BMB 560 – Methods of Scientific Inquiry in Biological Systems
Wilson and Domotor
Tu / Th, 4 – 5:30 p.m.
1001 Stellar-Chance Labs

Prerequisites: graduate students in biological sciences or permission of instructors.

The foundational, social and methodological aspects of scientific reasoning in biomedical disciplines are discussed, including: 1) theories, laws, causal/functional explanation and experimental methodology in biology and medicine, 2) case studies in selected fields of biomedical sciences with special regards to strategies in concept and hypothesis formation, discovery, gathering evidence and testing and 3) social and moral factors pertinent to the research enterprise.

BMB 571 - Seminar Course on "The Biochemistry and Biophysics of Nucleotide Binding Proteins"
Rubin
Mondays, 12 noon - 2:00 p.m.
255 Anatomy-Chemistry Building

Student seminars on selected topics from current scientific literature.

BMB 581 (BE 581) - Techniques of Magnetic Resonance Imaging
Wehrli
Mon/Wed, 5:00 – 6:30 p.m.
255 Anatomy-Chemistry Bldg.

Detailed introduction to the physics and engineering of magnetic resonance imaging as applied to diagnostic medicine.  Covered are magnetism, spin relaxation, spatial encoding principles, Fourier analysis, imaging pulse sequence and pulse design, contrast mechanisms, chemical shift, flow encoding, diffusion and perfusion and a discussion of the most relevant clinical applications.

BMB 601 – Fundamentals of Magnetic Resonance
Leigh & Reddy
M / W, 2 – 3 p.m.
B1 Stellar-Chance Labs

This course introduces basic theoretical and experimental concepts of magnetic resonance and its applications in biochemistry, biology and medicine.  Topics covered include description of the phenomenon of magnetic resonance, classical and quantum strategies to compute nuclear spin responses in liquids, solids and biological tissues, polarization transfer and multiple quantum effects and their applications in biomedicine.  Nuclear spin relaxation in solid-state materials and in biological systems will be discussed.  Concepts of magnetic resonance imaging, imaging strategies, image contrast, and diagnostic applications are discussed.  The course includes several practicals dealing with the demonstration of NMR hardware and experiments to compute basic NMR parameters on high resolution and clinical MRI scanners. For further details of the course visit: www.mmrrcc.upenn.edu

BMB 619 - Protein Folding
Englander & Axelsen

Introduction to the folding of soluble proteins mainly but also membrane proteins; critical readings in the current literature and important earlier literature; class discussion of papers with didactic lectures as required. Exposure to principles and use of equilibrium, kinetics, thermodynamics and the range of biophysical technologies as they occur in the real literature.

Tutorial, Independent Study and Lab Rotation Courses

BMB 598 – Tutorial
Black

Literature studies in a specific research area under supervision of Biochemistry and Molecular Biophysics Graduate Group faculty, concluded by a written summary and a seminar presentation.

BMB 705 – Prelim Exam Preparation Course
DeGrado

Time and place to be determined

BMB 699 – Laboratory Rotation
Ferguson

Supervised mini-projects for graduate students in BMB, seminar presentation required.

BMB 799 – Independent Study (Year 1 – 2)

BMB 999 – Independent Study (Years 3 – 5)