Cell & Molecular Biology Graduate Group

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Epigenetics, gene regulatory networks & signal integration

The following DSRB labatories are interested in Epigenetics, gene regulatory networks & signal integration:

Marisa Bartolomei The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Avinash Bhandoola We're interested in the mechanisms by which some hematopoietic progenitor cells migrate to the thymus, as well as the transcriptional mechanisms in the thymus that direct the earliest thymus colonizing progenitors down the T cell lineage.
E. Bryan Crenshaw III Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Paul Gadue My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Daniel Kessler * Establishment and organization of the primary germ layers
* Formation and function of the Spemann organizer in axial development
* Signaling and transcriptional networks in the vertebrate gastrula
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner Our lab is broadly interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine
Sarah Millar Development of hair follicles, mammary glands, taste papillae and teeth; regeneration and neogenesis of hair follicles and teeth; hair follicle, mammary gland and dental stem cells; skin and mammary gland tumorigenesis; microRNA functions in embryonic and postnatal skin and mammary glands; functions of histone deacetylases in skin and hair follicle development and renewal.
Edward Morrisey lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Michael Parmacek Transcriptional programs that regulate cardiovascular development
Richard Schlultz Egg activation and gene expression in mouse embryos.
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Patrick Seale Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity. We are particularly interested in early determination and specification events; this involves the commitment of mesenchymal stem cells to a preadipose cell fate. We are also exploring pathways that determine the fate (and thus the function) of different types of fat cells.
Ling Qin Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
P. Jeremy Wang Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.