Assistant Professor & Associate Director, Center for Magnetic Resonance & Optical Imaging
Department of Radiology

Ph.D., 2000, University of Pennsylvania (Biochemistry and Molecular Biophysics)

B1 Stellar-Chance Labs
Tel: (215) 573-8482
Fax: (215) 573-2113
Email: ari@mail.mmrrcc.upenn.edu

Borthakur MMRRCC Page

The goal of our research is to develop non-invasive and non-destructive techniques for the study of Alzheimer’s Disease and arthritis. We facilitate timely clinical diagnoses by inventing and improving MRI pulse sequences and hardware. Our multi-nuclear and relaxometric techniques are routinely applied in model systems as well as in clinical research. We maintain active partnerships with faculty from Pathology, Neurology, Orthopedic Surgery and Rheumatology departments and recruit doctoral candidates from Biophysics and Bioengineering graduate programs.

Selected Publications   

Haris M, McArdle E, Fenty M, Singh A, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Borthakur A (2009) Early marker for Alzheimer’s Disease: Hippocampus T_1ρ estimation. Journal of Magnetic Resonance Imaging (in press).

Mellon EA, Pilkinton DT, Clark CM, Witschey WRT, Reddy R, Borthakur A (2009) Sodium MRI detection of mild Alzheimer Disease. American Journal of Neuroradiology

Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VMY, Trojanowski JQ. (2008) Biomarkers for early detection of Alzheimer pathology. Neurosignals 16(1):11-18.

Borthakur A, Sochor M, Davatzikos C, Melhem ER, Trojanowski JQ, Clark CM. (2008) T_1ρ of Alzheimer's Disease. Neuroimage 41:1199–1205.

Witschey WRT, Borthakur A, Elliott MA, Fenty M, Sochor M, Wang C, Reddy R. (2008) T_1ρ-prepared balanced gradient echo for rapid 3D T_1ρ MRI. Journal of Magnetic Resonance Imaging 28(3):744-754.

Auerbach JD, Johannessen W, Borthakur A, Wheaton AJ, Dolinskas CA, Balderston RA, Reddy R, Elliott DM. (2006) Quantitative in vivo assessment of human lumbar disc degeneration using T_1ρ-weighted magnetic resonance imaging. European Spine Journal 15:338-344.

Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R. (2006) In vivo measurement of plaque burden in a mouse model of Alzheimer’s Disease. Journal of Magnetic Resonance Imaging 24:1011-1017.

Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. (2006) Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage (Review Article). NMR in Biomedicine 19:781–821.