Who are the students in the BMB Graduate Group?

Students in the Biochemistry and Molecular Biophysics Graduate Group are a very talented and diverse group, and come from all over the world. Their varied experience creates an exciting and interdisciplinary research environment where anything is possible. Below is an overview of the background of the current students.

 

Steve Artim (VMD/PhD - will matriculate 2008)
B.S., Haverford College, 2004 (Biology/Biochemistry)

Lab Rotation 1: Identifying novel PH domain-protein interactions (Dr. Mark Lemmon)
Lab Rotation 2: The effect of PANDER on glucagons in signaling in hepatocyte (Dr. Bryan Wolf)

Edward Ballister (matriculated 2007)
B.S., Berkeley, 2006 (Chemical Biololgy)

Lab Rotation 1: Chromatin dynamics of sporulation (Dr. Shelley Berger)
Lab Rotation 2: Engineering a protein nanotube building block (Dr. Bill DeGrado)

Emily Bassett (matriculated 2006)
B.S., University of Notre Dame, 2005 (Biochemistry)
Characterization of centromere chromatin assembly (Dr. Ben Black)

Nicholas Bessman (matriculated 2007)
B.S., Iowa State University, 2006 (Biochemistry)

Lab Rotation 1: Design, synthesis, and characterization of a Di-copper-binding bundle (Dr. Bill DeGrado)
Lab Rotation 2:
Structural insights into a novel Golgi-organizing protein ( Dr. Kate Ferguson)

Scott Bresler (MD/PhD - will matriculate in 2008)
B.A., Miami University, Oxford, 2006 (Chemistry/Philosophy)

Renee Carrington (matriculated Fall 2005)
B.S., Pace University, 2005 (Biochemistry)
The characterization of the YG box of the SMN protein" (Dr. Greg VanDuyne)

Sarah Chobot (matriculated Fall 2005)
B.A., Boston University, 2005 (Chemistry)
Differentiation of quinone thermodynamic states in Complex III (Dr. Les Dutton)

Sung Hee Choi (matriculated Fall 2003)
B.S., Korea University, 1999 (Genetic Engineering)
M.S., Korea University, 2001 (Bioengineering)
Understanding the mechanistic effects of somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (Dr. Mark Lemmon)

Robert Daber (matriculated 2004)
B.S. University of Maryland, Baltimore, 2004 (Biochemistry)
Functional engineering of novel genetic switches (Dr. Mitchell Lewis)

Tammer Farid (matriculated 2004)
B.A., DePauw University, 2002 (Chemistry)
Light-activated electron transfer maquettes (Dr. Les Dutton)

Helena Gaweska (matriculated 2003 – summer)
B.S., St. Joseph’s University, 2003 (Chemical Biology)
Characterization of TagA, a glycosyltransferase involved in teichoic acid biosynthesis in Gram-positive bacteria (Dr. Dewey McCafferty)

Carlos Gay-Antaki (matriculated 2004)
B.S. University of California, Santa Barbara, 2004 (Cell and Developmental Biology)
Axonal transport of lysosomal enzymes and engineered lysosomal enzymes in the mouse CNS (Dr. John Wolfe)

Bryan Gibb (matriculated 2003 – summer)
B.S., Pennsylvania State University, 2003 (Biochemistry and Molecular Biology)
Structural and biochemical studies of the tyrosine recombinases Cre and XerC/D (Dr. Greg Van Duyne)

Julie Glasscock (matriculated Fall 2005)
B.S., University of Minnesota, Duluth, 2005 (Biochemistry; Molecular Biology)
Spectroscopic studies of protein folding, dynamics and aggregation (Dr. Feng Gai)

John Gledhill (matriculated 2002)
B.S., Pennsylvania State University, 2002 (Biochemistry & Molecular Biology)
Application of confined space to determine protein substructure and NMR of large proteins (Dr. Josh Wand)

Jennifer Greene (matriculated Fall 2005)
B.S., University of Maryland, Baltimore, 2005 (Bioinformatics/Computational Biology)
Influence of solvent on the active site environment of peroxidases (Dr. Jane Vanderkooi)

Soren Harward (matriculated Fall 2005)
B.S., Brigham Young University, 2005 (Biochemistry)
Protease biochemistry in the coagulation and complement pathways (Dr. Scott Diamond)

Kathleen Hummel (matriculated 2006)
B.S., College of New Jersey, Trenton, 2006 (Physics)

Lab Rotation 1: Fluorescence of tyrosine (Dr. Jane Vanderkooi)
Lab Rotation 2: Hydrophobic anchors for protein encapsulation (Dr. Josh Wand)
Lab Rotation 3: Molecular modeling and proteins (Dr. Jeffery Saven)

