Chemical and
Structural Biology

 

Yair Argon, Ph.D.
Quality control of protein folding in the cell by molecular chaperones

Paul H. Axelsen, M.D.
Biophysical studies of molecular recognition and rational drug design. 

Tobias Baumgart, Ph.D.
Biomembrane function: thermodynamics, dynamics and mechanics

Ben E. Black, Ph.D.
Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange

Kathleen Boesze-Battaglia, Ph.D.
Tetraspanin protein structure and role in degenerative disease processes

Barry S. Cooperman, Ph.D.
Enzyme catalysis, regulation,  ribosomes; kinetics; probes; bioorganic chemistry

William F. DeGrado, Ph.D.
Peptide and protein design.

Roberto Dominguez, Ph.D.
Actin cytoskeleton, protein phosphatase 1, structural biology

Roland L. Dunbrack, Ph.D.
Methods and applications of protein structure prediction.

P. Leslie Dutton, Ph.D.
Oxido-reductase engineering; design and chemical synthesis of  redox proteins

S. Walter Englander, Ph.D.
Protein folding; structure, structure change, and dynamics;  H-exchange; NMR

Kathryn M. Ferguson, Ph.D.
Molecular interactions in signal transduction pathways; X-ray crystallography

Feng Gai, Ph.D.
Spectroscopic study of protein folding/missfolding

Yale E. Goldman,  M.D., Ph.D.
Motor proteins studied by photochemistry and spectroscopy

Doron Greenbaum, Ph.D.
Protease function, chemical biology, proteomics, biochemistry, cell biology, malaria

Robin M. Hochstrasser, Ph.D.
Photochemical and photobiological dynamics; nonlinear optical spectroscopy

Harry Ischiropoulos, Ph.D.
Biological chemistry of nitric oxide; oxidative processes, protein aggregation and neurodegeneration.

Virginia M.Y. Lee, Ph.D.
Pathobiology of Alzheimer's and Parkinson's disease

Mark A. Lemmon, Ph.D.
Biochemistry/biophysics of intermolecular interactions of growth factor receptor signaling

Mitchell Lewis, D.Phil.
Gene regulation; protein crystallography; structural basis of recognition

Paul A. Liebman, M.D.
G-protein-receptor-arrestin mechanisms; visual signal transduction

Ronen Marmorstein, Ph.D.
Crystallography; biochemistry; transcription; cell-cycle; cancer 

Hillary C.M. Nelson, Ph.D.
Structural biology; transcription; protein-DNA interactions; heat shock response

Tomoko Ohnishi, Ph.D.
Structure-function studies of respiratory components; biological EPR spectroscopy

E. Michael Ostap, Ph.D.
Biochemistry of contractile proteins, biophysics of cell motility, and characterization of unconventional myosins

Trevor M. Penning, Ph.D.
Structure-function of aldo-keto reductases: role in steroid hormone action and chemical carcinogenesis.

Heinrich Roder, Ph.D. NMR;
protein folding mechanism; protein structure, dynamics and function

Harvey Rubin, M.D., Ph.D.
Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation and enzymology and cell biology of serine proteases and serine protease inhibitors

Casim A. Sarkar, Ph.D.
Protein engineering

Jeffery G. Saven, Ph.D.
Theory, simulation and design of proteins and folding molecules

Kim A. Sharp, Ph.D.
Theory of protein and nucleic acid structure and function

James Shorter, Ph.D.
Regulation of beneficial or neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones, and small molecules

Emmanuel Skordalakes, Ph.D. X-ray crystallography; telomere biology; cancer and aging

David Speicher, Ph.D.
Cancer proteomics; structure-function of membrane associated proteins: protein chemistry and mass spectrometry

Cecilia Tommos, Ph.D.
Protein radicals and electrochemistry; cation-π interactions; protein forced folding

Jane M. Vanderkooi, Ph.D.
Fluorescence; infrared; heme proteins

Gregory D. Van Duyne, Ph.D.
Structural biology; protein-protein interactions; x-ray  crystallography

A. Joshua Wand, Ph.D., Graduate Group Chair
Protein structure and dynamics; molecular recognition and signal transduction; NMR spectroscopy

John W. Weisel, Ph.D.
Structural studies of molecular/cellular mechanisms in blood clotting and fibrinolysis.

Takashi Yonetani, Ph.D.
Structure, mechanism, and spectroscopy of hemoproteins and heme enzymes

X. Long Zheng, M.D., Ph.D.
ADAMTS13 metalloprotease and microvascular thrombosis