Department of Psychiatry

Penn Behavioral Health

About our Research

On-Going Research (pre-publication work)

Perlis

Questions under investigation:

  • Can clinical gains with Zolpidem be sustained by partial reinforcement?
    PI: Perlis; Funded by NIH/NCCAM
  • Which Insomnia related correlate best accounts for insomnia severity: Attention Bias, Cortical Arousal, Dysfunctional Thinking, or Somatic Arousal?
    Co-PI: MP; Co-PI: Colin Espie; Funded by NIH/NIMH
  • Do the transitions between good sleep, acute insomnia, and chronic insomnia have predictable mediators/moderators?
    PI: Perlis; Funded by NH/NIA
  • Does CBT-I, with or without modafinil, in patients with insomnia co-morbid with OSA improve sleep continuity and lead to better adherence with CBT-I? Does improved sleep continuity lead to better adherence with Positive Airway Pressure Therapy for OSA?
    PI: Perlis; Funded by Teva Pharmaceutical Industries, LTD.
  • Does completed suicide occur with a peak frequency at night?
    PI: Perlis (Collaborators: Grandner, G. Brown, M. Basner, S. Chakravorty, D. Dinges, M. Thase, Chaudhary, and P. Gehrman. In submission with AFSP.
  • Do patients with Insomnia exhibit an attenuation of the normal mesograde amnesia of sleep? Does this also exist as a main effect or as an interaction with again?
    PI: Perlis; In submission with NIH/ NIA
  • Does insomnia affect reproductive capacity?
    Co-PI: Perlis; Co-PI: Jackie Kloss, PhD. In Submission with NIH/NICHD.
  • How does sleep disturbance develop across pre-, during, and postpartum pregnancy?
    Co-PI: Perlis; Co-PI: Jackie Kloss, PhD. In submission with NIH/NICHD.

Grandner 

  • Cardiometabolic Health and Relationships to Sleep (CHARTS)
  • Sleep and Healthy Activity, Diet, Environment, and Social Factors (SHADES)
  • Short Sleepers: Neurobehavioral, Metabolic, and Biopsychosocial Characteristics (Short Sleep Study)
  • Long Term Follow-Up and Short and Long Sleepers
  • Sleep and Health in the American Population

For more information on Dr. Grandner's study, visit: http://www.michaelgrandner.com/pages/research-projects.html

Gehrman

  • What aspects of neurobiology confer resilience to PTSD in military personnel?
    PI: Kling; Funded by DARPA/DoD
  • How do circadian rhythms contribute to the pathophysiology of PTSD?
    PI: Gehrman; Funded by DARPA/DoD
  • How does CBT-I delivered by telehealth compare to in-person delivery in terms of clinical outcomes and health care costs?
    PI: Kuna; Funded by VA
  • What aspects of metabolism are altered in insomnia?
    PI: Gehrman; Funded by Merck
  • Does chronic insomnia increase risk for dementia?
    PI: Gehrman; Funded by Penn Institute of Aging pilot grant
  • How are genetics related to insomnia?
    PI: Gehrman; Unfunded project.
  • Is imagery rehearsal an effective treatment for nightmares in Veterans with PTSD?
    PI: Ross; Funded by DoD
  •  Can a mobile device help with stress and anger management?
    PI: Gehrman; Funded by DoD

Chakravorty

  • A randomized controlled study evaluating the efficacy of CBT-I for early recovery from alcohol dependence, and the role of family history of first-degree alcohol dependence in moderating insomnia symptoms and treatment outcomes.
  • Does CBT-I, with or without modafinil, in patients with insomnia co-morbid with OSA improve sleep continuity and lead to better adherence with CBT-I? Does improved sleep continuity lead to better adherence with Positive Airway Pressure Therapy for OSA?
    PI: Perlis.

Pilot Studies

Perlis

  • An exploratory study assessing whether insomnia negatively influences reproductive capacity. 
  • A pilot study on auditory sensory acuity in patients with insomnia
  • A pilot study re: the attenuation of the normal mesograde amnesia of sleep in insomnia

Gehrman

  • GWAS studies looking to identify genotypes for various insomnia related phenotypes
  • A rollout study for group CBT-I in veterans using telehealth technologies
  • An exploratory study assessing for PTSD related biomarkers

Grandner 

  • An exploratory study assessing whether survey of lab based measures can discriminate between true short sleep and insufficient sleep syndrome

Findley

  • A clinical case-series study exploration of CBT-I outcomes and the effects of treatment on non-sleep measures

Chakravorty

  • A pilot study evaluating the efficacy of CBT-I for early recovery from alcohol dependence.

Gooneratne

  • A study assessing the effects of CPAP (vs. sham CPAP) on insomnia in the context of SDB.

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