The following GGR laboratories are interested in animal modeling of human disease
The molecular basis of synaptic plasticity, learning and memory; the molecular basis of sleep/wake regulation. |
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| Edward S. Brodkin | Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia. |
| Maja Bucan |
Genetic dissection of complex behaviors in mice; functional genomics. |
| Nancy Cooke |
The role of chromatin structure in eukaryotic gene regulation. |
| Gideon Dreyfuss | RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery. |
| Douglas Epstein |
Regulation of Sonic hedgehog signaling in development and disease |
| Joshua R. Friedman |
Liver development, biliary disease |
| David L. Gasser |
Genes that affect the immune response |
| Donna L. George |
Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers. |
| Aaron D. Gitler | Genetic and cellular mechanisms of neurodegeneration. |
| Thomas Jongens |
Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification |
| Klaus Kaestner |
Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. |
| Brett Kauffman |
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission. |
| Mitchell Lazar |
* Regulation of gene expression and metabolism by nuclear hormone receptors * Mechanism of obesity-associated insulin resistance and diabetes |
| Nina Luning Prak |
mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition |
| Eileen M. Shore |
Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. |
| Doris Stoffers |
Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. |
| J. Eric Russell |
Control and function of human embryonic globin genes. |
| Zhaolan (Joe) Zhou | Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease |
Other CAMB laboratories (with research related to GGR) interested in animal modeling of human disease.
| Lewis Chodosh | Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging. |
| Tom Curran | The molecular basis of normal and neoplastic growth formation of the brain to uncover new approaches for the treatment of pediatric brain tumors. |
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models. |
| Brad Johnson | Molecular biology of aging, Werner syndrome, telomeres, recombination. |
| Brian Keith | How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression. |
| Sarah Millar | Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth. |
| Warren Pear | Processes that control normal development and malignant transformation. |
| Anil Rustgi | Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI). |
| Celeste Simon | Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. |
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