Cell & Molecular Biology Graduate Group

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Animal Modeling of Human Disease 

The following G&E laboratories are interested in animal modeling of human disease

Naiara Aquizu Lopez Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Nancy Bonini Molecular genetics of neurodegenerative disease.
Edward S. Brodkin Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Maja Bucan
Genetic dissection of complex behaviors in mice; functional genomics.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Nancy Cooke
The role of chromatin structure in eukaryotic gene regulation.
Gideon Dreyfuss RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Douglas Epstein
Regulation of Sonic hedgehog signaling in development and disease
David L. Gasser
Genes that affect the immune response
Donna L. George
Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Thomas Jongens
Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Klaus Kaestner

Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.

Yana Kamberov Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Brett Kauffman

The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.

Mitchell Lazar
* Regulation of gene expression and metabolism by nuclear hormone receptors
* Mechanism of obesity-associated insulin resistance and diabetes
Aimee Payne *Genetic and functional characterization of human autoantibody repertoires
*Targeted therapy for pemphigus
*Regulation of desmosome assembly and disassembly
Nina Luning Prak
Mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
J. Eric Russell Control and function of human embryonic globin genes.
Eileen M. Shore
Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers
Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katalin Susztak
Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB laboratories (with research related to G&E) interested in animal modeling of human disease.

Lewis Chodosh Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
Tom Curran The molecular basis of normal and neoplastic growth formation of the brain to uncover new approaches for the treatment of pediatric brain tumors.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Brad Johnson Molecular biology of aging, Werner syndrome, telomeres, recombination.
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Sarah Millar Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth.
Warren Pear Processes that control normal development and malignant transformation.
Anil Rustgi Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.

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