Yair Argon
|
Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation. |
Erfei Bi
|
Development of cell polarity and control of cytokinesis in budding yeast. |
Morris Birnbaum
|
The regulation of growth and metabolism. |
Christopher Burd
|
ARF GTPases, Rab GTPases, endocytosis, secretion, phosphatidylinositol kinase signaling. |
Margaret Chou
|
Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination. |
Andy Dancis
|
Iron transport into mitochondria, Heme sythesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia |
Carol Deutsch
|
Function and assembly of potassium channels in human T lymphocytes. |
Robert Doms
|
HIV; Emerging viral pathogens; Cell biology of Alzheimer's disease. |
J. Kevin Foskett
|
Ion channels, calcium signaling, cystic fibrosis. |
| Claudio Giraudo |
The research of the laboratory is mainly focused on understanding the membrane trafficking events and fusion machinery involved in cytotoxic immune response. Additionally, we also study the influence of membrane lipid composition on protein sorting. |
Yale Goldman
|
Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors. |
Wei Guo
|
The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis. |
Erika L. Holzbaur
|
Microtubule-based motility. |
Paul Janmey
|
Cytoskeleton, phosphoinositide signalling, cell mechanics. |
Anna S. Kashina
|
Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis. |
Mark Lemmon
|
Signaling by growth factor receptor tyrosine kinases, and inositol phospholipid signaling - biochemical, cellular, and structural biological studies. |
Joshua Lipschutz
|
The exocyst complex - as it relates to protein synthesis and trafficking, kidney development (especially cystogenesis and tubulogenesis), and kidney diseases of abnormal synthesis and polarity such as autosomal dominant polycystic kidney disease. |
Frank Luca
|
Yeast and mammalian cell cycle regulation; Cytokinesis.
Daughter cell-specific gene expression; Polarized growth
Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM). |
Michael S. Marks
|
Regulation and diseases of intracellular protein transport and organelle biogenesis. |
Jordan S. Orange
|
Directed secretion at the cytolytic immunological synapse; Role of NF-kB activation in cytolytic function |
Michael Ostap
|
Molecular mechanisms of cell motility. |
Mechthild Pohlschroder
|
Prokaryotic protein translocation across hydrophobic membranes. |
X. Long Zheng
|
Biosynthesis and Structure-Function of ADAMTS13 Metalloprotease. |
