A strength of the BMB program is its broad combination of faculty interests and disciplines. Faculty members are drawn from many departments in the Perelman School of Medicine, from other schools in the University, and from affiliated local research institutes. Although of many different affiliations, the faculty are unified by the pursuit of research and training activities that align with the mission of BMB. For a brief summary of faculty research interests, and links to lab web sites, click on Faculty by Research Interest. Click on faculty member's name to reach their PennMedicine homepage.
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Faculty by Department (Primary Appointment): |
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PENN MEDICINE |
SCHOOL OF ARTS AND SCIENCES PENN ENGINEERING |
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Charles S. Abrams, M.D. Phospholipid signaling in platelets and lymphocytes
Yair Argon, Ph.D., Quality control of protein folding in the cell by molecular chaperones
Paul H. Axelsen, M.D., Biophysical studies of molecular recognition and rational drug design
Tobias Baumgart, Ph.D., Biomembrane function: thermodynamics, dynamics and mechanics
Joseph A. Baur, Ph.D. Molecular mechanisms of aging and caloric restriction
Joel S. Bennett, M.D., Regulation of integrin function
Shelley L. Berger, Ph.D., Role of adaptors in regulation of transcriptional activation in yeast and humans
Morris J. Birnbaum, M.D., Ph.D., Regulation of cellular and organismal metabolism, insulin action
Ben E. Black, Ph.D., Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange
Kathleen Boesze-Battagalia, Ph.D., Tetraspanin protein structure and role in degenerative disease processes
Lawrence Brass, M.D., Ph.D., Molecular basis for intracellular signaling in vascular biology
Theresa Busch, Ph.D., Photodynamic therapy, tumor microenvironment
Sara Cherry, Ph.D., Genetic and mechanistic studies of viral-host interactions
Lewis A. Chodosh, M.D., Ph.D. Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging
Fevzi Daldal, Ph.D., Genetics, structure-function, regulation and biogenesis of cytochromes
Scott L. Diamond, Ph.D., Mechanobiology, gene transfer, blood systems biology, drug discovery, protease chemical-boiology
J. Alan Diehl, Ph.D., Aspects of signal transduction, cell division and metabolism as they pertain to cancer biology.
Bohdana Discher Ph.D., Designing and interfacing proteins with membranes and electronic devices
Roberto Dominguez, Ph.D., Actin cytoskeleton, structural biology
Gideon Dreyfuss, Ph.D., Nuclear transport, hnRNP complexes, RNA-binding proteins, spinal muscular atrophy
Roland L. Dunbrack, Jr. Ph.D., Methods and applications of protein structure prediction
P. Leslie Dutton, Ph.D., Oxido-reductase engineering; design and chemical synthesis of redox proteins
S. Walter Englander, Ph.D., Protein folding; structure, structure change, and dynamics; H-exchange; NMR
Hua-Ying Fan, Ph.D. Regulation of chromatin structure and its impact on human diseases
Kathryn M. Ferguson, Ph.D., Graduate Group Chair, Structural biology, growth factor receptor signaling, molecular mechanisms of protein-protein interactions
Feng Gai, Ph.D., Spectroscopic study of protein folding/misfolding
Benjamin A. Garcia, Ph.D., Quantitative proteomics for understanding signaling pathways.
