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Fall, every year
204 Stellar-Chance Labs
W, 3 - 5 p.m.
Instructors: Argon and Ischiropoulos
Prerequistes: BIOM 600 or equivalent
Protein misfolding and aggregation has been associated with a number of human diseases, ranging from Alzhemier's and Parkinson's disease to Respiratory Distress Syndrome, alpha(1)-antitrypsin deficiency and "mad cow" disease. This course will include lectures, directed readings and student presentations to cover seminal and current papers on the cell biology of conformational diseases including topics such as aggresome formation, protein degradation pathways (proteosome vs ER-associated degradation), effects of protein aggregation on cell function and mutations which lead to autosomal dominant diseases.
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Sample Schedule |
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1 |
Introduction: Course structure and administration |
Argon |
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2 |
Protein folding in the cell |
Argon |
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3 |
Protein folding in the cell |
Argon |
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4 |
Prion diseases |
Kal |
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5 |
Proteomic methods |
Speicher |
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6 |
Protein aggregation in neurodegenerative diseases |
Giasson |
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7 |
Protein aggregation in cells / Systemic amyloidosis |
Argon |
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8 |
Misfolding of cell surface receptors |
Rubenstein |
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9 |
Pulmonary surfactant proteins and diseases |
Beers |
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10 - end |
Students' Presentations |
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No textbook will be used. Each instructor will assign 1-2 papers that will be discussed in class.
Each students will pick a topic, e.g. a disease, to cover, assign papers to the class and will be expected to lead a discussion.
Grades will be based on the quality of the student's participation throughout the course.
