Spring, every year
Course Director:
Kathryn Ferguson, Ph.D., ferguso2@mail.med.upenn.edu
After some introductory material on macromolecules, lectures will focus on the key biochemical 'task areas' of living cells. The course progresses from primarily molecular level events such as storage & translation of genetic information, creation, control & removal of proteins etc. to higher organization levels such as metabolic pathways, signaling pathways, regulation and homeostasis. The presentation for each topic will be 'vertically integrated'. Each section will cover structure details of the relevant molecules, appropriate binding/catalysis events, regulatory aspects, and how they fit into the relevant pathway(s) and cell function.
Prerequisites:BMB 508 and BIOM 600, or permission of instructor
Recommended Textbooks: Berg, Tymoczko & Stryer, Biochemistry, 7thEdition, W.H. Freeman
Course Outline:
Proteins |
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1 |
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2 |
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Composition and properties of biological membranes |
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3 |
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4 |
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5 |
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Management of genetic information |
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6 |
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7 |
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8 |
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9 |
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Transcription and modulation of DNA/RNA |
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10 |
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11 |
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12 |
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13 |
Translation and the ribosome |
14 |
Motor proteins |
Midterm Exam |
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Proteins that modify the function of proteins |
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15 |
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16 |
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17 |
GTPases |
Protein Folding & Misfolding |
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18 |
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19 |
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20 |
Protein Breakdown: Proteases, degradation, the proteosome |
Cellular regulatory circuits |
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21 |
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22 |
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Metabolism |
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23 |
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24 |
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25 |
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26 |
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27 |
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28 |
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Final Exam |
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