Spring - even-numbered years (1/2 semester; 1/2 credit)
Yale E. Goldman, M.D., Ph.D., firstname.lastname@example.org, tel: 215-898-4017
Roberto Dominguez, Ph.D., email@example.com, tel: 215-573-4559
E. Michael Ostap, Ph.D., firstname.lastname@example.org, tel: 215-573-9758
This course will provide an introduction to the biochemical, structural, and mechanical properties of energy-transducing enzymes. We will emphasize the relationships of mechanical, thermal, and chemical forces in mechano-enzyme function. Introductory lectures will be given by the faculty, and students and faculty will present papers from current scientific literature. The format of the course is designed to foster active discussion of the subject with an emphasis on the critical evaluation of the literature. Participants will write and submit, on the day of each presentation, five questions on each of the selected literature papers. Grading will take account personal presentations, participation during other students’ presentations, homework and written questions. Attendance is expected at all sessions; please inform faculty of necessary absences beforehand.
Course Materials: “Mechanics of Motor Proteins and the Cytoskeleton,” by Jonathon Howard is the required text book.
Basic Physical Principles
Mechanical Forces in Biophysics and Cell Biology
Mass, Stiffness and Damping of Proteins
Thermal Forces and Diffusion
Cytoskeletal Motor Proteins
Viral portal motors