Biochemistry and Molecular Biophysics Graduate Group

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Spring 2011 Courses

BMB 509 Macromolecular Biophysics II (required)
Sharp
M/W, 1:30 – 3:00 p.m.
255 Anatomy-Chemistry Bldg.

Prerequisites: BMB 508 or permission of instructor

This course introduces fundamental concepts in chemical kinetics and their application to problems in biochemistry such as protein folding and enzymology. There is an emphasis on dynamic processes in proteins and the techniques used to characterize them over a wide range of timescales. The latter half of the course focuses on emerging areas in biochemistry and biophysics including membrane biochemistry, single molecule methods and proteomics with an emphasis on mass spectrometry.

 

BMB 581 (BE 581) Techniques of Magnetic Resonance Imaging
Wehrli
M/W, 5 – 6:30 p.m.
255 Anatomy-Chemistry Bldg.

First class, Wednesday, January 12, 2011

Detailed introduction to the physics and engineering of magnetic resonance imaging as applied to medical diagnosis. Covered are magnetism, spatial encoding principles, Fourier analysis, spin relaxation, imaging pulse sequences and pulse design, contrast mechanisms, chemical shift, flow encoding, diffusion and perfusion and a discussion of the most relevant clinical applications.

BMB 601 Fundamentals of Magnetic Resonance
Reddy
Tu/Th, 2 – 3:00 p.m.
B1 Stellar-Chance Labs

First class, Thursday, January 13, 2011

This course introduces basic theoretical and experimental concepts of magnetic resonance and its applications in biochemistry, biology and medicine. Topics covered include description of the phenomenon of magnetic resonance, classical and quantum strategies to compute nuclear spin responses in liquids, solids and biological tissues, polarization transfer and multiple quantum effects and their applications in biomedicine. Nuclear spin relaxation in solid-state materials and in biological systems will be discussed. Concepts of magnetic resonance imaging, imaging strategies, image contrast, and diagnostic applications are discussed. The course includes several practicals dealing with the demonstration of NMR hardware and experiments to compute basic NMR parameters on high resolution and clinical MRI scanners. For further details of the course visit www.mmrrcc.upenn.edu

 

BMB 624 Ion Channels and Pumps
Kallen & Lu
M/W 10:00 – 11:30 a.m.
255 Anatomy-Chemistry Building
(1/2 credit; 01/12/11 to 03/14/11)

This course will introduce students to the fundamentals of ion channel function, with the course loosely organized around major classes of ion channels (voltage, mechanical and ligand gated). Discussion will focus on methods of study, mechanisms of ion selectivity and gating, and pathophysiology of human diseases (channelopathies). Intended for second-year graduate students or 1st year students with a strong background in biophysics or physiology.

BMB 627 Computer Programming for Biochemists and Biophysicists
Sharp & Van Duyne
M/W, 10:00 – 11:30 a.m.
255 Anatomy-Chemistry Bldg.
(1/2 credit; 03/04/11 to 04/26/11)

An introductory course on programming and algorithms for scientists with an emphasis on applications to biophysics. Students will learn to write, debug, and execute basic programs through lectures, in-class workshops, and programming projects outside of class.

BMB 632 Probing Structure and Function of Complex RNA-Protein Machines
Lynch
M/W, 3 – 4:30 p.m.
1001 Stellar-Chance Labs
(1/2 credit; 03/04/11 to 04/26/11)

RNA-Protein complexes or RNPs can range from simple assemblies to megadalton enzymatic machines.The latter include two of the most abundant and essential enzymatic complexes for converting genes to functional protein -the ribosome and the spliceosome. Understanding the molecular interactions that hold these RNPs together and how these complexes function has required the development of new techniques and pushed the boundaries of quantitative biochemistry. In this course we will take an in-depth look at general concepts common to many RNA binding proteins, the methods used to study protein-RNA and RNA-RNA interactions, and how the complex nature of large RNPs uniquely allow them to achieve their precise functions. The course will be a combination of both lectures and student-lead discussion of recent literature. Students will be evaluated based on their presentations of primary literature and their participation in class discussion.

BMB 650 Current Biochemical Topics (required; may also be taken a second time for elective credit)
Black & Shorter
W, 12:15 – 1:30 p.m (255 Anatomy-Chemistry Bldg.)
Th, 12:00 noon – 1:00 p.m. (Austrian Auditorium)
Th, 1:00 – 2:00 p.m., (248 Anatomy-Chemistry Bldg./JF Library)

First class, Wednesday, January 12

Participation in the "Dr. George W. Raiziss Biochemical Rounds", a weekly seminar program sponsored by the Department of Biochemistry and Biophysics. Pro­gram deals with a wide range of modern biochemical and bio­physical top­ics presented by established investigators selected from our faculty and by leading scientists from other institutions.

Tutorial, Independent Study and Lab Rotation Courses

BMB 598 Tutorial (may be taken one time only for elective credit)
Gitler

Literature studies in a specific research area under supervision of Biochemistry and Molecular Biophysics Graduate Group faculty, concluded by a written summary and a seminar presentation. Course offered fall, spring and summer semesters.

BMB 705 Prelim Exam Preparation Course (required)
Lemmon & Marmorstein
Fri, 1:30 – 3:00 p.m.
(1/2 credit; 01/21/11 to 03/11/11)

First class, Friday, January 7, 2011

This course is designed for second year BMB students to prepare them for the Preliminary Exam, which must be completed in the spring semester of the second year.

BMB 699 Laboratory Rotation -
Shorter

Supervised mini-projects for graduate students in BMB, seminar presentation required. Course offered fall, spring and summer semesters.

BMB 799 Independent Study (YRS 1- 2)