MEMBRANE STRUCTURAL BIOLOGY
(BMB 614)

Fall, every year (second semister half course; 1/2 credit)
Tuesdays and Thursdays 2:30 - 4:00 p.m.
1001 Stellar-Chance Labs

2008 course starts September 9

Director: Mark Lemmon

Prerequisites: Interest

Description: The composition, structure, and physical properties of cell membranes will be considered, as will recent advances in structural studies of membrane proteins. Topics will range from membrane structure to membrane protein folding, combining biophysical and cellular perspectives.

Number of Lectures: 13
Length of Lectures: 1.5 hours

Sample schedule

Lecture

Topic

Lecturer

1

The components and assembly of cell membranes I

Lemmon.

2

The components and assembly of cell membranes II

Lemmon

3

Assembly and folding of integral membrane proteins: structural and thermodynamic aspects

Lemmon

4

Biogenesis of polytopic membrane proteins (and its quality control)

Lemmon

5

The different membranes of the eukaryotic cell: trafficking and sorting

Burd

6

The structures of membrane proteins

Ferguson

.

Thanksgiving

.

7

Introduction to ion-channels

Deutsch

8

Assembly of multimeric ion-channel proteins

Deutsch

9

Viral-induced membrane fusion

Doms

10

Protein-lipid interactions

Axelsen

11

Cytoskeleton/membrane interactions and membrane remodeling

Janmey

12

.

Baumgart

13

Links to the extracellular matrix

Myers

14

Dynamics, diversity, domains, and asymmetry in biological membranes

Lemmon