The following laboratories are interested in signal transduction.
||Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.|
||Signal transduction and cell cycle control.|
|Kendra Bence||Mouse models of obesity/diabetes, neuronal control of energy balance, protein tyrosine phosphatases, signal transduction.|
||The regulation of growth and metabolism.|
|Lawrence F. Brass
||Mechanisms of thrombosis.|
||Regulation and function of the T cell cytoskeleton.|
||Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.|
||Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.|
|J. Kevin Foskett
Ion channels, calcium signaling, cystic fibrosis.
|Paul Janmey||Cytoskeleton, phosphoinositide signalling, cell mechanics.|
|Mark Kahn||Signaling pathways in angiogenesis and hemostasis.|
|Michael Lampson||Mitotic kinase signaling, chromosome segregation in mitosis and meiosis, kinetochore function.|
||Signaling by growth factor receptor tyrosine kinases, and inositol phospholipid signaling - biochemical, cellular, and structural biological studies.|
||Signal transduction, proliferation, differentiation, apoptosis.|
||TGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis.|
|Bryan A. Wolf
Signaling mechanisms of insulin secretion; Cytokines and diabetes.
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