Biochemistry and Molecular Biophysics Graduate Group

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Faculty

A strength of the BMB program is its broad combination of faculty interests and disciplines. Faculty members are drawn from many departments in the Perelman School of Medicine, from other schools in the University, and from affiliated local research institutes. Although of many different affiliations, the faculty are unified by the pursuit of research and training activities that align with the mission of BMB.

For a more extensive summary of faculty research interests, and links to lab web sites, click on topics under "Faculty by Research Interest"

Faculty alphabetically:                          
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

 

Faculty by Research Interest:

Control of gene expression and cellular programming
Cell signaling and intracellular trafficking
Chemical and structural biology
Bioenergetics, metabolism, and membranes
Biomedical imaging and supramolecular assemblies

Faculty by Department (Primary Appointment):

PENN MEDICINE
Biochemistry and Biophysics
Cancer Biology
Cell and Developmental Biology
Genetics
Medicine
Microbiology
Pathology and Laboratory Medicine
Pediatrics
Pharmacology
Physiology
Radiation Oncology
Radiology

SCHOOL OF ARTS AND SCIENCES
Chemistry
Biology
Physics and Astronomy

 

PENN ENGINEERING
Bioengineering
Chemical and Biomolecular Engineering

School of Dental Medicine

School of Veterinary Medicine

Wistar Institute

Fox Chase Cancer Center

Charles S. Abrams, M.D. Phospholipid signaling in platelets and lymphocytes

Yair Argon, Ph.D., Quality control of protein folding in the cell by molecular chaperones

Paul H. Axelsen, M.D., Biophysical studies of molecular recognition and rational drug design

Tobias Baumgart, Ph.D., Biomembrane function: thermodynamics, dynamics and mechanics

Joseph A. Baur, Ph.D. Molecular mechanisms of aging and caloric restriction

Joel S. Bennett, M.D., Regulation of integrin function

Shelley L. Berger, Ph.D., Role of adaptors in regulation of transcriptional activation in yeast and humans

Morris J. Birnbaum, M.D., Ph.D., Regulation of cellular and organismal metabolism, insulin action

Ben E. Black, Ph.D., Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange

Kathleen Boesze-Battagalia, Ph.D., Tetraspanin protein structure and role in degenerative disease processes

Lawrence Brass, M.D., Ph.D., Molecular basis for intracellular signaling in vascular biology

Theresa Busch, Ph.D., Photodynamic therapy, tumor microenvironment

Maya Capelson, Ph.D., Nuclear organization of chromatin and its role in gene regulation and cell differentiation

David Chenoweth, Ph.D., Development and application of synthetic methods for creating molecules that mimic or interact with biomolecules.

Sara Cherry, Ph.D., Genetic and mechanistic studies of viral-host interactions

Lewis A. Chodosh, M.D., Ph.D. Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging

Fevzi Daldal, Ph.D., Genetics, structure-function, regulation and biogenesis of cytochromes

Scott L. Diamond, Ph.D., Mechanobiology, gene transfer, blood systems biology, drug discovery, protease chemical-biology.

Bohdana Discher Ph.D., Designing and interfacing proteins with membranes and electronic devices

Roberto Dominguez, Ph.D., Actin cytoskeleton, structural biology

Gideon Dreyfuss, Ph.D., Nuclear transport, hnRNP complexes, RNA-binding proteins, spinal muscular atrophy

Roland L. Dunbrack, Jr. Ph.D., Methods and applications of protein structure prediction

P. Leslie Dutton, Ph.D., Oxidoreductase engineering; design and chemical synthesis of redox proteins

S. Walter Englander, Ph.D., Protein folding; structure, structure change, and dynamics; H-exchange; NMR

Hua-Ying Fan, Ph.D. Regulation of chromatin structure and its impact on human diseases

Kathryn M. Ferguson, Ph.D., Graduate Group Chair, Structural biology, growth factor receptor signaling, molecular mechanisms of protein-protein interactions

Feng Gai, Ph.D., Spectroscopic study of protein folding/misfolding

Benjamin A. Garcia, Ph.D., Quantitative proteomics for understanding signaling pathways.

Jerry Glickson, Ph.D., Molecular imaging: NMR spectroscopy and imaging of cancer; optical imaging of cancer; nanotechnology

Yale E. Goldman, M.D., Ph.D., Motor proteins studied by photochemistry and spectroscopy

Mark Goulian, Ph.D., Two-component signaling, bacterial regulatory circuits

Ekaterina L. Grishchuk, Ph.D. Mechanisms that drive and control chromosome motions in mitosis

Harry Ischiropoulos, Ph.D., Biological chemistry of nitric oxide; oxidative processes, protein aggregation and neurodegeneration

Paul A. Janmey, Ph.D., Cytoskeleton, biopolymer mechanics, phosphoinositides

F. Bradley Johnson, M.D., Ph.D., Telomeres, chromatin, DNA repair and their interface with cell senescence and aging.

Roland G. Kallen, M.D., Ph.D., Structure, function, and regulation of expression of ion channel

