Biochemistry and Molecular Biophysics Graduate Group

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BMB 508 - Macromolecular Biophysics: Principles and Methods

Fall, every year

Course Director:

Kim Sharp, Ph.D., sharpk@mail.med.upenn.edu

This course introduces students to the physical and chemical properties of proteins, nucleic acids, and membranes. The emphasis in BMB 508 is on thermodynamics and structure, with several lectures devoted to the biophysical methods used to study biological macromolecules. This is intended to be a first course for graduate students with an undergraduate background in physics, chemistry, or biology.

Required Texts (in stock at Penn Bookstore):

Cantor & Schimmel, Biophysical Chemistry Part 2: Techniques for the Study of Biological Structure and Function, Freeman & Co.

van Holde, Johnson, & Ho,Principles of Physical Biochemistry, 2nd Edition, Prentice Hall.


Sample outline:

Lecture Topic
1 Introduction/Molecular interactions
2 Molecular interactions
3 Molecular interactions
4 Ligand Binding
5 Denaturation, Folding
6 Calorimetry
7 Sedimentation
8 NMR Spectroscopy
9 NMR Spectroscopy
10 NMR Spectroscopy
11 EPR Spectroscopy
12 Spectroscopic probes
13 Spectroscopic probes
  Mid-term Examination
14 Optical imaging
15 Magnetic Resonance Imaging
16 X-ray Diffraction
17 X-ray Diffraction
18 Molecular analysis - modeling
19 Protein Structure
20 Protein Structure
21 Nucleic Acids Structure
  No class
22 High order structure, electron microscopy
23 Scattering methods
24 Protein chemistry
25 Protein design & engineering
26 Protein design & engineering
  Final Examination