Associate Professor of Biochemistry and Biophysics
Ph.D. 1985, Massachusetts Institute of Technology (Biology)

813A Stellar-Chance Laboratories
Tel.: 215-573-7473
Email: hnelson@mail.med.upenn.edu

Nelson Departmental Page

Recent Publications:

Dashnau, J.L., Conlin, L.K., Nelson, H.C., and Vanderkooi, J.M.  (2008) Water structure in vitro and within Saccharomyces cerevisiae yeast cells under conditions of heat shock. Biochimica et Biophysica Acta 1780:41-50.

Conlin, L.C. and Nelson, H.C.M. (2007) Trehalose affects the transcriptional activity of yeast heat shock transcription factor. Mol. Cell. Biol. 27:1505-1515.

Zhao, X., Shi, H., Sevilimedu, A.,  Liachko, N., Nelson, H.C.M., and Lis, J.T. (2006) An RNA aptamer that interferes with the DNA binding of the HSF transcription activator. NAR 34:3755-3761.

Eastmond, D.L. and Nelson, H.C.M. (2006) Genome-wide analysis reveals new roles for the activation domains of the Saccharomyces cerevisiae heat shock transcription factor (Hsf1) during the transient heat shock response.  JBC 281:32909-32921.

Ferguson, S.B., Anderson, E.A., Harshaw, R.B., Thate, T., Craig, N.L., and Nelson, H.C.M. (2005)  Protein kinase A regulates constitutive expression of small heat shock genes in an Msn2p/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics 169:1203-1214.

Bulman, A.L. and Nelson, H.C.M. (2005) Role of trehalose and heat in the structure of the C-terminal activation domain of the heat shock transcription factor. Proteins 58:826-835.