BMB 700

Frontiers in Bioorganic and Medicinal Chemistry CHEM 700 / Pharm 630 / BMB 700

Fall

Course Directors: Cooperman and DeGrado
Mon/Wed/Fri, 11:00 a.m.
514 Chemistry Building

The course explores how recent developments in our abilities to make and analyze biologically important macromolecules provide new approaches to drug development and discovery.

Prerequisites: Open to all graduate students in the Chemistry, Biochemistry/Molecular Biophysics and Pharmacology departments and/or graduate groups. Other students should consult with Dr. Cooperman before enrolling. In general, a strong background in undergraduate chemistry is required, and at least one semester of biological chemistry is very desirable.

2 hourly exams – 100 pts each 1 final 150 pts

Sample Schedule from 2007

Lecture	Topic	Lecturer
9/5	Peptide structure, amino acids and conformational properties	DeGrado
9/7	Peptide structure, turns and bioactive peptides	DeGrado
9/10	Peptide structure, statistical mechanics of helix formation	DeGrado
9/12	Forces stabilizing protein structure and molecular recognition	DeGrado
9/14	Beta-proteins	DeGrado
9/17	Helical proteins	DeGrado
9/19	Membrane proteins	DeGrado
9/21	Foldamers	DeGrado
9/24	Synthesis of polypeptides	DeGrado
9/26	Sequencing of polypeptides/Biosynthesis of polypeptides	Cooperman
9/28	Biosynthesis of polypeptides	Cooperman
10/01	Exam 1
10/03	DNA structure	Cooperman
10/05	Nucleotide modification and consequences	Cooperman
10/08	Biosynthesis and chemical synthesis of nucleic acids	Cooperman
10/10	Protein:DNA interaction	van Duyne
10/12	Protein:DNA interaction	van Duyne
10/17	Mass spectrometry and small molecules	Blair
10/19	Mass spectrometry and small molecules	Blair
10/22	Mass spectrometry and Proteomics	Blair
10/24	Mass spectrometry and DNA Adducts	Blair
10/26	Oxidative DNA Damage	Blair
10/29	Exam 2
10/31	Mass spectrometry and Lipids	Blair
11/02	Introduction to Drug Metabolism	Blair
11/05	Characterization of Drug Metabolism	Blair
11/07	RNA structure and sequencing	Cooperman
11/09	RNA motifs/ribozymes	Cooperman
11/12	Aptamers	Cooperman
11/14	Modifications to proteins by endogenous reactive intermediates	Blair
11/16	Modifications to proteins by exogenous reactive intermediates	Blair
11/19	Introduction to Metabolomics	Blair
11/21	Mechanism of Translation	Cooperman
11/26	Expansion of the Genetic Code	Cooperman
11/28	mRNA and ribosome display	Cooperman
11/30	Biomimetics	Vinogradov
12/03	Biomimetics	Vinogradov
12/05	Oligosaccharide structure and function	Cooperman
12/07	Oligosaccharide synthesis	Cooperman

2007 syllabus in pdf format