Jerry Glickson, Ph.D., Molecular imaging: NMR spectroscopy and imaging of cancer; optical imaging of cancer; nanotechnology
Yale E. Goldman, M.D., Ph.D., Motor proteins studied by photochemistry and spectroscopy
Mark Goulian, Ph.D., Two-component signaling, bacterial regulatory circuits
Doron Greenbaum, Ph.D., Protease function, chemical biology, proteomics, biochemistry, cell biology, malaria
Ekaterina L. Grishchuk, Ph.D. Mechanisms that drive and control chromosome motions in mitosis
Robin M. Hochstrasser, Ph.D., Photochemical and photobiological dynamics; nonlinear optical spectroscopy
Harry Ischiropoulos, Ph.D., Biological chemistry of nitric oxide; oxidative processes, protein aggregation and neurodegeneration
Paul A. Janmey, Ph.D., Cytoskeleton, biopolymer mechanics, phosphoinositides
Roland G. Kallen, M.D., Ph.D., Structure, function, and regulation of expression of ion channel
Rahul M. Kohli, M.D., Ph.D. Investigating the enzymatic basis for diversity generation in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution
Todd Lamitina, Ph.D., Cellular osmoregulation, stress-induced gene expression, C. elegans genetics
Michael Lampson, Ph.D., Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinases
Matthew J. Lazzara, Ph.D., ErbB-mediated cell signaling
Virginia M.-Y. Lee, Ph.D., Pathobiology of Alzheimer's and Parkinson's disease
Mark A. Lemmon, Ph.D., Biochemistry/biophysics of intermolecular interactions of growth factor receptor signaling
Mitchell Lewis, D.Phil., Gene regulation; protein crystallography; structural basis of recognition
Paul A. Liebman, M.D., G-protein-receptor-arrestin mechanisms; visual signal transduction
Zhe Lu, M.D., Ph.D., Structure-function relationship of ion channels; molecular mechanisms of protein-protein interactions
Kristen W. Lynch, Ph.D., Mechanism and consequences of regulated alternative splicing
Michael S. Marks, Ph.D., Molecular mechanisms of intracellular protein transport and organelle biogenesis
Ronen Marmorstein, Ph.D., X-ray crystallography, chromatin regulation, tumor suppressors, oncoproteins, kinases, aging, structure-based inhibitor design
John I. Murray, Ph.D., Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy
Hillary C.M. Nelson, Ph.D., Structural biology; transcription; protein-DNA interactions; heat shock response
E. Michael Ostap, Ph.D., Biochemistry of contractile proteins, biophysics of cell motility, and characterization of unconventional myosins
Trevor M. Penning, Ph.D., Structure-function of aldo-keto reductases; role in steroid hormone action and chemical carcinogenesis
Ravi Radhakrishnan, Ph.D., Computational structural biology and systems biology; cell membrane mediated trafficking; targeted drug delivery; cancer signaling
Arjun Raj, Ph.D., Systems biology; developmental biology; non-coding RNA
Ravinder Reddy, Ph.D., Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques
Heinrich Roder, Ph.D., NMR; protein folding mechanism; protein structure, dynamics and function
Harvey Rubin, M.D., Ph.D., Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation and enzymology and cell biology of serine proteases and serine protease inhibitors
Brian M. Salzberg, Ph.D., Multiple-site optical recording; excitation-secretion coupling; neural networks
Casim A. Sarkar, Ph.D., Protein engineering; synthetic biology; cell-fate decisions
Jeffery G. Saven, Ph.D., Theory, simulation and design of proteins and folding molecules
Kim A. Sharp, Ph.D., Theory of protein and nucleic acid structure and function
James Shorter, Ph.D., Regulation of beneficial or neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones, and small molecules
Emmanuel Skordalakes, Ph.D., X-ray crystallography; telomere biology; cancer and aging
David Speicher, Ph.D., Cancer proteomics; structure-function of membrane associated proteins: protein chemistry and mass spectrometry
Cecilia Tommos, Ph.D., Protein radicals and electrochemistry; cation-x interactions; protein forced folding
Phong Tran, Ph.D., Cytoskeleton organization and cellular pattern formation
Gregory D. Van Duyne, Ph.D., Structural biology; protein-protein interactions; x-ray crystallography
Sergei A. Vinogradov, Ph.D., Functional macromolecules, optical imaging probes, porphyrin chemistry, dendrimer chemistry, oxygen microscopy and tomography
A. Joshua Wand, Ph.D., Protein structure and dynamics; molecular recognition and signal transduction; NMR spectroscopy
Felix W. Wehrli, Ph.D., MRI of biomaterials microstructure, mathematical modeling, image processing
John W. Weisel, Ph.D., Structural studies of molecular/cellular mechanisms in blood clotting and fibrinolysis
Kathryn E. Wellen, Ph.D., Cancer cell metabolism, nutrient sensing
David F. Wilson, Ph.D., Integration of metabolism; oxidative phosphorylation; neuroregulation
John H. Wolfe, V.M.D., Ph.D., Glycoproteins; lysosomal enzymes; storage diseases; gene transfer into brain
Xiaolu Yang, Ph.D., Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.
X. Long Zheng, M.D., Ph.D., ADAMTS13 metalloprotease and microvascular thrombosis