Biochemistry and Molecular Biophysics Graduate Group

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BMB 518 (CAMB/NGG 615) - Protein Conformation Diseases

Fall, every year

Course Directors:
Yair Argon, Ph.D.,
yargon@mail.med.upenn.edu
Harry Ischiropoulos, Ph.D. ischirop@mail.med.upenn.edu

Protein misfolding and aggregation has been associated with a number of human diseases, ranging from Alzhemier's and Parkinson's Disease to Respiratory Distress Syndrome, alpha-1-antitrypsin deficiency and Mad Cow Disease. This seminar course will include lectures, directed readings and student presentations to cover seminal and current concepts in the biochemistry and cell biology of conformational diseases. Examples of topics: effects of mutations on folding in the cell, inclusion bodies formation, protein degradation pathways, and effects of protein aggregation on cell function.

Prerequistes: BIOM 600 or equivalent; graduate students only and with permission of course director

Class Syllabus Fall 2010
09/8/10
Introduction: Course structure and administration
Protein folding and misfolding in the cell
Argon + Ischiropoulos
Argon
09/15/10
Protein folding and misfolding in the cell (continued)

Argon

09/22/10
Proteostasis in yeast
Student presentation
Shorter
09/29/10
Yeast models for ALS
Student presentation

Gitler

10/06/10
Prion diseases studied in yeast and mice
Student presentation

Kalb

10/13/10
Fly models for polyglutamine repeats
Student presentation

Bonini

10/20/10
Mouse models for PD/ALZ
Student presentation
Giasson
10/27/10
Frog oocyte model to study CFTR
Student presentation

Rubenstein

11/03/10
Two student presentations  
11/10/10
Two student presentations  
11/17/10
Two student presentations  
12/01/10
Two student presentations  
12/08/10
Two student presentations