Rahul M. Kohli, M.D., Ph.D. Investigating the enzymatic basis for diversity generation in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution

Michael Lampson, Ph.D., Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinases

Matthew J. Lazzara, Ph.D., ErbB-mediated cell signaling

Mitchell Lazar, M.D., Ph.D., Nuclear receptors and the transcriptional regulation of metabolism

Virginia M.-Y. Lee, Ph.D., Pathobiology of Alzheimer's and Parkinson's disease

Mark A. Lemmon, Ph.D., Biochemistry/biophysics of intermolecular interactions of growth factor receptor signaling

Mitchell Lewis, D.Phil., Gene regulation; protein crystallography; structural basis of recognition

Paul A. Liebman, M.D., G-protein-receptor-arrestin mechanisms; visual signal transduction

Zhe Lu, M.D., Ph.D., Structure-function relationship of ion channels; molecular mechanisms of protein-protein interactions

Kristen W. Lynch, Ph.D., Mechanism and consequences of regulated alternative splicing

Michael S. Marks, Ph.D., Molecular mechanisms of intracellular protein transport and organelle biogenesis

Ronen Marmorstein, Ph.D., X-ray crystallography, chromatin regulation, tumor suppressors, oncoproteins, kinases, aging, structure-based inhibitor design

John I. Murray, Ph.D., Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy

Hillary C.M. Nelson, Ph.D., Structural biology; transcription; protein-DNA interactions; heat shock response

E. Michael Ostap, Ph.D., Biochemistry of contractile proteins, biophysics of cell motility, and characterization of unconventional myosins

Trevor M. Penning, Ph.D., Structure-function of aldo-keto reductases; role in steroid hormone action and chemical carcinogenesis

E. James Petersson, Ph.D., Semi-synthesis of labeled proteins to probe and control conformation

Benjamin L. Prosser, Ph.D., Mechano-signaling in the heart

Ravi Radhakrishnan, Ph.D., Computational structural biology and systems biology; cell membrane mediated trafficking; targeted drug delivery; cancer signaling

Arjun Raj, Ph.D., Systems biology; developmental biology; non-coding RNA

Ravinder Reddy, Ph.D., Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques

Heinrich Roder, Ph.D., NMR; protein folding mechanism; protein structure, dynamics and function

Harvey Rubin, M.D., Ph.D., Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation and enzymology and cell biology of serine proteases and serine protease inhibitors

Brian M. Salzberg, Ph.D., Multiple-site optical recording; excitation-secretion coupling; neural networks

Jeffery G. Saven, Ph.D., Theory, simulation and design of proteins and folding molecules

Kim A. Sharp, Ph.D., Interim Graduate Group Chair, Theory of protein and nucleic acid structure and function

James Shorter, Ph.D., Regulation of beneficial or neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones, and small molecules

Emmanuel Skordalakes, Ph.D., X-ray crystallography; telomere biology; cancer and aging

David Speicher, Ph.D., Cancer proteomics; structure-function of membrane associated proteins: protein chemistry and mass spectrometry

Alison Sweeney, Ph.D.,

Cecilia Tommos, Ph.D., Protein radicals and electrochemistry; cation-x interactions; protein forced folding

Phong Tran, Ph.D., Cytoskeleton organization and cellular pattern formation

Andrew Tsourkas, Ph.D. Molecular imaging, drug delivery, nanotechnology, and biotherapeutics

Gregory D. Van Duyne, Ph.D., Structural biology; protein-protein interactions; x-ray crystallography

Sergei A. Vinogradov, Ph.D., Functional macromolecules, optical imaging probes, porphyrin chemistry, dendrimer chemistry, oxygen microscopy and tomography

A. Joshua Wand, Ph.D., Protein structure and dynamics; molecular recognition and signal transduction; NMR spectroscopy

Felix W. Wehrli, Ph.D., MRI of biomaterials microstructure, mathematical modeling, image processing

John W. Weisel, Ph.D., Structural studies of molecular/cellular mechanisms in blood clotting and fibrinolysis

Aalim Weljie, Ph.D., Circadian, sleep, environmental and cancer metabolism via metabolomics profiling

Kathryn E. Wellen, Ph.D., Cancer cell metabolism, nutrient sensing

David F. Wilson, Ph.D., Integration of metabolism; oxidative phosphorylation; neuroregulation

Jeremy E. Wilusz, Ph.D., Regulation of noncoding RNA biogenesis and function

John H. Wolfe, V.M.D., Ph.D., Glycoproteins; lysosomal enzymes; storage diseases; gene transfer into brain

Xiaolu Yang, Ph.D., Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.

Kenneth S. Zaret, Ph.D. Investigating transcription factor interactions with chromatin

Zhaolan (Joe) Zhou, Ph.D., Epigenetic control of genome function in brain development and disease

X. Long Zheng, M.D., Ph.D. ADAMTS13 metalloprotease and microvascular thrombosis