Cell & Molecular Biology Graduate Group

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Intracellular Trafficking and Organelle Function

The following laboratories are interested in Intracellular Trafficking and Organelle Function.

Yair Argon
Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Erfei Bi
Development of cell polarity and control of cytokinesis in budding yeast.
Morris Birnbaum

The regulation of growth and metabolism.
Margaret Chou
Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Andy Dancis

Iron transport into mitochondria, Heme sythesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Carol Deutsch
Function and assembly of potassium channels in human T lymphocytes.
Robert Doms
HIV; Emerging viral pathogens; Cell biology of Alzheimer's disease.
J. Kevin Foskett

Ion channels, calcium signaling, cystic fibrosis.

Claudio Giraudo

The research of the laboratory is mainly focused on understanding the membrane trafficking events and fusion machinery involved in cytotoxic immune response. Additionally, we also study the influence of membrane lipid composition on protein sorting.

Yale Goldman
Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Wei Guo
The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur
Microtubule-based motility.
Paul Janmey

Cytoskeleton, phosphoinositide signalling, cell mechanics.
Anna S. Kashina

Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Mark Lemmon
Signaling by growth factor receptor tyrosine kinases, and inositol phospholipid signaling - biochemical, cellular, and structural biological studies.
Joshua Lipschutz
The exocyst complex - as it relates to protein synthesis and trafficking, kidney development (especially cystogenesis and tubulogenesis), and kidney diseases of abnormal synthesis and polarity such as autosomal dominant polycystic kidney disease.
Frank Luca
Yeast and mammalian cell cycle regulation; Cytokinesis.
Daughter cell-specific gene expression; Polarized growth
Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael S. Marks
Regulation and diseases of intracellular protein transport and organelle biogenesis.
Michael Ostap
Molecular mechanisms of cell motility.
Mechthild Pohlschroder
Prokaryotic protein translocation across hydrophobic membranes.
X. Long Zheng

Biosynthesis and Structure-Function of ADAMTS13 Metalloprotease.

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