Professor Biochemistry and Biophysics
M.D., 1958, Johns Hopkins University

143 Anatomy-Chemistry
Tel.: 215-898-6917
Fax: 215-573-8093
Email: liebmanp@mail.med.upenn.edu

Liebman Departmental Page
Liebman Lab Page
  1. Analysis of misfolding of signaling proteins upon loss of their obligatory small ligand. Role of misfolding in biological aging
  2. Thermodynamics, kinetics and protein-protein contact mechanism of signal transduction proteins.
  3. Computational modeling, complex systems analysis of simultaneous actions of GTP'ase activator protein, phosducin, arrestin and receptor phosphorylation in signal transduction.
  4. Rich interplay of analytical math, biophysical instrumentation, reaction chemistry and physics, molecular graphics computing, dual wavelength kinetic spectroscopy, intrinsic tryptophan and tyrosine fluorescence dynamic and static light scattering, centrifugal and gel filtration polymer size analysis, microcalorimetry, CD, osmotic stress, hydrostatic pressure plus all the standard wet lab preparation techniques.

Selected Publications:

  1. R.D. Hamer, S.C. Nicholas, D. Tranchina, P.A. Liebman and T.D. Lamb (2003) Multiple Steps of Phosphorylation of Activated Rhodopsin Can Account for the Reproducibility of Vertebrate Rod Single-photon Responses. The Journal of General Physiology 122:419-444
  2. Y.Ishizawa, R. Pidikiti, P.A. Liebman, and R.G. Eckenhoff (2002) G Protein-Coupled Receptors as Direct Targets of Inhaled Anesthetics. Molecular Pharmacology 61:945-952
  3. B. Zelent, Y. Veklich, J. Murray, J. H. Parkes, S.K. Gibson, and P. A. Liebman (2001) Rapid Irreversible G Protein Alpha Subunit Misfolding Due to Intramolecular Kinetic Bottleneck that Precedes Mg2+ "Lock" after GTP/GDP Exchange Biochemistry 40:9647-9656
  4. J.W. Tanner, J.S. Johansson, P.A. Liebman, and R.G. Eckenhoff (2000) Predictability of Weak Binding from X-ray Crystallography: Inhaled Anesthetics and Myoglobin. Biochemistry 40:5075-5080
  5. Gibson, S.K, J.H. Parkes, and P.A. Liebman (2000) Phosporylation Modulates the Affinity of Light-activated Rhodopsin for G Protein and Arrestin. Biochemistry 39:5738-574