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Protein Folding (BMB 619)1/2 credit, first half of semester Description: Readings and discussion of important literature on the protein folding problem Course materials: Handouts Course requirement: Each student will be involved in two literature presentations How students are evaluated: Participation and the quality of class presentations; written critical analysis of some of the literature discussed |
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Lecture |
Topic |
Lecturer |
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1 |
Introduction to equilibrium and kinetic principles, and methods |
Englander |
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2 |
The ‘old’ and ‘new’ view |
Englander |
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3 |
Methods – literature examples |
Englander |
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4 |
Structure of kinetic folding intermediates – by pulse labeling |
Englander |
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5 |
Structure of folding intermediates – equilibrium studies |
Englander |
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6 |
Structure of folding intermediates – by theoretical simulations |
Englander |
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7 |
The kinetic determinants – misfolding barriers |
Englander |
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8 |
The kinetic determinants – the initial nucleation barrier |
Englander |
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9 |
Kinetic transition state – phi analysis |
Englander |
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10 |
Kinetic transition state – psi analysis |
Englander |
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11 |
Protein folding in and on membranes - theoretical studies |
Axelsen |
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12 |
Protein folding in and on membranes - experimental studies |
Axelsen |
