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Rexford
S. Ahima
Associate Professor of Medicine
Division of Endocrinology, Diabetes & Metabolism
Cell
Biology and Physiology Program
Address
712A Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104
Office tel.: 215 573-1872
Lab tel.: 215 573-1875
Fax: 215 573-5809
E-mail: ahima@mail.med.upenn.edu
Link(s)
Dr. Ahima's Lab
Webpage
Education
University of London: BSC (Anatomy/Endocrinology), 1981.
Tulane University School of Medicine: PhD (Neuroscience),
1992.
University of Ghana Medical School: MD (Medicine/Surgery),
1986.
Albert Einstein College of Medicine, Bronx, NY: Intern/Resident
(Internal Medicine), 1995.
Beth Israel Deaconess Medical Center, Harvard Medical School:
Research fellowship and subspeciality training (Endocrinology,
Diabetes and Metabolism), 1998.
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Research
Interests
- Neuroendocrine regulation of body weight
and glucose.
Key
words: Obesity, diabetes, energy homeostasis, brain,
neuroendocrinology
Description
of Research
Research in my lab focuses on the regulation of energy homeostasis. Contrary to the prevailing view of the adipocyte as merely a specialized cell for the storage of excess energy, there is increasing evidence that adipose tissue plays a more active role. Leptin and other adipocyte-secreted hormones signal to the brain and peripheral organs to control feeding, energy expenditure, neuroendocrine and immune function, and glucose and lipid metabolism. Adipose-derived cytokines and procoagulant and vasoactive factors have also been implicated in the pathogenesis of diabetes, cardiovascular disease and other obesity related diseases.
Projects
- Adipokine regulation of CNS and peripheral metabolism
- Role of lipid droplet proteins in lipid and glucose metabolism
- Metabolic actions of myokines
Selected
Publications
Imai Y, Varela GM, Jackson MB, Graham MJ, Crooke
RM, Ahima RS. Reduction of hepatosteatosis and lipid levels
by an adipose differentiation-related protein antisense oligonucleotide.
Gastroenterology 132(5):1947-54, 2007
Wong T, Hildebrandt MA, Thrasher SM, Appleton
JA, Ahima RS, Wu GD. Divergent metabolic adaptations to intestinal
parasitic nematode infection in mice susceptible or resistant
to obesity. Gastroenterology 133(6):1979-88, 2007
Singhal NS, Lazar MA, Ahima RS. Central resistin induces hepatic insulin resistance via neuropeptide Y. J Neurosci. 27(47):12924-32, 2007
Hoyda TD, Fry M, Ahima RS, Ferguson AV. Adiponectin
selectively inhibits oxytocin neurons of the paraventricular
nucleus of the hypothalamus. J Physiol. 585(Pt 3):805-16,
2007
Imai Y, Patel HR, Hawkins EJ, Doliba NM, Matschinsky
FM, Ahima RS. Insulin secretion is increased in pancreatic
islets of neuropeptide Y-deficient mice. Endocrinology
Dec;148(12):5716-23, 2007
Search PubMed for more articles
Lab
Rotation
Projects
- Adipokine regulation of CNS and peripheral metabolism
- Role of lipid droplet proteins in lipid and glucose metabolism
- Metabolic actions of myokines
- Lab personnel:
Gladys Varela- Cell and Molecular Biology Graduate Group
Rajesh Patel, PhD- Postdoctoral Fellow
Emilie Caron, PhD- Postdoctoral Fellow
Imo Akpan- MSIV, School of Medicine
Hyeong Kyu Park, MD- Visiting Scientist
Regan Roat- Senior, School of Arts & Sciences
Ravindra Dhir, PhD- Senior Research Laboratory Manager
Xiaoyan Yin, MD- Research Specialist
Yumi Imai, MD- Instructor of Medicine
last updated 7/2008
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