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Mondays and Wednesdays, 1:30 - 3:00 p.m.
255 Anatomy-Chemistry Building
2008 Course starts September 3
Course Directors:
Greg Van Duyne, Ph.D., vanduyne@mail.med.upenn.edu
Josh Wand, Ph.D., wand@mail.med.upenn.edu
Required Texts (in stock at Penn Bookstore):
van Holde, Johnson, & Ho, “Principles of Physical Biochemistry”, 2nd Edition, Prentice Hall.
Branden & Tooze, “Introduction to Protein Structure”, 2nd Edition, Garland
Sample outline
|
Date |
Topics |
Lecturer |
|
1 |
Introduction/Molecular interactions |
Van Duyne/Sharp |
|
2 |
Molecular interactions |
Sharp |
|
3 |
Molecular interactions |
Sharp |
|
4 |
Ligand Binding |
Sharp |
|
5 |
Denaturation, Folding |
Sharp |
|
6 |
Calorimetry |
Wand |
|
7 |
Sedimentation |
Englander |
|
8 |
NMR Spectroscopy |
Wand |
|
9 |
NMR Spectroscopy |
Wand |
|
10 |
NMR Spectroscopy |
Wand |
|
11 |
EPR Spectroscopy |
Tommos |
|
12 |
Spectroscopic probes |
Vanderkooi |
|
13 |
Spectroscopic probes |
Vanderkooi |
|
|
Mid-term Examination |
|
|
14 |
Optical imaging |
Vinogradov |
|
15 |
Magnetic Resonance Imaging |
Borthakur |
|
16 |
X-ray Diffraction |
Van Duyne |
|
17 |
X-ray Diffraction |
Van Duyne |
|
18 |
Molecular analysis – modeling |
Dunbrak |
|
19 |
Protein Structure |
Van Duyne |
|
20 |
Protein Structure |
Van Duyne |
|
21 |
Nucleic Acids Structure |
Van Duyne |
|
|
NO CLASS |
|
|
22 |
High order structure, electron microscopy |
Weisel |
|
23 |
Scattering methods |
Dominguez |
|
24 |
Protein chemistry |
DeGrado |
|
25 |
Protein design & engineering |
DeGrado |
|
25 |
Protein design & engineering |
DeGrado |
|
Final Examination |
