Fall, every year
Course Directors:
Yair Argon, Ph.D.,yargon@mail.med.upenn.edu
Harry Ischiropoulos, Ph.D. ischirop@mail.med.upenn.edu
Protein misfolding and aggregation has been associated with a number of human diseases, ranging from Alzhemier's and Parkinson's Disease to Respiratory Distress Syndrome, alpha-1-antitrypsin deficiency and Mad Cow Disease. This seminar course will include lectures, directed readings and student presentations to cover seminal and current concepts in the biochemistry and cell biology of conformational diseases. Examples of topics: effects of mutations on folding in the cell, inclusion bodies formation, protein degradation pathways, and effects of protein aggregation on cell function.
Prerequistes: BIOM 600 or equivalent; graduate students only and with permission of course director
| Class Syllabus Fall 2010 | ||
| 09/8/10 |
Introduction: Course structure and administration
Protein folding and misfolding in the cell |
Argon + Ischiropoulos Argon |
| 09/15/10 |
Protein folding and misfolding in the cell (continued) | Argon |
| 09/22/10 |
Proteostasis in yeast Student presentation |
Shorter |
| 09/29/10 |
Yeast models for ALS Student presentation |
Gitler |
| 10/06/10 |
Prion diseases studied in yeast and mice Student presentation |
Kalb |
| 10/13/10 |
Fly models for polyglutamine repeats Student presentation |
Bonini |
| 10/20/10 |
Mouse models for PD/ALZ Student presentation |
Giasson |
| 10/27/10 |
Frog oocyte model to study CFTR Student presentation |
Rubenstein |
| 11/03/10 |
Two student presentations | |
| 11/10/10 |
Two student presentations | |
| 11/17/10 |
Two student presentations | |
| 12/01/10 |
Two student presentations | |
| 12/08/10 |
Two student presentations | |