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1 Founders
Pavilion |
Research of the Laboratory is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans. The current focus of the Laboratory is on the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy", and new methods for the study of bone matrix and mineral micro- and nanostructure. A second line of research focuses the development of MRI-based methods for noninvasive measurement of blood oxygen saturation Additional projects deal with ultrahigh-resolution microscopy of neuronal architecture in spinal cord injury models as well as methods for indirect assessment of tissue microstructure by means of diffusion diffraction and multiple quantum coherence imaging. Selected Publications: Fernandez-Seara, M.A., A. Techawiboonwong, J.A. Detre, F.W. Wehrli (2006) MR Susceptometry for measuring global brain oxygen extraction. Magn Reson Med 55:967–973. Wehrli, F.W., H.K.Song, P.K. Saha, A.C. Wright (2006) Quantitative MRI for the assessment of bone structure and function NMR Biomed 19:731-764. Chin, C-L., F.W. Wehrli, Y. Fan, S.N. Hwang, E.D. Schwartz, J. Nissanov, D.B. Hackney (2004) Assessment of axonal fiber tract architecture in rat spinal cord by localized NMR q-space imaging: simulations and experimental studies. Magn Reson Medicine 52:733-40. Takahashi, M., D.B. Hackney, G. Zhang, S.L Wehrli, A.C. Wright, W.T. O'Brien, H. Uematsu, F.W. Wehrli, M.E. Selzer (2002) Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord. Proc Natl Acad Sci USA 99(25):16192-16196. Gomberg, BG, P.K. Saha, H.K. Song, S.N. Hwang, F.W. Wehrli FW. (2000) Application of topological analysis to magnetic resonance images of human trabecular bone. IEEE Trans Med Imaging, 19:166-174. |
