Melhem ER, Trojanowski JQ, Clark CM. (2008) T1ρ of Alzheimer's Disease. Neuroimage (in press).

Nguyen, AM, Johannessen W, Yoder JH, Wheaton AJ, Vresilovic EJ, Borthakur A, Elliott, DM. (2008) Noninvasive quantification of human nucleus pulposus pressure using T1ρ-weighted MRI as a biomarker of degeneration. Journal of Bone and Joint Surgery 90(4):796-802.

Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VMY, Trojanowski JQ. (2008) Biomarkers for early detection of Alzheimer pathology. Neurosignals 16(1):11-18.

Wang C, Auerbach JD, Witschey WRT, Balderston RA, Reddy R, Borthakur A. (2007) Advances in magnetic resonance imaging for the assessment of degenerative disc disease of the lumbar spine. Seminars in Spine Surgery 19:65-71.

Witschey WRT, Borthakur A, Elliott, MA, Mellon E, Niyogi S, Wallman DJ, Wang C, Reddy R. (2007) Artifacts in T1ρ-weighted imaging: compensation for B1 and B0 Field imperfections. Journal of Magnetic Resonance 186(1):75-85.

Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. (2006) Sodium and T1ρ MRI for molecular and diagnostic imaging of articular cartilage (Review Article). NMR in Biomedicine 19:781–821.

Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R. (2006) In vivo measurement of plaque burden in a mouse model of Alzheimer’s disease. Journal of Magnetic Resonance Imaging 24:1011-1017.