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Our lab is interested in understanding how proteins and lipids are sorted to different organelles within the cell. Investigation of the molecular sorting mechanisms responsible for the biogenesis and maintenance of intracellular organelles has been a central problem in cell biology for many years, and research in the field has provided many insights into human disease. We currently focus on two aspects of molecular sorting: regulation by phosphatidyl-inositol 3-kinase (PI3K) and Rab GTPases. Both of these enzymes (actually, families of enzymes) regulate membrane fusion and protein sorting and we are trying to elucidate specific molecular mechanisms by which the cell harnesses the activities of these enzymes.
Selected Publications: Shin, M.E., K.E. Ogburn, P.M. Gilbert, O.A. Varban and C.G. Burd (2001) FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes. J. Biol. Chem. 276:41388-41393. Gilbert, P.M. and C.G. Burd C.G. (2001) GDP dissociation inhibitor domain II required for Rab GTPase recycling. J. Biol. Chem. 276:8014-8020. Luan, P., S.D. Emr, W.E. Balch and C.G. Burd (1999) Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. J. Biol. Chem. 274:14806-14817. Burd, C.G. and S.D. Emr (1998) Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Molec. Cell 2:157-162. |
