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B1-Stellar-Chance
Laboratories |
My research interests are In developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer’s Disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection and spin locking for studying molecular dynamics in biological tissues in vivo. In particular, sodium and spin-locking MRI are targeting to map proteoglycan molecules (e.g. Aggrecan) in the connective tissues in vivo. Indirect 17O MRI is aimed at studying cerebral blood flow and cerebral oxidative metabolism and tumor perfusion and metabolism. Spin-locking MRI is being developed to impart novel contrast in various tissue types (brain, connective tissues and tumors), macromolecular ordering in tissues, and visualize and quantify Amyloidal plaques in Alzheimer’s disease in vivo. Selected Publications: Akella S.V.S., Regatte R. R., Wheaton A.J., Borthakur A., Reddy R. (2004) Reduction of residual dipolar interaction in cartilage by spin-lock technique. Magn. Reson. Med. (in press). Borthakur A, Wheaton AJ, Gougoutas AJ, Akella SV, Regatte RR, Charagundla SR, Reddy R.(2004) In vivo measurement of T1ρ dispersion in the human brain at 1.5 Tesla. J Magn Reson Imaging. 19:403-409 Borthakur A, Charagundla SR, Wheaton AJ, Reddy R. (2004) T1ρ-weighted MRI using a surface coil to transmit spin-lock pulses. J Magn Reson. 167:306-316. Regatte, R.R., Sarma, V.S.A., Wheaton, A.J., Borthakur, A., J.B. Kneeland, and R. Reddy (2004) 3D-T1ρ-relaxation mapping of articular cartilage in vivo. Acad. Radiol. 11:741-749. Tailor, D.R., Baumgardner, J.E., Regatte, R.R., McLaughlin, A.C., Leigh, J.S., Reddy, R. (2004) Proton MRI of metabolically produced H217O using an efficient 17O2 delivery system. NeuroImage 22:611-618. |
