Isaac Norris Professor of Biochemistry and Biophysics
Howard Hughes Medical Institute Investigator
Ph.D., 1978, Harvard University
(Biological Chemistry)

328 Clinical Research Building
Tel.: 215-898-0398, 215-898-0172
Fax: 215-573-2000
Email: gdreyfuss@hhmi.upenn.edu

Dreyfuss Lab Homepage

Dreyfuss Departmental Page

Howard Hughes Medical Institute Page

The research efforts of the Dreyfuss laboratory are presently focused on four interrelated topics:

The transport of proteins and RNAs between the nucleus and the cytoplasm.

The molecular function of SMN (Survival of Motor Neurons), the protein product of the Spinal Muscular Atrophy (SMA) disease gene

The structure and function of the hnRNP proteins, with particular focus on the role of these proteins in the formation and function of mRNA

Novel phage display methods for identification of interacting proteins.

Selected Publications:

Kataoka, N., J. Yong, V.N. Kim, F. Velazquez, R.A. Perkison, F. Wang and G. Dreyfuss (2000)  Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol. Cell 6:673-682.

Nakielny, S. and G. Dreyfuss (1999)  Transport of proteins and RNAs in and out of the nucleus. Cell 99:677-690.

Pellizzoni, L., N. Kataoka, B. Charroux and G. Dreyfuss (1998)  A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell 95:615-624.

Fischer, U., Q. Liu and G. Dreyfuss (1997)  A complex containing SMN and SIP1 has an essential role in spliceosomal snRNPs biogenesis. Cell 90:1023-1029

Liu, Q., F. Wang and G. Dreyfuss (1997)  The spinal muscular atrophy disease gene product (SMN) and its associated protein, SIP1, are in a complex with spliceosomal snRNP proteins. Cell 90:1013-1021.

Pollard, V.W., W.M. Michael, S.  Nakielny, M.C. Siomi, F. Wang and G. Dreyfuss (1996) A novel receptor-mediated nuclear protein import pathway. Cell 86:985-994.