Yu-San Huoh (matriculated 2006)
B.A., University of California, Berkeley, 2006 (Molecular Cell Biology)
Investigating the interaction between E3-Ubiquitin ligase Pellino and its substrates (Dr. Kate Ferguson)

Joseph Kielec (matriculated Fall 2003)
B.S., University of Pittsburgh, 1999 (Biological Sciences)
B.A., University of Pittsburgh, 1999 (Anthropology)
Nuclear magnetic resonance of large membrane proteins (Dr. Josh Wand)

Dan Kulp (matriculated 2004)
B.A. Rutgers, New Brunswick, 2004 (Biochemistry and Computer Science)
Discovering transmembrane protein association motifs using computational protein design and modeling (Dr. Bill DeGrado)

Joseph Laakso (matriculated Fall 2003)
B.S., State University of New York at Geneseo, 2003 (Biochemistry)
Single molecule studies of myosin-1 (Dr. Mike Ostap)

Bruce Lichtenstein (matriculated 2003)
B.A., Swarthmore College, 2002 (Biochemistry)
Study of synthetic covalently-linked two-electron cofactors in de novo designed proteins (Dr. Les Dutton)

Chun-Chi (David) Lin (matriculated 2003 – summer)
B.S., Creighton University, 2003 (Chemistry)
Structural and biochemical basis of protein-protein interaction events in Toll-like receptor signaling (Dr. Kate Ferguson)

Melissa Martinez-Rivera (matriculated 2007)
B.S., University of Puerto Rico, 2007 (Chemistry)

Lab Rotation 1: FT-SPR study of membrane-peptide interaction properties (Dr. Feng Gai)
Lab Rotation 2: Towards the electrochemical characterization of de novo designed proteins that serve as radical maquettes (Dr. Cecilia Tommos)

Eric Mellon (matriculated Fall 2005)
B.A., University of Delaware, 2002 (Biological Sciences)
Assessment of cerebral metabolism and pathology by
17O and 23Na magnetic resonance imaging (Dr. Ravi Reddy)

Leslie Milk (matriculated Summer 2005)
B.S., Bates College, 2005 (Physics)
Biophysical properties of glycoproteins (Walter Englander)

Kathleen Molnar, (matriculated 2007)
B.S., Princeton University, 2004 (Chemical Engineering)

Lab Rotation 1: Investigating Sup35 prion structure (Dr. Jim Shorter)
Lab Rotation 2: Hydrogen exchange by mass spec of Sup35 amyloid formation (Dr. Walter Englander)

Geronda Montalvo (matriculated 2006)
B.S., Clark Atlanta University, 2006 (Chemistry)
Biophysical characterization of β-peptide structures (Dr. Bill DeGrado)

David Moore (matriculated 2004)
B.A. 2000 University of Virginia (Interdisciplinary Sciences)
M.S. 2001 University of Virginia (Chemistry)
The role of transmembrane domains in signal transduction (Dr. Bill DeGrado)

Vonni Moorman (matriculated 2006)
B.A., Coe College, 2006 (Molecular Biology)

Lab Rotation 1: Limited proteolysis of alpha-synuclein fibrils (Dr. Walter Englander)
Lab Rotation 2: Crystallization of the Snf1 kinase tertiary protein complex (Dr. Ronen Marmorstein)
Lab Rotation 3: Towards a solution NMR structure of 2MP-a3C (Dr. Cecilia Tommos)
Lab Rotation 4: Methyl dynamics and entropy of Cdc42Hs probed by NMR (Dr. Josh Wand)

Katarina Moravcevic, (matriculated 2004)
B.S. Temple University, 2004 (Biochemistry)
Characterization of novel phosphoinositide effector domains (Dr. Mark Lemmon)

Nisha Ninan (matriculated Summer 2005)
B.A., University of Pennsylvania, 2001 (Biochemistry)
Biochemical and structural studies of the tudor domain of SMN (Dr. Greg Van Duyne)

David Pilkinton (MD/PhD; matriculated 2007)
B.A./B.S., University of Florida, 2004 (Philosophy)
B.S., University of Florida, 2004 (Physics)
Sodium magnetic resonance imaging of neuronal injury (Dr. Ravi Reddy)

Jesse Platt (MD/PhD - will matriculate 2009)
B.A., Princeton, 2007 (Chemistry)

Alexei Polishchuk (matriculated Fall 2005)
B.A., Princeton University, 2003 (Chemistry)
Structure-function relationships of the influenza A/M2 protein (Dr. Bill DeGrado)

Usha Ramachandran (maticulated 2007)
B.A., Rutgers University, 2006 (Molecular Biology/Biochemistry)

