CELL BIOLOGY and BIOCHEMISTRY (BIOM 600)

Fall

Monday/Wednesday/Friday
10:30 a.m. -12:00 p.m.
Austrian Auditorium

Course Director:

Michael Ostap (573-9758)

Co-directors:

Theme I : Mark Lemmon (898-3072) and Mickey Marks (898-3204)
Theme II : Zhe Lu (573-7711)
Theme III : Mike Ostap (573-9758)
Theme IV : Morrie Birnbaum (898-5001)

Discussion Groups: Fridays

Textbook: "Molecular Biology of the Cell" Eds. Alberts, et al. 4th ed. (2002)

 

Date

Topic

Lecturer

Mon Sept 8

Introduction to Class

M. Ostap

Wed Sept 10

Purification, analysis, and manipulation of biomolecules

M. Milla

Fri Sept 12

Microscopy Techniques

J. Murray

Mon Sept 15

Basics of protein structure and folding / thermodynamics

K. Sharp


Theme I: Cell Compartmentation

Wed Sept 17

Themes in cellular compartmentation
Structures and properties of biomembranes

M. Marks
M. Lemmon

Fri Sept 19

Cellular Quality Control
Discussion Groups: Biochemistry Quiz

M. Marks

Mon Sept 22

Protein biogenesis and translocation into the endoplasmic reticulum

M. Lemmon

Wed Sept 24

Protein folding/ER quality control

R. Doms

Fri Sept 26

Basics of Vesicular Transport
Discussion Groups: Cell Compartmentation

M. Marks

Mon Sept 29

Protein sorting in the vacuolar system

C. Burd

Wed Oct 1

Protein internalization and degradation

M. Marks

Fri Oct 3

Exocytosis and regulated secretion
Discussion Groups: Cell Compartmentation

M. Birnbaum

Mon Oct 6

Mitochondria

N. Avadhani

Wed Oct 8

Nucleus

M. Matunis

Fri Oct 10

Exam 1
Discussion Groups: Cell Compartmentation


Theme II: MEMBRANES AND SOLUTE TRANSPORT

Mon Oct 13

Principles of solute transport

K. Foskett

Wed Oct 15

Introduction to kinetics of processes that occur in cell biology

J. Jarrett

Fri Oct 17

Ion channels I
Discussion Groups: Kinetics

Z. Lu

Mon Oct 20

Ion channels II

Z. Lu

Wed Oct 22

Protein interactions in ion channels: function and assembly

C. Deutsch

Fri Oct 24

Protein-protein interactions and molecular recognition
Discussion Groups: Membranes and Solute Transport

M. Lemmon

Mon Oct 27

Integrated functions of channels

K. Foskett


Theme III: CELL MOTILITY AND ADHESION

W Oct 29

Microtubules and dynamics

E. Holzbaur

Fri Oct 31

Microtubule cytoskeleton
Discussion Groups: Membranes and Solute Transport

E. Holzbaur

Mon Nov 3

Actin and myosin cytoskeleton

M. Ostap

Wed Nov 5

Actin cytoskeleton and motility

M. Ostap

Fri Nov 7

Cell adhesion
Discussion Groups: Motility and Adhesion

D. Boettiger (?)

Mon Nov 10

Cell-extracellular matrix interactions

D. Boettiger (?)

Wed Nov 12

Mitosis and cytokinesis

E. Bi

Fri Nov 14

Exam 2
Discussion Groups: Motility and Adhesion


THEME IV: SIGNAL TRANSDUCTION

Mon Nov 17

Introduction to signal transduction
Principles of metabolism and pathways

M. Birnbaum
M. Lemmon

Wed Nov 19

Nuclear receptor signaling

M. Lazar

Fri Nov 21

G-proteins
Discussion Groups: Signal Transduction

D. Manning

Mon Nov 24

Phospholipases
Calcium Signaling

B. Wolf
K. Foskett

Wed Nov 26

Activation by tyrosine phosphorylation

M. Birnbaum

Thanksgiving Break

Mon Dec 1

Serine and threonine phosphorylation:
Protein kinase C and MAP kinases

F. Lee

Wed Dec 3

Cell cycle

F. Luca

Fri Dec 5

Apoptosis
Discussion Groups: Signal Transducation

X. Yang

Mon Dec 8

Exam 3