Cell & Molecular Biology Graduate Group

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Cancer Genetics and Signal Transduction

The following G&E laboratories are interested in cancer genetics and signal transduction

Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel

Hematopoiesis, gene expression, transcription factors, chromatin

Russ Carstens Study of the molecular mechanisms of alternative splicing.
Brian Capell
Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Douglas Epstein
Regulation of Sonic hedgehog signaling in development and disease
Robert Faryabi

Develop analytical methods for precision cancer genomics.

Donna L. George
Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Jennifer Kalish Understanding and improvingdetection of epigenetics and mosaicismin human disease
Maureen Murphy p53 tumor suppressor, HSP70 chaperone, autophagy, programmed cell death. Keywords: Cancer Genetics and Signal Transduction, Genetics of diabetes and metabolism, Animal modeling of human disease
Doris Stoffers
Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Meera Sundaram Regulation and targets of Ras/ERK signaling in C. elegans
Kai Tan
Model gene regulatory networks in development and disease
Doris Wagner
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.

Other CAMB laboratories (with research related to G&E) interested in cancer genetics and signal transduction.

Craig Bassing Elucidation of molecular mechanisms which regulate the initiation and proper repair of DNA double strand breaks during chromosomal V(D)J recombination.
Garrett Brodeur Molecular biology and genetics of childhood cancer, especially neuroblastoma.
Lewis Chodosh Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
David Feldser

Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression

Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Warren Pear Processes that control normal development and malignant transformation.
Anil Rustgi Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Ben Stanger Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.

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