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Ph.D., 1967, University of Wales (Biochemistry) 1005 Stellar-Chance
Laboratories |
The Dutton lab is interested in determining factors governing electron tunneling through natural proteins engaged in electron transfer, energy conversion, signaling, regulation and enzyme redox catalysis. We are also involved in de novo design and synthesis of proteins engineered to perform natural functions such as electron transfer, proton translocation, charge driven conformational changes and redox catalysis in structured highly simplified settings. Selected Publications: Jones, A.K., Lichtenstein, B.R., Dutton, A., Gordon, G., and Dutton, P.L. (2007) Synthetic hydrogenases: Incorporation of an iron carbonyl thiolate into a designed peptide. J. Am. Chem. Soc. (Communication) 129:14844-14845. Koder, R.L., Lichtenstein, B.R., Cerda, J.F., Miller, A-F., and Dutton, P.L. (2007) A flavin analogue with improved solubility in organic solvents. Tetrahedron Letters 48:5517-5520. Dutton, P.L., Munro, A.W., Scrutton, N.S., and Sutcliffe, M. (2006) Introduction. Quantum catalysis in enzymes: Beyond the transition state theory paradigm. Phil. Trans. R. Soc B 361:1293-1294. Koder, R.L., Valentine, K.G., Cerda, J, Noy, D., Wand, A.J., and Dutton, P.L. (2006) Nativelike structure in designed four α-helix bundles driven by buried polar interactions. J. Am. Chem. Soc. (Communication) 128(45):14450-14451. Moser, C.C., Farid, T.A., Chobot, S.E., and Dutton, P.L. (2006) Electron tunneling chains of mitochondria. Biochem Biophysics Acta 1757:1096-1109. Moser, C.C., Page, C.C., and Dutton, P.L. (2006) Darwin at the molecular scale: Selection and variance in electron tunneling proteins including cyctochrome c oxidase. Phil. Trans. R. Soc. B 361:1295-1305. Discher, B., Noy, D., Strzalka, J., Ye, S., Moser, C.C., Lear, J., Blasie, J.K., and Dutton, P.L. (2005) Design of amphiphilic protein maquettes: Controlling assembly, membrane insertion, and cofactor interactions. Biochemistry 44:12329-12343. Osyczka, A., Moser, C.C., Daldal, F., and Dutton, P.L. (2004) Reversible redox energy coupling in electron transfer chains. Nature 427:607-612. Darrouzet, E., M. Valkova-Valchanova, C.C. Moser, P.L. Dutton and F. Daldal (2000) Uncovering the [2Fe2S] domain movement in cytochrome bc1: implications for energy conversion and a target for antibiotics. Proc. Natl. Acad. Sci. USA 97:4567-4572. Page, C.C., X. Chen, C.C. Moser and P.L. Dutton (1999) Natural engineering principles of electron tunneling in biological energy and chemical conversions. Nature 402:47-52. Shifman, J.M., C.C. Moser, W.A. Kalsbeck, D.F. Bocian and P.L. Dutton (1998) Functionalized de novo designed proteins: mechanism of proton coupling to oxidation/reduction heme protein maquettes. Biochemistry 37:16815-827. Gibney, B.R., S.E. Mulholland, F. Rabanal and P.L. Dutton (1996) Ferredoxin and ferredoxin-heme maquettes. Proc. Natl. Acad. Sci. USA 93:15041-15046. Robertson, D.E., R.S. Farid, C.C. Moser, J.L. Urbauer, S.E. Mulholland, R. Pidikiti, J.D. Lear, A.J. Wand, W.F. DeGrado and P.L. Dutton (1994) Design and Synthesis of Multihaem Proteins. Nature 368:425-432. |