Lab Rotation 1: Clathrin mediated endocytosis: analysis/study of binding properties of C2alpha-L with clathrin (Dr. Kate Ferguson)
Lab Rotation 2: Study of voltage-sensor mutants in Shaker Kv channel (Dr. Zhe Lu)

Kevan Salimian (MD/PhD - will matriculate 2009)
B.S., U. of Maryland, College Park, 2007 (Biochemistry/Cell & Molecular Biology)

Katie Lorenz Sarachan (matriculated 2004)
B.S. Cornell University, 2004 (Biological Sciences)
Structural and biochemical studies of the SMN-Gemin2 protein complex (Dr. Mark Lemmon)

Karl Schmitz (matriculated Fall 2003)
B.S., Rensselaer Polytechnic Institute, 2002 (Biochemistry and Biophysics)
Structural and biochemical characterization of the NALP proteins and their role in inflammasome assembly (Dr. Kate Ferguson)

Chaim Schramm (matriculated 2006)
B.S., University of Michigan, 2006 (Biophysics)
Visualizing and investigating the mechanical properties and responses of cells (Dr. John Crocker)

Trey (Harry) Schroeder (matriculated 2006)
B.S., Washington and Lee University, 2004 (Chemistry)
Investigating consequences of competition between motors on cytoskeletal tracks (Dr. Yale Goldman)

J. Nathan Scott (matriculated Summer 2004)
B.S., Louisiana Tech University, 2003 (Physics)
Structure of biological water at extremes of temperature and pressure, and the influence of biological crowding on biomolecular solvation (Dr. Jane Vanderkooi)

Scott Shandler (matriculated 2002)
B.A. Brandeis University, 1998 (Computer Science)
Computational design of novel biologically active molecules (Dr. Bill DeGrado)

Fumin Shi (matriculated 2006)
B.S., Fudan University, 2006 (Biological Sciences)
Biochemical characterization of ErbB signaling properties (Dr. Mark Lemmon)

Carol Shultz (matriculated 2003 – summer)
B.S., Pennsylvania State University, 2003 (Biology)
Fjord-region PAH as a probe for the AKR pathway of PAH activation (Dr. Trevor Penning)

John Skinner (matriculated Summer 2004)
B.S., University of Pittsburgh, 2004 (Biology)
Characterizing partially unfolded protein structures and advancing the understanding of the conditions necessary for hydrogen exchange (Dr. Walter Englander)

Christopher Skipwith (matriculated 2007)
B.S., Morehouse College, 2006 (Chemistry)

Lab Rotation 1: The effect of Pellino2 constructs and mutations on innate immune signaling (Dr. Kate Ferguson)
Lab Rotation 2: Insights regarding the ultimate tensile strength of fibrin clots (Dr. John Weisel)

David Slochower (matriculated 2007)
B.A., Kenyon College, 2007 (Physics)

Lab Rotation 1: Functional studies with diffuse optics (Dr. Arjun Yodh)
Lab Rotation 2: Pump probe molecular dynamics of proteins (Dr. Kim Sharp)

Kate Smith (matriculated 2007)
B.A., Mt. Holyoke College, 2007 (Biochemistry)

Lab Rotation 1: Purification and biophysical characterization of Myo1c (Dr. Mike Ostap)
Lab Rotation 2:
Unusual dynamics of CD4M3: An unfolded designed peptide (Dr. Feng Gai)

Lee Solomon (matriculated 2006)
M.S., B.A., State University of New York, Buffalo, 2006 (Biological Sciences)
Modulation of oxygen chemistry and heme binding in synthetic proteins (Dr. Les Dutton)

Elizabeth Sweeny (matriculated 2007)
B.S., Loyola University, 2007 (Biochemistry)

Lab Rotation 1: Design and construction of a stable ferrous heme O2 in AP maquette (Dr. Les Dutton)
Lab Rotation 2: Protein remodeling by Hsp104 (Dr. James Shorter)

Benjamin Walters (matriculated 2007)
B.S., North Carolina State University, Raleigh, 2006 (Biochemistry/Genetics)

Lab Rotation 1: Conformational changes in invertebrate EGF receptors (Dr. Mark Lemmon)
Lab Rotation 2: Exploring slow folding kinetics of MBP (Dr. Walter Englander)

Camella Wilson (matriculated 2004)
B.S. Temple University, 2004 (Biochemistry)
Effect of PANcreatic DERived factor (PANDER) on the regulation of glucose homeostasis by the liver (Dr. Bryan Wolf)

Walter Witschey (matriculated 2004)
B.S. University of Virginia, 2004 (Physics)
Molecular imaging of musculoskeletal disease, Alzheimer's disease, functional imaging and multiple sclerosis using T1rho, sodium and magic echo imaging (Dr. Ravi Reddy)